Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Progastrin is a pro-hormone that, in physiological conditions, is maturated in gastrin in G cells of the stomach. The role of the gastrin is to stimulate the secretion of gastric acids during digestion. It is also important for the regulation of cell growth of the gastric mucosal.
In a healthy person, progastrin is not detectable in the peripheral blood. However, progastrin is abnormally released in the blood of patients with different cancers (colorectal, gastric, ovarian, breast, cervix uterus, melanoma…) The gene GAST coding for progastrin is a direct target gene of the WNT/ß-catenin oncogenic pathway. The activation of this oncogenic pathway is an early event in cancer development.
Chronic activation of the WNT/ß-catenin oncogenic pathway occurs in almost all human solid tumors and is a central mechanism in cancer biology that induces cellular proliferation, blocking of differentiation leading to primary tumor growth and metastasis formation.
Progastrin measured in the peripheral blood of patients on treatments, could be a new powerful marker for diagnosis and prognosis at different stages.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cancer patients | Other | 420 patients affected by different types of cancer and treated in a curative or a palliative intent. In total 17 cohorts will be open, including: breast cancer, head and neck carcinomas, renal cell carcinoma, prostate carcinoma, lung carcinoma, hepatocellular carcinoma, colorectal carcinoma, thyroid cancer, pancreatic adenocarcinoma, ovarian adenocarcinoma, glioblastoma, endometrial adenocarcinoma, bladder carcinoma, oesophago-gastric carcinoma, B-cell lymphoma, gastric carcinomas. Patients enrolled in curative intent treatment cohorts will never have been previously treated for their cancer. Patients enrolled in non-curative intent treatment cohorts will have never been treated for their metastatic cancers previously, or have developed advanced/metastatic diseases as relapses of localized cancers previously treated with curative intent therapeutic strategies. Other cohort will be open (stability cohorts) : nychtemer cohort and post-operative kinetic cohort. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood draws | Other | Blood draws are realized at each steps of patient disease management. The volume of each blood drawn is 25 mL for progastrin measurements and 5 mL for the dosage of the other tumor markers. The frequency depend to the cancer and treatment administered :
|
| Measure | Description | Time Frame |
|---|---|---|
| ROC curve AUC regarding diagnostic accuracy of progastrin levels at baseline in cancer patients compared to non-cancer controls | Progastrin concentration in plasma samples will be measured with an ELISA Kit (CancerREAD LAB) provided by ECS Progastrin. | At baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Longitudinal kinetic of progastrin values during treatments, assessed by modeled kinetic parameters of interest | A nonlinear mixed effect model will be used to model the progastrin measurements done during treatments and follow-up of patients.The effect of each event (chemotherapy, surgery…) on the progastrin value and in the inter-individual variability of production and/or elimination rates of progastrin will be analyzed. Progastrin will be measured by ELISA, and the values will be expressed in pM. Measures will be done depending on the treatment received. Chemotherapy, every 3 or 4 weeks. Oral treatments: every 3 to 12 weeks. Surgery or radiotherapy: before and after the treatment. Follow up: concomitantly to the visits scheduled for the regular follow up of the patients. |
Not provided
Histologically and/or cytologically documented (documentation obtained before or after diagnostic surgical procedure when clinical suspicion is strong), cancers for the following cohorts:
o Breast carcinomas
o Gastric carcinomas
o Renal carcinomas
o Prostate carcinomas
o Lung carcinomas: NSCLC and SCLC
o Hepatocellular carcinomas
o Colorectal carcinomas
Patient older than 18 years.
Patients who gave its written informed consent to participate to the study
Patients affiliated to a social insurance regime
Specific inclusion criteria for curative treatment strategy cancer patients:
Specific inclusion criteria for non-curative treatment strategy cancer patients:
The following tumor type specific inclusion criteria must be met in addition to the inclusion criteria listed above:
Breast carcinomas
• All cohorts:
Invasive breast ductal carcinoma, or
Invasive breast lobular carcinoma
Planned to be treated with surgery, with/without neo-adjuvant and/or adjuvant chemotherapy and/or anti-hormone treatment
Gastric carcinomas
All cohorts:
o Intestinal-type adenocarcinoma, or
o Diffuse cell type adenocarcinoma
Curative intent treatment patient cohort:
Renal carcinomas • All cohorts:
Any histology of renal cancer is accepted (non-clear cell renal cancer could be included)
A pathology proof of renal cell carcinoma is not necessarily provided if patients present typical radiologic characteristics of renal cancer on imaging
• Curative intent treatment patients cohort:
Planned to be treated with partial or total nephrectomy
Prostate carcinomas
Curative intent treatment patients cohort:
o Localized prostate cancer with high risk features : StageT2b , T2c or T3 and/or Gleason >= 4+3 and/or PSA >= 20 and/or N+
o Planned to be treated with radical prostatectomy or radiotherapy (potentially associated with androgen deprivation therapy). Brachytherapy and/or focused ultrasounds are not allowed.
