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| ID | Type | Description | Link |
|---|---|---|---|
| R15MH116337 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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The impact of well-known risk factors for such disorders (stress, biological sex, anxiety-related dispositions) on fear generalization will be examined. Findings from this study may provide insight into how these risk factors influence the development and/or maintenance of psychological disorders that involve overgeneralization of fear and could facilitate future approaches to their treatment.
Many researchers approach the etiology of trauma-, stressor-, and anxiety-related mental disorders from the perspective of classical conditioning processes gone awry. According to this view, abnormal associative relationships between neutral, conditioned stimuli (CSs) and aversive, unconditioned stimuli (USs) underlie pathological anxiety and result in unusually intense fear memories or fear memories that cannot be properly extinguished. Recent work has expanded this view by showing that many psychological disorders involving pathological anxiety are associated with an exaggerated form of the commonly adaptive classical conditioning phenomenon, stimulus generalization, leading individuals with such disorders to respond with fear and anxiety to a variety of environmental contexts and cues that should not be threatening. Few studies have been conducted in humans to better understand the process of fear generalization, and factors that might influence susceptibility to overgeneralize fear have yet to be assessed. It is well-known that stress, biological sex, and anxiety-related dispositions of an individual increase one's susceptibility for pathological anxiety and significantly impact fear learning; thus, it is possible that such factors, alone or in combination, contribute to clinical anxiety by influencing fear generalization processes. Aim 1 of the present study is to determine the effects of acute stress and its physiological correlates on fear generalization in human participants. Because acute stress profoundly impacts cognitive brain areas that underlie generalization, it is predicted that acute stress will enhance or impair fear generalization, depending on when the stressor is administered relative to fear learning. Aim 2 is to assess the role of biological sex in fear generalization and acute stress-induced changes in such processes. Females are more likely than males to develop several psychological disorders that involve pathological anxiety, and research has consistently reported sex-related differences in fear learning and stress-induced alterations of fear learning, effects that have been associated with ovarian hormones. Thus, it is predicted that females will exhibit greater fear generalization than males that will be impacted differently by stress. It is also hypothesized that the observed effects will correlate with estradiol and progesterone in females. The final aim of this project (Aim 3) is to evaluate the relationship between childhood stress, dispositional anxiety, and fear generalization. Early life stress has been repeatedly associated with altered stress responses and the development of anxiety-related phenotypes, yet the influence of childhood stress and trait anxiety on fear generalization have yet to be examined. This study will be the first to examine how several factors that are known to increase susceptibility for trauma-, stressor, and anxiety-related psychological disorders impact fear generalization in human subjects. The resulting findings will provide important insight into the etiology of such disorders, which could aid future approaches to their treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stress, immediate, males | Experimental | Stress immediately before learning in males |
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| Stress, delayed, males | Experimental | Stress 30 minutes before learning in males |
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| Sham control, immediate, males | Sham Comparator | Sham control immediately before learning in males |
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| Sham control, delayed, males | Sham Comparator | Sham control 30 minutes before learning in males |
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| Stress, immediate, females | Experimental | Stress immediately before learning in females |
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| Stress, delayed, females | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stress immediately before learning in males | Behavioral | Male participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| Measure | Description | Time Frame |
|---|---|---|
| Fear-potentiated Startle Responses to the CS+ and CS- During Acquisition | Peak eyeblink startle responses 20-200 ms following presentation of a startle probe were measured. Startle responses were assessed for each of 3 trial types: (1) following the startle probe alone [noise alone (NA) trials], (2) following the CS+ and startle probe (CS+ trials), and (3) following the CS- and startle probe (CS- trials). Participants were exposed to 16 blocks of trials, and each block included 1 presentation of each trial type. During the last 12 blocks, CS+ trials also included the presentation of an aversive US. For each block, startle responses to NA trials were subtracted from startle responses to CS+ trials and from startle responses to CS- trials to create 2 separate fear-potentiated startle response measures: 1 for the CS+ and 1 for the CS-. Average fear-potentiated startle responses to the CS+ and CS- during the last 4 blocks of trials were used as an indicator of fear learning (greater responses to the CS+, relative to the CS-, indicated greater learning). | Average of the responses from trial block 13, trial block 14, trial block 15, and trial block 16 on Day 1 |
| EMG Responses to CS+, CS-, and Generalization Stimuli During Generalization Testing | Peak eyeblink startle responses 20-200 ms following the presentation of a startle probe were measured. Startle responses were assessed for each of 10 trial types: (1) following the startle probe alone [noise alone (NA) trials], (2) following the CS+ and startle probe (CS+ trials), (3) following each of 7 generalization stimuli and startle probe (GS trials), and (4) following the CS- and startle probe (CS- trials). Participants were exposed to 3 blocks of trials, and each block included 1 presentation of each trial type. For each block, startle responses to the NA trials were subtracted from startle responses to the CS+, GSs, and CS- trials to create separate fear-potentiated startle response measures for each of the 9 different stimuli. Average fear-potentiated startle responses to each stimulus across all 3 blocks were used as an indicator of fear expression. Greater scores for the generalization stimuli (GS) indicated a greater generalization of fear. | Average of responses from all trials on Day 2 |
| Skin Conductance Responses to CS+ and CS- During Acquisition |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Baseline Salivary Cortisol (Nmol/l) | Saliva samples were collected from participants prior to undergoing the stress or sham control condition (baseline) and then 25 min later. The change in salivary cortisol levels was analyzed. Greater levels indicated greater cortisol responses to stress. | Day 1 (change from baseline to 25 min post-stress) |
| Measure | Description | Time Frame |
|---|---|---|
| Salivary Estradiol (pg/ml) | Salivary estradiol (pg/ml) was measured by enzyme immunoassay (Salimetrics LLC) performed on saliva samples collected from female participants on Days 1 and 2. | Average across Day 1 (baseline) and Day 2 (baseline) |
| State Anxiety |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Phillip Zoladz, Ph.D. | Ohio Northern University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio Northern University | Ada | Ohio | 45810 | United States |
Raw data and data from descriptive/raw measures were submitted on a semi-annual basis to the NIMH Data Archive
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Data were shared on a semi-annual basis, beginning in January 2020.
