Application of Vitamin E on Anal Fissure

Application of Vitamin E Acetate Ointment vs Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure

Patients were randomized into 2 groups:

• Vitamin E: Vitamin E ointment will be applied during 8 weeks
• Nitroglycerin: Nitroglycerin ointment will be applied during 8 weeks

Healing rate of chronic anal fissure in patients receiving Nitroglycerin ointment and subjects patients receiving Vitamin E ointment were evaluated .

Patients were randomly assigned to experimental and control groups: those patients receiving vitamin E ointment (Experimental Group - EG) and those receiving glyceryl trinitrate ointment (Control Group - CG).

Treatments:

Glyceryl trinitrate ointment (GTO): Commercially available aluminium tubes containing 0.4 glyceryl trinitrate ointment (Rectogesic, proStrakan Group, Galashiels, UK) were purchased from pharmacies. The dosage for all the patients was 375 mg of ointment (containing 1.5 mg of glyceryl trinitrate), applied with a gloved finger to the distal anal canal, every 12 hours for an 8-week period.

Vitamin E acetate ointment (VEA): Commercially available plastic tubes containing VitaminE acetate ointment (Filme Olio, Hulka SRL, Italy) were purchased from pharmacies. The dosage for all the patients was 1ml, applied with a gloved finger to the distal anal canal, every 12 hours for an 8-week period.

Healing rate of chronic anal fissure was investigated.

Inclusion Criteria:

• Patients with diagnosis of chronic anal fissure

Exclusion Criteria:

• patients with associated anal pathologies
• intestinal inflammation disorders
• immunosuppression
• fissures secondary to underlying diseases (eg, AIDS, tuberculosis, or sexually transmitted diseases)
• patients with a history of headaches, heart disease, or intolerance to nitrates
• pregnant or lactating women
• patients with closed angle glaucoma