Non-curative intent treatment patients cohort:
Lung carcinomas treated by immunotherapy :
• Non-curative intent patients cohort:
o NSCLC stage IV according to 8th TNM classification planned to be treated with immunotherapy, with/ without chemotherapy
Lung carcinomas excluding those treated with immunotherapy:
Curative intent treatment patients cohort:
o NSCLC histology only
o Stage I-II according to 8th TNM classification
o Stage IIIA-B according to 8th TNM classification
o Planned to be treated with radical treatment (surgery or radiotherapy with/without concurrent chemotherapy), potentially associated with neo-adjuvant or adjuvant treatment
Non-curative intent patients cohort:
Hepatocellular carcinomas A pathology proof of HCC is not necessarily provided if patients present typical radiologic characteristics of hepatocellular carcinoma on imaging
Absence or chronic hepatic encephalopathy, absence of refractory ascites
Indication of a treatment strategy with curative intent, except liver transplantation: surgical resection, monopolar radiofrequency ablation for HCC (1 to 3 nodules ≤3 cm) or multibipolar radiofrequency if nodule ≤4 cm).
• Non-curative intent patients cohort:
Indication of a treatment strategy with no curative intent: transarterial intra-hepatic chemoembolization, targeted therapies (tyrosine kinase inhibitors or monoclonal antibodies) or immune therapy.
Colorectal carcinomas
• Curative intent treatment patients cohort:
o Lieberkühn adenocarcinoma associated with metastases planned to be treated with peri-operative chemotherapy +/- targeted agent and interval surgery
Head and neck carcinomas
All cohorts
o Head and neck squamous cell carcinoma from oral cavity, oropharynx, hypopharynx, larynx
Curative intent treatment patients cohort:
o Planned to be treated with a radical treatment (surgery and/or radiotherapy potentially associated with concurrent chemotherapy) with/without neo-adjuvant/adjuvant chemotherapy.
Non-curative intent treatment patients cohort:
o De novo metastatic or metastatic/loco-regional relapse planned to be treated with chemotherapy and/or immunotherapy
Thyroid cancer • Curative intent patient cohort o Thyroid carcinoma differentiated, poorly differentiated, papillary, vesicular, Hurthle Cell o For which a iodine treatment is indicated (Iodine treatment will be discussed after surgery. In the case the histological result does not confirm a high risk thyroid cancer, patient will be withdrawn from the study. In the same way, if a iodine treatment is not recommended after surgery, patient will be withdrawn from the study. In both cases, patient will be replaced).
Pancreatic carcinomas
• Curative intent patients cohort:
o Pancreas exocrine adenocarcinoma planned to be treated with initial surgery with/without neo-adjuvant chemotherapy and with/without adjuvant chemotherapy or radiotherapy
Ovarian adenocarcinomas • Non/uncertain curative intent patients cohort:
o 1st platinum-sensitive relapse
Glioblastoma • Curative intent patients cohort:
o Planned to be treated with surgical resection, followed by adjuvant temozolomide and radiotherapy
Endometrial adenocarcinomas
Non-curative intent patients cohort:
o Type 1 (endometrioid or mucinous) or type 2 endometrial (serous, clear cell, undifferentiated carcinoma and carcinosarcoma) cancers
o Planned to be treated with non-curative systemic treatment for metastatic or advanced disease
Bladder carcinoma
Superficial Oesophago-gastric cancer • Curative intent patients cohort:
o Superficial oesophago-gastric carcinomas (adenocarcinomas or epidermoid carcinomas) of Stage T1 planned to be treated by endoscopic surgery
Diffuse Large B-Cell Lymphoma (DLBCL)
• Curative intent patients cohort:
o Patients planned to be treated with R-CHOP (Rituximab-Cyclophosphamide, Hydroxyadriamycine, Oncovin, Prednisone)
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Benoit YOU, MD | Contact | 04 78 86 43 53 | +33 | benoit.you@hu-lyon.fr |
| Sara CALATTINI | Contact | 04 78 86 37 79 | +33 | sara.calattini@chu-lyon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Benoit YOU, MD | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de NEURO-ONCOLOGIE du Groupement Hospitalier EST | Recruiting | Bron | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40598473 | Derived | You B, Couraud S, Ceruse P, Badet L, Paparel P, Durand A, Guillet M, Merle P, Lescuyer G, Philip CA, Ducray F, Pioche M, Karlin L, Lifante JC, Glehen O, Bolze PA, Chauvenet M, Langlois-Jacques C, Subtil F, Piecyk M, Carrot A, Joubert D, Prieur A, Vire B, Calattini S, Payen L. Diagnostic value of the wnt target and cancer-associated blood biomarker hPG80: ONCOPRO case-control prospective study. Biomark Res. 2025 Jul 1;13(1):91. doi: 10.1186/s40364-025-00793-z. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| 6 years |