NIMH Data Archive
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| ID | Title | Description |
|---|---|---|
| FG000 | Stress, Immediate, Males | Stress immediately before learning in males Stress immediately before learning in males: Male participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form | Oct 7, 2019 |
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Stress 30 minutes before learning in females |
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| Sham control, immediate, females | Sham Comparator | Sham control immediately before learning in females |
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| Sham control, delayed, females | Sham Comparator | Sham control 30 minutes before learning in females |
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| Sham control immediately before learning in males | Behavioral | Male participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
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| Stress 30 minutes before learning in males | Behavioral | Male participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
|
| Sham control 30 minutes before learning in males | Behavioral | Male participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
|
| Stress immediately before learning in females | Behavioral | Female participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
|
| Sham control immediately before learning in females | Behavioral | Female participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
|
| Stress 30 minutes before learning in females | Behavioral | Female participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
|
| Sham control 30 minutes before learning in females | Behavioral | Female participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
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Electrodermal activity was measured following presentation of the CS+ and CS- during acquisition on Day 1. Participants were exposed to 16 blocks of trials, with each block including a single presentation of each stimulus. During the last 12 blocks, CS+ trials included the presentation of an aversive US. For each block, skin conductance responses were quantified by calculating the average increase in electrodermal activity (from a 1 s pre-stimulus baseline) 3-6 s after CS+ or CS- onset. Average skin conductance responses to the CS+ and CS- during the last 4 blocks of trials were used as an indicator of fear learning (greater responses to the CS+, relative to the CS-, indicated greater learning). |
| Average of the responses from trial block 13, trial block 14, trial block 15, and trial block 16 on Day 1 |
| Skin Conductance Responses to CS+, Generalization Stimuli, and CS- During Generalization Testing | Electrodermal activity was measured following presentation of the CS+, 7 generalization stimuli (GSs), and CS- during generalization testing on Day 2. Participants were exposed to 3 blocks of trials, with each block including a single presentation of each stimulus. For each block, skin conductance responses were quantified by calculating the average increase in electrodermal activity (from a 1 s pre-stimulus baseline) 3-6 s after onset of the CS+, 7 GSs, or CS- onset.. Average skin conductance responses to each stimulus across all 3 blocks were used as an indicator of fear expression. Greater scores for the generalization stimuli (GS) indicated a greater generalization of fear. | Average of responses from all trials on Day 2 |
| US Expectancy Ratings to CS+ and CS- During Acquisition | Participants were exposed to 16 blocks of trials, and each block included 1 presentation of the CS+ and one presentation of the CS-. During the last 12 blocks, CS+ trials included the presentation of an aversive US. During each trial, participants pressed, within 3 seconds of stimulus onset, a button marked "+" if they expected the stimulus to be followed by the US, a button marked "-" if they did not expect the stimulus to be followed by the US, or a button marked "0" if they were uncertain. For the purpose of data analysis, + was scored as +1, - were scored as -1, and 0 was scored as 0. Average expectancy ratings during the last 4 blocks of trials were used as an indicator of fear learning (greater responses to the CS+, relative to the CS-, indicated greater learning). | Average of the ratings from trial block 13, trial block 14, trial block 15, and trial block 16 on Day 1 |
| US Expectancy Ratings to CS+, CS-, and Generalization Stimuli During Generalization Testing | Participants were exposed to 3 blocks of trials, and each block included 1 presentation of the CS+, one presentation of each of 7 generalization stimuli (GSs), and one presentation of the CS-. Participants were instructed to press, within 3 seconds of stimulus onset, a button marked "+" if they expected the stimulus to be followed by the US, a button marked "-" if they did not expect the stimulus to be followed by the US, or a button marked "0" if they were uncertain. For the purpose of data analysis, + was scored as +1, - was scored as -1, and 0 was scored as 0. Average expectancy ratings for each stimulus across all 3 blocks were used as an indicator of fear. Greater scores for the generalization stimuli (GS) indicated a greater generalization of fear. | Average of ratings from all trials on Day 2 |
| Change in Baseline Salivary Alpha-amylase (U/ml) | Saliva samples were collected from participants prior to undergoing the stress or sham control condition (baseline) and then immediately after the manipulation. The change in salivary alpha-amylase levels was analyzed. Greater levels indicated greater alpha-amylase responses to stress. | Day 1 (change from baseline to immediately after stress) |
| Average Subjective Pain, as Assessed by Verbal Self Report | During the stress or sham control manipulation, participants rated the painfulness of the water bath at 1-minute intervals on an 11-point scale ranging from 0-10, with 0 = lack of pain and 10 = unbearable pain. The obtained ratings were averaged and analyzed. Greater ratings indicated greater subjective pain during the stressor. | Stress or sham control condition on Day 1 |
| Average Subjective Stress, as Assessed by Verbal Self Report | During the stress or sham control manipulation, participants rated the stressfulness of the water bath at 1-minute intervals on an 11-point scale ranging from 0-10, with 0 = lack of stress and 10 = unbearable stress. The obtained ratings were averaged and analyzed. Greater ratings indicated greater subjective stress during the stressor. | Stress or sham control condition on Day 1 |
| Change in Heart Rate (Bpm) | Heart rate (bpm) measurements were aken via the PPG module of the Biopac MP150 system from participants prior to undergoing the stress or sham control condition (baseline) and then halfway through the manipulation.The change in heart rate was analyzed. | Day 1 (change from baseline to during stress or sham control manipulation) |
| Change in Salivary Progesterone (pg/ml) | Saliva samples were collected from female participants prior to undergoing the stress or sham control condition (baseline) and then 25 min later. The change in salivary progesterone levels were analyzed. | Day 1 (change from baseline to 25 min post-stress) |
The Spielberger State-Trait Anxiety Inventory (STAI) was administered following generalization testing on Day 2. The STAI provides scores (20-80) for state and trait anxiety. State anxiety was used for this measure and was a sum of 20 items from the STAI. The minimum score for state anxiety was 20, and the maximum score was 80. Higher scores represented higher levels of state anxiety.
