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The main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.
To assess outcomes after cardiac surgery procedures. To investigate serum level of myeloperoxidase, morphology of left atrium appendage, to perform genetic analysis and cell biology.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| On-pump CABG. | Other | On-pump CABG. |
|
| Off-pump CABG. | Other | Off-pump CABG. |
|
| Pump-assisted CABG. | Other | Pump-assisted CABG. |
|
| Heart Valve Procedure without CABG. | Other | Heart Valve Procedure without CABG. |
|
| Heart Valve Procedure with CABG. | Other | Heart Valve Procedure with CABG. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| On-pump CABG | Other | On-pump CABG |
| |
| Off-pump CABG |
| Measure | Description | Time Frame |
|---|---|---|
| Death within 30 days after procedure. | Death within 30 days after surgical procedure. | within 30 days after procedure. |
| Acute myocardial infarction. | Acute myocardial infarction (ST-changes with troponin I > 10 ng/ml). | within 30 days after procedure. |
| Stroke. | Stroke (MRI changes or corresponding neurologist record). | within 30 days after procedure. |
| Arrhythmia | Any type of arrhythmia including AV-block. | within 30 days after procedure. |
| Renal dysfunction. | Renal dysfunction if serum creatinine greater than 25% of upper reference range. | within 30 days after procedure. |
| Infection or febrile. | Infection or febrile (t> 37 or CRP elevation or long regeneration of surgical wound). | within 30 days after procedure. |
| Respiratory dysfunction. | Respiratory dysfunction (pulmonary ventilation longer than 2 days). | within 30 days after procedure. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alexander Nemkov, PhD | Contact | +7-921-795-00-47 | nemk_as@mail.ru | |
| Vladimir Komok, PhD | Contact | +7-904-632-19-00 | vladimir_komok@mail.ru |
| Name | Affiliation | Role |
|---|---|---|
| Alexander Nemkov, PhD | First Saint-Petersburg Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nikolai Bunenkov | Recruiting | Saint Petersburg | Non-US/Non-Canadian | 194358 | Russia |
Individual participant data are confidential.
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| Other |
Off-pump CABG |
|
| Pump-assisted CABG | Other | Pump-assisted CABG |
|
| Valve Repair Procedure without CABG. | Other | Valve Repair Procedure without CABG (open heart procedure). |
|
| Valve Repair Procedure with CABG. | Other | Valve Repair Procedure with CABG (open heart procedure). |
|
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006349 | Heart Valve Diseases |
| D006343 | Heart Septal Defects |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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