| Nycthemeral and weekly and post-operative progastrin variations | 24 patients will be selected, upon their agreement and serum high levels, to enter in nychtemer (12 patients) or weekly (12 patients) cohorts. For the Nychtemer cohort, progastrin will be assayed at d1 at 8:00 am; 11:00 am; 2:00 pm; 5:00 pm; 8:00 pm and at d2 at 8:00 For the weekly cohort, progastrin will be assayed Day 1; Day 8; Day 15 and +/- Day 22; ideally on the same hour times. Progastrin will be measured by ELISA, and the values will be expressed in pM. | every 3 hours within 24 hours for the Nycthemeral cohort, and every week for 2 or 3 weeks for the weekly cohort |
| Determinants of progastrin serum values: hepatic function | A nonlinear mixed effect model will be used to correlate individual values of progastrin (expressed in pM) with individual characteristic on the patient (hepatic function, as measured by the concentration of AST, ALT and bilirubin). Measures will be done Chemotherapy, every 3 or 4 weeks. Oral treatments: every 3 to 12 weeks. Surgery or radiotherapy: before and after the treatment. Follow up: concomitantly to the visits scheduled for the regular follow up of the patients | 6 years |
| Determinants of progastrin serum values: renal function | A nonlinear mixed effect model will be used to correlate individual values of progastrin (expressed in pM) with individual characteristic on the patient (renal function, as measured by creatinin concentration and creatinin clearance). Measures will be done Chemotherapy, every 3 or 4 weeks. Oral treatments: every 3 to 12 weeks. Surgery or radiotherapy: before and after the treatment. Follow up: concomitantly to the visits scheduled for the regular follow up of the patients | 6 years |
| Determinants of progastrin serum values: age | A nonlinear mixed effect model will be used to correlate the individual characteristics of the patient (age and gender) with progastrin concentration at the inclusion. | at the inclusion |
| Determinants of progastrin serum values: gender | A nonlinear mixed effect model will be used to correlate genders with progastrin concentrations at the inclusion. | at the inclusion |
| Overall survival | The relationships between the progastrin kinetics during and after treatment and overall survival will be analyzed. Analyses will be performed separately on patients with curative intent treatment and on patients with palliative intent treatment. Measures wil be done At the end of the study (6 years for patients enrolled in curative intent and 5 years for patients enrolled in non-curative intent) or alternatively at the occurrence of progression or relapse. | 6 years |
| recurrence free survival | The relationships between the progastrin kinetics during and after treatment and recurrence free survival will be analyzed. Analyses will be performed separately on patients with curative intent treatment and on patients with palliative intent treatment. Measures wil be done At the end of the study (6 years for patients enrolled in curative intent and 5 years for patients enrolled in non-curative intent) or alternatively at the occurrence of progression or relapse. | 6 years |
| progression free survival | The relationships between the progastrin kinetics during and after treatment and progression free survival will be analyzed. Analyses will be performed separately on patients with curative intent treatment and on patients with palliative intent treatment. Measures wil be done At the end of the study (6 years for patients enrolled in curative intent and 5 years for patients enrolled in non-curative intent) or alternatively at the occurrence of progression or relapse. | 6 years |
| The tumor size at cancer diagnosis | The size of the tumor will be correlated to progastrin concentration at the time of cancer diagnosis | At baseline |
| Complete surgery | The ability of progastrin kinetics during the neoadjuvant period to predict the outcome of the surgery (complete or not) will be analyzed by a ROC curve. If applicable. | 6 years |