| Day 2 - following generalization testing |
| Childhood Trauma Questionnaire (CTQ) | The Childhood Trauma Questionnaire (CTQ) was administered following generalization testing on Day 2. The questionnaire consists of 25 items and yields a score between 25 and 125. Higher scores represent greater levels of childhood trauma exposure. | Day 2 - following generalization testing |
| Anxiety Sensitivity Index | The Anxiety Sensitivity Index (ASI) was administered following generalization testing on Day 2. The ASI consists of 18 items and yields a score that reflects an individual's dispositional anxiety sensitivity. The minimum score is 0, and the maximum score is 72. Greater scores reflect a greater sensitivity to anxiety. | Day 2 - following generalization testing |
| Center for Epidemiological Studies Depression Scale (CES-D) | The Center for Epidemiological Studies Depression Scale (CES-D) was administered following generalization testing on Day 2. The CES-D is a 20-item measure of symptoms of depression. The possible range for scores is 0-60 with higher scores suggesting more severe symptoms of depression. | Day 2 - following generalization testing |
| PTSD Checklist - Civilian Version | The PTSD Checklist - Civilian Version was administered following generalization testing on Day 2. The checklist is a 17-item measure of symptoms of post-traumatic stress disorder (PTSD). The minimum score is 0, and the maximum score is 80. Greater scores reflect greater symptoms related to PTSD. | Day 2 - following generalization testing |
| FG001 | Stress, Delayed, Males | Stress 30 minutes before learning in males Stress 30 minutes before learning in males: Male participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| FG002 | Sham Control, Immediate, Males | Sham control immediately before learning in males Sham control immediately before learning in males: Male participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
| FG003 | Sham Control, Delayed, Males | Sham control 30 minutes before learning in males Sham control 30 minutes before learning in males: Male participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
| FG004 | Stress, Immediate, Females | Stress immediately before learning in females Stress immediately before learning in females: Female participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| FG005 | Stress, Delayed, Females | Stress 30 minutes before learning in females Stress 30 minutes before learning in females: Female participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| FG006 | Sham Control, Immediate, Females | Sham control immediately before learning in females Sham control immediately before learning in females: Female participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
| FG007 | Sham Control, Delayed, Females | Sham control 30 minutes before learning in females Sham control 30 minutes before learning in females: Female participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
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| NOT COMPLETED |
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| ID | Title | Description |
|---|---|---|
| BG000 | Stress, Immediate, Males | Stress immediately before learning in males Stress immediately before learning in males: Male participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| BG001 | Stress, Delayed, Males | Stress 30 minutes before learning in males Stress 30 minutes before learning in males: Male participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| BG002 | Sham Control, Immediate, Males | Sham control immediately before learning in males Sham control immediately before learning in males: Male participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
| BG003 | Sham Control, Delayed, Males | Sham control 30 minutes before learning in males Sham control 30 minutes before learning in males: Male participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
| BG004 | Stress, Immediate, Females | Stress immediately before learning in females Stress immediately before learning in females: Female participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| BG005 | Stress, Delayed, Females | Stress 30 minutes before learning in females Stress 30 minutes before learning in females: Female participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. |
| BG006 | Sham Control, Immediate, Females | Sham control immediately before learning in females Sham control immediately before learning in females: Female participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
| BG007 | Sham Control, Delayed, Females | Sham control 30 minutes before learning in females Sham control 30 minutes before learning in females: Female participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. |
| BG008 | Total | Total of all reporting groups |
| Units | Counts |
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| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||
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| Age, Continuous | Mean | Standard Deviation | years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Height | Mean | Standard Deviation | inches |
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| Weight | Mean | Standard Deviation | pounds |
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| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Primary | Fear-potentiated Startle Responses to the CS+ and CS- During Acquisition | Peak eyeblink startle responses 20-200 ms following presentation of a startle probe were measured. Startle responses were assessed for each of 3 trial types: (1) following the startle probe alone [noise alone (NA) trials], (2) following the CS+ and startle probe (CS+ trials), and (3) following the CS- and startle probe (CS- trials). Participants were exposed to 16 blocks of trials, and each block included 1 presentation of each trial type. During the last 12 blocks, CS+ trials also included the presentation of an aversive US. For each block, startle responses to NA trials were subtracted from startle responses to CS+ trials and from startle responses to CS- trials to create 2 separate fear-potentiated startle response measures: 1 for the CS+ and 1 for the CS-. Average fear-potentiated startle responses to the CS+ and CS- during the last 4 blocks of trials were used as an indicator of fear learning (greater responses to the CS+, relative to the CS-, indicated greater learning). | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some fear-potentiated startle responses were unable to be obtained from participants due to technical issues (e.g., poor electrode conductance). | Posted | Mean | Standard Error | Fear-potentiated startle (microvolts) | Average of the responses from trial block 13, trial block 14, trial block 15, and trial block 16 on Day 1 |
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| Primary | EMG Responses to CS+, CS-, and Generalization Stimuli During Generalization Testing | Peak eyeblink startle responses 20-200 ms following the presentation of a startle probe were measured. Startle responses were assessed for each of 10 trial types: (1) following the startle probe alone [noise alone (NA) trials], (2) following the CS+ and startle probe (CS+ trials), (3) following each of 7 generalization stimuli and startle probe (GS trials), and (4) following the CS- and startle probe (CS- trials). Participants were exposed to 3 blocks of trials, and each block included 1 presentation of each trial type. For each block, startle responses to the NA trials were subtracted from startle responses to the CS+, GSs, and CS- trials to create separate fear-potentiated startle response measures for each of the 9 different stimuli. Average fear-potentiated startle responses to each stimulus across all 3 blocks were used as an indicator of fear expression. Greater scores for the generalization stimuli (GS) indicated a greater generalization of fear. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some fear-potentiated startle responses were unable to be obtained from participants due to technical issues (e.g., poor electrode conductance). | Posted | Mean | Standard Error | Fear-potentiated startle (microvolts) | Average of responses from all trials on Day 2 |
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| Primary | Skin Conductance Responses to CS+ and CS- During Acquisition | Electrodermal activity was measured following presentation of the CS+ and CS- during acquisition on Day 1. Participants were exposed to 16 blocks of trials, with each block including a single presentation of each stimulus. During the last 12 blocks, CS+ trials included the presentation of an aversive US. For each block, skin conductance responses were quantified by calculating the average increase in electrodermal activity (from a 1 s pre-stimulus baseline) 3-6 s after CS+ or CS- onset. Average skin conductance responses to the CS+ and CS- during the last 4 blocks of trials were used as an indicator of fear learning (greater responses to the CS+, relative to the CS-, indicated greater learning). | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some skin conductance responses were unable to be obtained from participants due to technical issues (e.g., poor electrode conductance). | Posted | Mean | Standard Error | Skin conductance response (μSiemens) | Average of the responses from trial block 13, trial block 14, trial block 15, and trial block 16 on Day 1 |
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| Primary | Skin Conductance Responses to CS+, Generalization Stimuli, and CS- During Generalization Testing | Electrodermal activity was measured following presentation of the CS+, 7 generalization stimuli (GSs), and CS- during generalization testing on Day 2. Participants were exposed to 3 blocks of trials, with each block including a single presentation of each stimulus. For each block, skin conductance responses were quantified by calculating the average increase in electrodermal activity (from a 1 s pre-stimulus baseline) 3-6 s after onset of the CS+, 7 GSs, or CS- onset.. Average skin conductance responses to each stimulus across all 3 blocks were used as an indicator of fear expression. Greater scores for the generalization stimuli (GS) indicated a greater generalization of fear. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some skin conductance responses were unable to be obtained from participants due to technical issues (e.g., poor electrode conductance). | Posted | Mean | Standard Error | Skin conductance response (μSiemens) | Average of responses from all trials on Day 2 |
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| Primary | US Expectancy Ratings to CS+ and CS- During Acquisition | Participants were exposed to 16 blocks of trials, and each block included 1 presentation of the CS+ and one presentation of the CS-. During the last 12 blocks, CS+ trials included the presentation of an aversive US. During each trial, participants pressed, within 3 seconds of stimulus onset, a button marked "+" if they expected the stimulus to be followed by the US, a button marked "-" if they did not expect the stimulus to be followed by the US, or a button marked "0" if they were uncertain. For the purpose of data analysis, + was scored as +1, - were scored as -1, and 0 was scored as 0. Average expectancy ratings during the last 4 blocks of trials were used as an indicator of fear learning (greater responses to the CS+, relative to the CS-, indicated greater learning). | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some US expectancy ratings were unable to be obtained from participants due to technical issues (e.g., response pad malfunction) or participant error. | Posted | Mean | Standard Error | score on scale from -1 to +1 | Average of the ratings from trial block 13, trial block 14, trial block 15, and trial block 16 on Day 1 |
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| Primary | US Expectancy Ratings to CS+, CS-, and Generalization Stimuli During Generalization Testing | Participants were exposed to 3 blocks of trials, and each block included 1 presentation of the CS+, one presentation of each of 7 generalization stimuli (GSs), and one presentation of the CS-. Participants were instructed to press, within 3 seconds of stimulus onset, a button marked "+" if they expected the stimulus to be followed by the US, a button marked "-" if they did not expect the stimulus to be followed by the US, or a button marked "0" if they were uncertain. For the purpose of data analysis, + was scored as +1, - was scored as -1, and 0 was scored as 0. Average expectancy ratings for each stimulus across all 3 blocks were used as an indicator of fear. Greater scores for the generalization stimuli (GS) indicated a greater generalization of fear. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some US expectancy ratings were unable to be obtained from participants due to technical issues (e.g., response pad malfunction) or participant error. | Posted | Mean | Standard Error | score on scale from -1 to +1 | Average of ratings from all trials on Day 2 |
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| Secondary | Change in Baseline Salivary Cortisol (Nmol/l) | Saliva samples were collected from participants prior to undergoing the stress or sham control condition (baseline) and then 25 min later. The change in salivary cortisol levels was analyzed. Greater levels indicated greater cortisol responses to stress. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some salivary cortisol levels were unable to be obtained due to a lack of adequate saliva. | Posted | Mean | Standard Error | Change in cortisol (nmol/l) | Day 1 (change from baseline to 25 min post-stress) |
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| Secondary | Change in Baseline Salivary Alpha-amylase (U/ml) | Saliva samples were collected from participants prior to undergoing the stress or sham control condition (baseline) and then immediately after the manipulation. The change in salivary alpha-amylase levels was analyzed. Greater levels indicated greater alpha-amylase responses to stress. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some salivary cortisol levels were unable to be obtained due to a lack of adequate saliva. | Posted | Mean | Standard Error | Change in alpha-amylase (U/ml) | Day 1 (change from baseline to immediately after stress) |
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| Secondary | Average Subjective Pain, as Assessed by Verbal Self Report | During the stress or sham control manipulation, participants rated the painfulness of the water bath at 1-minute intervals on an 11-point scale ranging from 0-10, with 0 = lack of pain and 10 = unbearable pain. The obtained ratings were averaged and analyzed. Greater ratings indicated greater subjective pain during the stressor. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some participants did not report subjective pain ratings. | Posted | Mean | Standard Error | score on a scale of 0-10 | Stress or sham control condition on Day 1 |
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| Secondary | Average Subjective Stress, as Assessed by Verbal Self Report | During the stress or sham control manipulation, participants rated the stressfulness of the water bath at 1-minute intervals on an 11-point scale ranging from 0-10, with 0 = lack of stress and 10 = unbearable stress. The obtained ratings were averaged and analyzed. Greater ratings indicated greater subjective stress during the stressor. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some participants did not report subjective stress ratings. | Posted | Mean | Standard Error | score on scale of 0-10 | Stress or sham control condition on Day 1 |
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| Secondary | Change in Heart Rate (Bpm) | Heart rate (bpm) measurements were aken via the PPG module of the Biopac MP150 system from participants prior to undergoing the stress or sham control condition (baseline) and then halfway through the manipulation.The change in heart rate was analyzed. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some heart rate measurements were unable to be obtained from participants due to technical issues (e.g., pulse oximeter malfunction). | Posted | Mean | Standard Error | Change in heart rate (beats per minute) | Day 1 (change from baseline to during stress or sham control manipulation) |
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| Secondary | Change in Salivary Progesterone (pg/ml) | Saliva samples were collected from female participants prior to undergoing the stress or sham control condition (baseline) and then 25 min later. The change in salivary progesterone levels were analyzed. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some salivary cortisol levels were unable to be obtained due to a lack of adequate saliva. | Posted | Mean | Standard Error | Change in progesterone (pg/ml) | Day 1 (change from baseline to 25 min post-stress) |
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| Other Pre-specified | Salivary Estradiol (pg/ml) | Salivary estradiol (pg/ml) was measured by enzyme immunoassay (Salimetrics LLC) performed on saliva samples collected from female participants on Days 1 and 2. | Posted | Mean | Standard Error | pg/ml | Average across Day 1 (baseline) and Day 2 (baseline) |
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| Other Pre-specified | State Anxiety | The Spielberger State-Trait Anxiety Inventory (STAI) was administered following generalization testing on Day 2. The STAI provides scores (20-80) for state and trait anxiety. State anxiety was used for this measure and was a sum of 20 items from the STAI. The minimum score for state anxiety was 20, and the maximum score was 80. Higher scores represented higher levels of state anxiety. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some participants did not complete the questionnaire. | Posted | Mean | Standard Error | score on a scale of 20-80 | Day 2 - following generalization testing |
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| Other Pre-specified | Childhood Trauma Questionnaire (CTQ) | The Childhood Trauma Questionnaire (CTQ) was administered following generalization testing on Day 2. The questionnaire consists of 25 items and yields a score between 25 and 125. Higher scores represent greater levels of childhood trauma exposure. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some participants did not complete the questionnaire. | Posted | Mean | Standard Error | score on a scale of 25-125 | Day 2 - following generalization testing |
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| Other Pre-specified | Anxiety Sensitivity Index | The Anxiety Sensitivity Index (ASI) was administered following generalization testing on Day 2. The ASI consists of 18 items and yields a score that reflects an individual's dispositional anxiety sensitivity. The minimum score is 0, and the maximum score is 72. Greater scores reflect a greater sensitivity to anxiety. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some participants did not complete the questionnaire. | Posted | Mean | Standard Error | score on a scale of 0-72 | Day 2 - following generalization testing |