| time to recurrence (for patients enrolled in curative intent cohorts). | The ability of the progastrin kinetics to predict recurrence free survival (curative cohorts), will be based on parameters estimated with a PK/PD model able to characterize the early kinetics of progastrin during and after the end of treatment and during follow up. | 6 years |
| time to progression (for patients enrolled in non-curative intent cohorts) | The ability of the progastrin kinetics to predict progression-free survival (non-curative cohorts) will be based on parameters estimated with a PK/PD model able to characterize the early kinetics of progastrin during and after the end of treatment and during follow up | 6 years |
| time to death (whenever it occurred) | The ability of the progastrin kinetics to predict time to death will be based on parameters estimated with a PK/PD model able to characterize the early kinetics of progastrin during and after the end of treatment and during follow up | 6 years |
| Comparison of the initial values and of the kinetics of other serum tumor markers (CA15-3, CA 19-9, CA125, CEA, PSA, AFP) with those of progastrin | The ROC AUC will be compared between classical markers and the prograstrin. Logistic regression will be used to combine the classical marker(s) and the progastrin in order to estimate the diagnostic value of the marker combination. progastrin, CA15-3, CA19-9, CA125, CEA, PSA and AFP concentration will be measured on blood sample taken at the inclusion. | at the baseline |
| Service d'ONCOLOGIE DIGESTIVE et HEPATOLOGIE de l'hôpital de la Croix-Rousse | Recruiting | Lyon | France |
|
| Service d'ONCOLOGIE DIGESTIVE et HEPATOLOGIE de l'Hôpital E. Herriot | Recruiting | Lyon | France |
|
| Service d'Oto-Rhino-Laryngologie de l'Hôpital de la Croix-Rousse | Recruiting | Lyon | France |
|
| Service d'Urologie de l'Hôpital E. Herriot | Recruiting | Lyon | France |
|
| Service de Gynécologie de l'hôpital de la Croix-Rousse | Recruiting | Lyon | France |
|
| Service de Gynécologie du Groupement Hospitalier Est | Recruiting | Lyon | France |
|
| Service de Pneumologie de l'hôpital de la Croix-Rousse | Recruiting | Lyon | France |
|
| Service de Pneumologie du Groupement Hospitalier Est | Recruiting | Lyon | France |
|
| Service d'Hématologie de l'Hôpital Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| Service d'ONCOLOGIE DIGESTIVE et HEPATOLOGIE du Centre Hospitalier Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| Service d'Oncologie médicale du Centre hospitalier Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| Service d'Urologie de l'hôpital Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| Service de Chirurgie de l'hôpital Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| Service de Dermatologie de l'hôpital Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| Service de Gynécologie de l'hôpital Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| Service de Pneumologie de l'Hôpital Lyon Sud | Recruiting | Pierre-Bénite | France |
|
| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D001943 | Breast Neoplasms |
| D013274 | Stomach Neoplasms |
| D007680 | Kidney Neoplasms |
| D011471 | Prostatic Neoplasms |
| D008545 | Melanoma |
| D008175 | Lung Neoplasms |
| D008113 | Liver Neoplasms |
| D015179 | Colorectal Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D010190 | Pancreatic Neoplasms |
| D010051 | Ovarian Neoplasms |
| D005909 | Glioblastoma |
| D016889 | Endometrial Neoplasms |
| D001749 | Urinary Bladder Neoplasms |
| D004938 | Esophageal Neoplasms |
| D016393 | Lymphoma, B-Cell |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |
| D005834 | Genital Neoplasms, Male |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D011469 | Prostatic Diseases |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009380 | Neoplasms, Nerve Tissue |
| D018326 | Nevi and Melanomas |
| D012878 | Skin Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D008107 | Liver Diseases |
| D007414 | Intestinal Neoplasms |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D005833 | Genital Neoplasms, Female |
| D006058 | Gonadal Disorders |
| D001254 | Astrocytoma |
| D005910 | Glioma |
| D018302 | Neoplasms, Neuroepithelial |
| D009375 | Neoplasms, Glandular and Epithelial |
| D014594 | Uterine Neoplasms |
| D014591 | Uterine Diseases |
| D001745 | Urinary Bladder Diseases |
| D004935 | Esophageal Diseases |
| D008228 | Lymphoma, Non-Hodgkin |
| D008223 | Lymphoma |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
Not provided
Not provided