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| Other Pre-specified | Center for Epidemiological Studies Depression Scale (CES-D) | The Center for Epidemiological Studies Depression Scale (CES-D) was administered following generalization testing on Day 2. The CES-D is a 20-item measure of symptoms of depression. The possible range for scores is 0-60 with higher scores suggesting more severe symptoms of depression. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some participants did not complete the questionnaire. | Posted | Mean | Standard Error | score of a scale of 0-60 | Day 2 - following generalization testing |
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| Other Pre-specified | PTSD Checklist - Civilian Version | The PTSD Checklist - Civilian Version was administered following generalization testing on Day 2. The checklist is a 17-item measure of symptoms of post-traumatic stress disorder (PTSD). The minimum score is 0, and the maximum score is 80. Greater scores reflect greater symptoms related to PTSD. | The overall number of participants analyzed is not consistent with the numbers in the participant flow module. Some participants did not complete the questionnaire. | Posted | Mean | Standard Error | score on a scale of 0-80 | Day 2 - following generalization testing |
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2 days, the length of the time of in-person experimental sessions
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Stress, Immediate, Males | Stress immediately before learning in males Stress immediately before learning in males: Male participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. | 0 | 56 | 0 | 56 | 0 | 56 |
| EG001 | Stress, Delayed, Males | Stress 30 minutes before learning in males Stress 30 minutes before learning in males: Male participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. | 0 | 59 | 0 | 59 | 0 | 59 |
| EG002 | Sham Control, Immediate, Males | Sham control immediately before learning in males Sham control immediately before learning in males: Male participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. | 0 | 58 | 0 | 58 | 0 | 58 |
| EG003 | Sham Control, Delayed, Males | Sham control 30 minutes before learning in males Sham control 30 minutes before learning in males: Male participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. | 0 | 57 | 0 | 57 | 0 | 57 |
| EG004 | Stress, Immediate, Females | Stress immediately before learning in females Stress immediately before learning in females: Female participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning. | 0 | 97 | 0 | 97 | 0 | 97 |
| EG005 | Stress, Delayed, Females | Stress 30 minutes before learning in females Stress 30 minutes before learning in females: Female participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning. | 0 | 87 | 0 | 87 | 0 | 87 |
| EG006 | Sham Control, Immediate, Females | Sham control immediately before learning in females Sham control immediately before learning in females: Female participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning. | 0 | 94 | 0 | 94 | 0 | 94 |
| EG007 | Sham Control, Delayed, Females | Sham control 30 minutes before learning in females Sham control 30 minutes before learning in females: Female participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning. | 0 | 98 | 0 | 98 | 0 | 98 |
Not provided
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Phillip Zoladz | Ohio Northern University | 419-772-2142 | p-zoladz@onu.edu |
| Jan 13, 2023 |
| Prot_SAP_ICF_000.pdf |
| ID | Term |
|---|---|
| D013315 | Stress, Psychological |
| D003075 | Coitus |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D012725 | Sexual Behavior |
Not provided
Not provided
| Male |
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| Not Hispanic or Latino |
|
| Unknown or Not Reported |
|
| Asian |
|
| Native Hawaiian or Other Pacific Islander |
|
| Black or African American |
|
| White |
|
| More than one race |
|
| Unknown or Not Reported |
|
Fear-potentiated startle responses to the CS+ during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation 30 min before learning
| OG007 | Sham Control, Delayed, Males, CS- | Fear-potentiated startle responses to the CS- during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG008 | Stress, Immediate, Females, CS+ | Fear-potentiated startle responses to the CS+ during the conditioning phase of acquisition on Day 1 in females stressed immediately before learning |
| OG009 | Stress, Immediate, Females, CS- | Fear-potentiated startle responses to the CS- during the conditioning phase of acquisition on Day 1 in females stressed immediately before learning |
| OG010 | Stress, Delayed, Females, CS+ | Fear-potentiated startle responses to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to stress 30 min before learning |
| OG011 | Stress, Delayed, Females, CS- | Fear-potentiated startle responses to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to stress 30 min before learning |
| OG012 | Sham Control, Immediate, Females, CS+ | Fear-potentiated startle responses to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG013 | Sham Control, Immediate, Females, CS- | Fear-potentiated startle responses to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG014 | Sham Control, Delayed, Females, CS+ | Fear-potentiated startle responses to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation 30 min before learning |
| OG015 | Sham Control, Delayed, Females, CS- | Fear-potentiated startle responses to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation 30 min before learning |
| Stress, Immediate, Males, GS1 |
Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in males stressed immediately before learning |
| OG002 | Stress, Immediate, Males, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in males stressed immediately before learning |
| OG003 | Stress, Immediate, Males, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in males stressed immediately before learning |
| OG004 | Stress, Immediate, Males, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in males stressed immediately before learning |
| OG005 | Stress, Immediate, Males, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in males stressed immediately before learning |
| OG006 | Stress, Immediate, Males, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in males stressed immediately before learning |
| OG007 | Stress, Immediate, Males, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in males stressed immediately before learning |
| OG008 | Stress, Immediate, Males, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in males stressed immediately before learning |
| OG009 | Stress, Delayed, Males, CS+ | Fear-potentiated startle responses to the CS+ during generalization testing on Day 2 in males stressed 30 min before learning |
| OG010 | Stress, Delayed, Males, GS1 | Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG011 | Stress, Delayed, Males, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG012 | Stress, Delayed, Males, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG013 | Stress, Delayed, Males, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG014 | Stress, Delayed, Males, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG015 | Stress, Delayed, Males, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG016 | Stress, Delayed, Males, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG017 | Stress, Delayed, Males, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in males stressed 30 min before learning |
| OG018 | Sham Control, Immediate, Males, CS+ | Fear-potentiated startle responses to the CS+ during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG019 | Sham Control, Immediate, Males, GS1 | Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG020 | Sham Control, Immediate, Males, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG021 | Sham Control, Immediate, Males, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG022 | Sham Control, Immediate, Males, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG023 | Sham Control, Immediate, Males, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG024 | Sham Control, Immediate, Males, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG025 | Sham Control, Immediate, Males, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG026 | Sham Control, Immediate, Males, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG027 | Sham Control, Delayed, Males, CS+ | Fear-potentiated startle responses to the CS+ during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG028 | Sham Control, Delayed, Males, GS1 | Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG029 | Sham Control, Delayed, Males, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG030 | Sham Control, Delayed, Males, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG031 | Sham Control, Delayed, Males, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG032 | Sham Control, Delayed, Males, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG033 | Sham Control, Delayed, Males, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG034 | Sham Control, Delayed, Males, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG035 | Sham Control, Delayed, Males, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG036 | Stress, Immediate, Females, CS+ | Fear-potentiated startle responses to the CS+ during generalization testing on Day 2 in females stressed immediately before learning |
| OG037 | Stress, Immediate, Females, GS1 | Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in females stressed immediately before learning |
| OG038 | Stress, Immediate, Females, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in females stressed immediately before learning |
| OG039 | Stress, Immediate, Females, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in females stressed immediately before learning |
| OG040 | Stress, Immediate, Females, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in females stressed immediately before learning |
| OG041 | Stress, Immediate, Females, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in females stressed immediately before learning |
| OG042 | Stress, Immediate, Females, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in females stressed immediately before learning |
| OG043 | Stress, Immediate, Females, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in females stressed immediately before learning |
| OG044 | Stress, Immediate, Females, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in females stressed immediately before learning |
| OG045 | Stress, Delayed, Females, CS+ | Fear-potentiated startle responses to the CS+ during generalization testing on Day 2 in females stressed 30 min before learning |
| OG046 | Stress, Delayed, Females, GS1 | Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG047 | Stress, Delayed, Females, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG048 | Stress, Delayed, Females, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG049 | Stress, Delayed, Females, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG050 | Stress, Delayed, Females, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG051 | Stress, Delayed, Females, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG052 | Stress, Delayed, Females, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG053 | Stress, Delayed, Females, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in females stressed 30 min before learning |
| OG054 | Sham Control, Immediate, Females, CS+ | Fear-potentiated startle responses to the CS+ during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG055 | Sham Control, Immediate, Females, GS1 | Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG056 | Sham Control, Immediate, Females, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG057 | Sham Control, Immediate, Females, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG058 | Sham Control, Immediate, Females, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG059 | Sham Control, Immediate, Females, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG060 | Sham Control, Immediate, Females, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG061 | Sham Control, Immediate, Females, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG062 | Sham Control, Immediate, Females, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG063 | Sham Control, Delayed, Females, CS+ | Fear-potentiated startle responses to the CS+ during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG064 | Sham Control, Delayed, Females, GS1 | Fear-potentiated startle responses to the GS1 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG065 | Sham Control, Delayed, Females, GS2 | Fear-potentiated startle responses to the GS2 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG066 | Sham Control, Delayed, Females, GS3 | Fear-potentiated startle responses to the GS3 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG067 | Sham Control, Delayed, Females, GS4 | Fear-potentiated startle responses to the GS4 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG068 | Sham Control, Delayed, Females, GS5 | Fear-potentiated startle responses to the GS5 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG069 | Sham Control, Delayed, Females, GS6 | Fear-potentiated startle responses to the GS6 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG070 | Sham Control, Delayed, Females, GS7 | Fear-potentiated startle responses to the GS7 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG071 | Sham Control, Delayed, Females, CS- | Fear-potentiated startle responses to the CS- during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
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| OG002 | Stress, Delayed, Males, CS+ | Skin conductance responses to the CS+ during the conditioning phase of acquisition on Day 1 in males stressed 30 min before learning |
| OG003 | Stress, Delayed, Males, CS- | Skin conductance responses to the CS- during the conditioning phase of acquisition on Day 1 in males stressed 30 min before learning |
| OG004 | Sham Control, Immediate, Males, CS+ | Skin conductance responses to the CS+ during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation immediately before learning |
| OG005 | Sham Control, Immediate, Males, CS- | Skin conductance responses to the CS- during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation immediately before learning |
| OG006 | Sham Control, Delayed, Males, CS+ | Skin conductance responses to the CS+ during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG007 | Sham Control, Delayed, Males, CS- | Skin conductance responses to the CS- during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG008 | Stress, Immediate, Females, CS+ | Skin conductance responses to the CS+ during the conditioning phase of acquisition on Day 1 in females stressed immediately before learning |
| OG009 | Stress, Immediate, Females, CS- | Skin conductance responses to the CS- during the conditioning phase of acquisition on Day 1 in females stressed immediately before learning |
| OG010 | Stress, Delayed, Females, CS+ | Skin conductance responses to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to stress 30 min before learning |
| OG011 | Stress, Delayed, Females, CS- | Skin conductance responses to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to stress 30 min before learning |
| OG012 | Sham Control, Immediate, Females, CS+ | Skin conductance responses to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG013 | Sham Control, Immediate, Females, CS- | Skin conductance responses to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG014 | Sham Control, Delayed, Females, CS+ | Skin conductance responses to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation 30 min before learning |
| OG015 | Sham Control, Delayed, Females, CS- | Skin conductance responses to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
| OG002 | Stress, Immediate, Males, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in males stressed immediately before learning |
| OG003 | Stress, Immediate, Males, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in males stressed immediately before learning |
| OG004 | Stress, Immediate, Males, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in males stressed immediately before learning |
| OG005 | Stress, Immediate, Males, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in males stressed immediately before learning |
| OG006 | Stress, Immediate, Males, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in males stressed immediately before learning |
| OG007 | Stress, Immediate, Males, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in males stressed immediately before learning |
| OG008 | Stress, Immediate, Males, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in males stressed immediately before learning |
| OG009 | Stress, Delayed, Males, CS+ | Skin conductance responses to the CS+ during generalization testing on Day 2 in males stressed 30 min before learning |
| OG010 | Stress, Delayed, Males, GS1 | Skin conductance responses to the GS1 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG011 | Stress, Delayed, Males, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG012 | Stress, Delayed, Males, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG013 | Stress, Delayed, Males, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG014 | Stress, Delayed, Males, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG015 | Stress, Delayed, Males, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG016 | Stress, Delayed, Males, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG017 | Stress, Delayed, Males, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in males stressed 30 min before learning |
| OG018 | Sham Control, Immediate, Males, CS+ | Skin conductance responses to the CS+ during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG019 | Sham Control, Immediate, Males, GS1 | Skin conductance responses to the GS1 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG020 | Sham Control, Immediate, Males, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG021 | Sham Control, Immediate, Males, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG022 | Sham Control, Immediate, Males, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG023 | Sham Control, Immediate, Males, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG024 | Sham Control, Immediate, Males, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG025 | Sham Control, Immediate, Males, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG026 | Sham Control, Immediate, Males, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG027 | Sham Control, Delayed, Males, CS+ | Skin conductance responses to the CS+ during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG028 | Sham Control, Delayed, Males, GS1 | Skin conductance responses to the GS1 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG029 | Sham Control, Delayed, Males, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG030 | Sham Control, Delayed, Males, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG031 | Sham Control, Delayed, Males, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG032 | Sham Control, Delayed, Males, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG033 | Sham Control, Delayed, Males, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG034 | Sham Control, Delayed, Males, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG035 | Sham Control, Delayed, Males, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG036 | Stress, Immediate, Females, CS+ | Skin conductance responses to the CS+ during generalization testing on Day 2 in females stressed immediately before learning |
| OG037 | Stress, Immediate, Females, GS1 | Skin conductance responses to the GS1 during generalization testing on Day 2 in females stressed immediately before learning |
| OG038 | Stress, Immediate, Females, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in females stressed immediately before learning |
| OG039 | Stress, Immediate, Females, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in females stressed immediately before learning |
| OG040 | Stress, Immediate, Females, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in females stressed immediately before learning |
| OG041 | Stress, Immediate, Females, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in females stressed immediately before learning |
| OG042 | Stress, Immediate, Females, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in females stressed immediately before learning |
| OG043 | Stress, Immediate, Females, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in females stressed immediately before learning |
| OG044 | Stress, Immediate, Females, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in females stressed immediately before learning |
| OG045 | Stress, Delayed, Females, CS+ | Skin conductance responses to the CS+ during generalization testing on Day 2 in females stressed 30 min before learning |
| OG046 | Stress, Delayed, Females, GS1 | Skin conductance responses to the GS1 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG047 | Stress, Delayed, Females, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG048 | Stress, Delayed, Females, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG049 | Stress, Delayed, Females, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG050 | Stress, Delayed, Females, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG051 | Stress, Delayed, Females, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG052 | Stress, Delayed, Females, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG053 | Stress, Delayed, Females, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in females stressed 30 min before learning |
| OG054 | Sham Control, Immediate, Females, CS+ | Skin conductance responses to the CS+ during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG055 | Sham Control, Immediate, Females, GS1 | Skin conductance responses to the GS1 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG056 | Sham Control, Immediate, Females, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG057 | Sham Control, Immediate, Females, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG058 | Sham Control, Immediate, Females, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG059 | Sham Control, Immediate, Females, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG060 | Sham Control, Immediate, Females, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG061 | Sham Control, Immediate, Females, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG062 | Sham Control, Immediate, Females, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG063 | Sham Control, Delayed, Females, CS+ | Skin conductance responses to the CS+ during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG064 | Sham Control, Delayed, Females, GS1 | Skin conductance responses to the GS1 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG065 | Sham Control, Delayed, Females, GS2 | Skin conductance responses to the GS2 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG066 | Sham Control, Delayed, Females, GS3 | Skin conductance responses to the GS3 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG067 | Sham Control, Delayed, Females, GS4 | Skin conductance responses to the GS4 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG068 | Sham Control, Delayed, Females, GS5 | Skin conductance responses to the GS5 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG069 | Sham Control, Delayed, Females, GS6 | Skin conductance responses to the GS6 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG070 | Sham Control, Delayed, Females, GS7 | Skin conductance responses to the GS7 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG071 | Sham Control, Delayed, Females, CS- | Skin conductance responses to the CS- during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
|
|
|
US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in males stressed immediately before learning
| OG002 | Stress, Delayed, Males, CS+ | US expectancy ratings to the CS+ during the conditioning phase of acquisition on Day 1 in males stressed 30 min before learning |
| OG003 | Stress, Delayed, Males, CS- | US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in males stressed 30 min before learning |
| OG004 | Sham Control, Immediate, Males, CS+ | US expectancy ratings to the CS+ during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation immediately before learning |
| OG005 | Sham Control, Immediate, Males, CS- | US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation immediately before learning |
| OG006 | Sham Control, Delayed, Males, CS+ | US expectancy ratings to the CS+ during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG007 | Sham Control, Delayed, Males, CS- | US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG008 | Stress, Immediate, Females, CS+ | US expectancy ratings to the CS+ during the conditioning phase of acquisition on Day 1 in females stressed immediately before learning |
| OG009 | Stress, Immediate, Females, CS- | US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in females stressed immediately before learning |
| OG010 | Stress, Delayed, Females, CS+ | US expectancy ratings to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to stress 30 min before learning |
| OG011 | Stress, Delayed, Females, CS- | US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to stress 30 min before learning |
| OG012 | Sham Control, Immediate, Females, CS+ | US expectancy ratings to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG013 | Sham Control, Immediate, Females, CS- | US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG014 | Sham Control, Delayed, Females, CS+ | US expectancy ratings to the CS+ during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation 30 min before learning |
| OG015 | Sham Control, Delayed, Females, CS- | US expectancy ratings to the CS- during the conditioning phase of acquisition on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
| OG002 | Stress, Immediate, Males, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in males stressed immediately before learning |
| OG003 | Stress, Immediate, Males, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in males stressed immediately before learning |
| OG004 | Stress, Immediate, Males, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in males stressed immediately before learning |
| OG005 | Stress, Immediate, Males, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in males stressed immediately before learning |
| OG006 | Stress, Immediate, Males, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in males stressed immediately before learning |
| OG007 | Stress, Immediate, Males, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in males stressed immediately before learning |
| OG008 | Stress, Immediate, Males, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in males stressed immediately before learning |
| OG009 | Stress, Delayed, Males, CS+ | US expectancy ratings to the CS+ during generalization testing on Day 2 in males stressed 30 min before learning |
| OG010 | Stress, Delayed, Males, GS1 | US expectancy ratings to the GS1 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG011 | Stress, Delayed, Males, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG012 | Stress, Delayed, Males, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG013 | Stress, Delayed, Males, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG014 | Stress, Delayed, Males, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG015 | Stress, Delayed, Males, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG016 | Stress, Delayed, Males, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in males stressed 30 min before learning |
| OG017 | Stress, Delayed, Males, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in males stressed 30 min before learning |
| OG018 | Sham Control, Immediate, Males, CS+ | US expectancy ratings to the CS+ during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG019 | Sham Control, Immediate, Males, GS1 | US expectancy ratings to the GS1 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG020 | Sham Control, Immediate, Males, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG021 | Sham Control, Immediate, Males, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG022 | Sham Control, Immediate, Males, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG023 | Sham Control, Immediate, Males, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG024 | Sham Control, Immediate, Males, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG025 | Sham Control, Immediate, Males, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG026 | Sham Control, Immediate, Males, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in males exposed to the sham manipulation immediately before learning |
| OG027 | Sham Control, Delayed, Males, CS+ | US expectancy ratings to the CS+ during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG028 | Sham Control, Delayed, Males, GS1 | US expectancy ratings to the GS1 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG029 | Sham Control, Delayed, Males, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG030 | Sham Control, Delayed, Males, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG031 | Sham Control, Delayed, Males, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG032 | Sham Control, Delayed, Males, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG033 | Sham Control, Delayed, Males, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG034 | Sham Control, Delayed, Males, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG035 | Sham Control, Delayed, Males, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in males exposed to the sham manipulation 30 min before learning |
| OG036 | Stress, Immediate, Females, CS+ | US expectancy ratings to the CS+ during generalization testing on Day 2 in females stressed immediately before learning |
| OG037 | Stress, Immediate, Females, GS1 | US expectancy ratings to the GS1 during generalization testing on Day 2 in females stressed immediately before learning |
| OG038 | Stress, Immediate, Females, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in females stressed immediately before learning |
| OG039 | Stress, Immediate, Females, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in females stressed immediately before learning |
| OG040 | Stress, Immediate, Females, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in females stressed immediately before learning |
| OG041 | Stress, Immediate, Females, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in females stressed immediately before learning |
| OG042 | Stress, Immediate, Females, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in females stressed immediately before learning |
| OG043 | Stress, Immediate, Females, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in females stressed immediately before learning |
| OG044 | Stress, Immediate, Females, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in females stressed immediately before learning |
| OG045 | Stress, Delayed, Females, CS+ | US expectancy ratings to the CS+ during generalization testing on Day 2 in females stressed 30 min before learning |
| OG046 | Stress, Delayed, Females, GS1 | US expectancy ratings to the GS1 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG047 | Stress, Delayed, Females, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG048 | Stress, Delayed, Females, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG049 | Stress, Delayed, Females, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG050 | Stress, Delayed, Females, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG051 | Stress, Delayed, Females, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG052 | Stress, Delayed, Females, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in females stressed 30 min before learning |
| OG053 | Stress, Delayed, Females, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in females stressed 30 min before learning |
| OG054 | Sham Control, Immediate, Females, CS+ | US expectancy ratings to the CS+ during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG055 | Sham Control, Immediate, Females, GS1 | US expectancy ratings to the GS1 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG056 | Sham Control, Immediate, Females, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG057 | Sham Control, Immediate, Females, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG058 | Sham Control, Immediate, Females, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG059 | Sham Control, Immediate, Females, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG060 | Sham Control, Immediate, Females, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG061 | Sham Control, Immediate, Females, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG062 | Sham Control, Immediate, Females, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in females exposed to the sham manipulation immediately before learning |
| OG063 | Sham Control, Delayed, Females, CS+ | US expectancy ratings to the CS+ during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG064 | Sham Control, Delayed, Females, GS1 | US expectancy ratings to the GS1 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG065 | Sham Control, Delayed, Females, GS2 | US expectancy ratings to the GS2 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG066 | Sham Control, Delayed, Females, GS3 | US expectancy ratings to the GS3 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG067 | Sham Control, Delayed, Females, GS4 | US expectancy ratings to the GS4 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG068 | Sham Control, Delayed, Females, GS5 | US expectancy ratings to the GS5 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG069 | Sham Control, Delayed, Females, GS6 | US expectancy ratings to the GS6 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG070 | Sham Control, Delayed, Females, GS7 | US expectancy ratings to the GS7 during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
| OG071 | Sham Control, Delayed, Females, CS- | US expectancy ratings to the CS- during generalization testing on Day 2 in females exposed to the sham manipulation 30 min before learning |
|
|
|
Change in salivary cortisol levels on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Change in salivary cortisol levels on Day 1 in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Change in salivary cortisol levels on Day 1 in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Change in salivary cortisol levels on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Change in salivary cortisol levels on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
| Sham Control, Delayed, Males |
Change in salivary alpha-amylase levels on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Change in salivary alpha-amylase levels on Day 1 in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Change in salivary alpha-amylase levels on Day 1 in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Change in salivary alpha-amylase levels on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Change in salivary alpha-amylase levels on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
Average pain ratings on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Average pain ratings on Day 1 in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Average pain ratings on Day 1 in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Average pain ratings on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Average pain ratings on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
| Sham Control, Delayed, Males |
Average stress ratings on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Average stress ratings on Day 1 in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Average stress ratings on Day 1 in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Average stress ratings on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Average stress ratings on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
| Sham Control, Delayed, Males |
Change in heart rate on Day 1 in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Change in heart rate on Day 1 in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Change in heart rate on Day 1 in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Change in heart rate on Day 1 in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Change in heart rate on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
Change in salivary progesterone levels on Day 1 in females exposed to the sham manipulation 30 min before learning |
|
|
|
| Units | Counts |
|---|
| Participants |
|
|
|
Average state anxiety in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Average state anxiety in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Average state anxiety in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Average state anxiety in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Average state anxiety in females exposed to the sham manipulation 30 min before learning |
|
|
|
| OG004 | Stress, Immediate, Females | Total CTQ score in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Total CTQ score in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Total CTQ score in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Total CTQ score in females exposed to the sham manipulation 30 min before learning |
|
|
|
Average anxiety sensitivity in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Average anxiety sensitivity in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Average anxiety sensitivity in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Average anxiety sensitivity in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Average anxiety sensitivity in females exposed to the sham manipulation 30 min before learning |
|
|
|
Average CES-D score in males exposed to the sham manipulation 30 min before learning |
| OG004 | Stress, Immediate, Females | Average CES-D score in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Average CES-D score in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Average CES-D score in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Average CES-D score in females exposed to the sham manipulation 30 min before learning |
|
|
|
Average PTSD score in males exposed to the sham manipulation 30 min before learning
| OG004 | Stress, Immediate, Females | Average PTSD score in females stressed immediately before learning |
| OG005 | Stress, Delayed, Females | Average PTSD score in females exposed to stress 30 min before learning |
| OG006 | Sham Control, Immediate, Females | Average PTSD score in females exposed to the sham manipulation immediately before learning |
| OG007 | Sham Control, Delayed, Females | Average PTSD score in females exposed to the sham manipulation 30 min before learning |
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