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The fatty acid composition in blood and subcutaneous adipose tissue of infants that have an clinical indicated operation is studied.
Collection of:
Measurement of the fatty acid composition (especially arachidonic acid and docosahexaenoic acid) in subcutaneous adipose tissue and blood.
Aim is to compare the composition of the fatty acids in blood and adipose tissue of preterms at term and term infants. To calculate the fatty acid value in each infant the proportion of adipose tissue is determined with PEAPOD before discharge from hospital.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| preterms with enterostomy | GA 23±0/7 - 31±6/7 with clinically indicated operations because of NEC (necrotising enterocolitis) or FIP (focal intestinal perforation). Operation after birth (within 14 days) and at term (enterostomy closure) Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD) |
| |
| preterms without enterostomy | GA 23±0/7 bis 31±6/7 with a clinically indicated operation (e.g. herniotomy) at term, without any abdominal problems. Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD) |
| |
| term infants | GA ≥34±0/7 with a clinically indicated operation directly after birth (within 14 days) (e.g. gastroschisis). Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| adipose tissue | Other | taking a sample of the adipose tissue during operation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fatty acid composition of the subcutaneous adipose tissue and plasma | Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms at term compared to the composition of infants after birth (within 14 days). | at the time of the operation |
| Measure | Description | Time Frame |
|---|---|---|
| Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms with abdominal problems | Change of fatty acid composition of the subcutaneous tissue and plasma from first to second operation in preterms with abdominal operations, enterostomy | time of the first operation until discharge home (at a postnatal age of up to 4-5 months at the most in very preterm infants) |
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Inclusion Criteria:
Exclusion Criteria:
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term and preterm neonates
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Katrin Böckmann | Contact | +49707129 | 82621 | katrin.boeckmann@med.uni-tuebingen.de |
| Axel Franz, MD | Contact | +49707129 | 83791 | axel.franz@med.uni-tuebingen.de |
| Name | Affiliation | Role |
|---|---|---|
| Axel Franz | University Hospital Tuebingen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Tuebingen | Recruiting | Tübingen | 72076 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32476053 | Derived | Bockmann KA, von Stumpff A, Bernhard W, Shunova A, Minarski M, Frische B, Warmann S, Schleicher E, Poets CF, Franz AR. Fatty acid composition of adipose tissue at term indicates deficiency of arachidonic and docosahexaenoic acid and excessive linoleic acid supply in preterm infants. Eur J Nutr. 2021 Mar;60(2):861-872. doi: 10.1007/s00394-020-02293-2. Epub 2020 May 31. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| blood | Other | taking a blood sample when a peripheral venous catheter is inserted before operation |
|
| PEAPOD | Diagnostic Test | Measurement of the total adipose tissue of the infant with PEAPOD (Air Displacement-Plethysmography, Infant Body Composition System, Cosmed, Rome, Italy) |
|
| Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms with abdominal problems and preterms without abdominal problems at term | Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms at term compared to the composition of preterms at term with enterostomy. | time of the first operation until discharge home (at a postnatal age of up to 4-5 months at the most in very preterm infants) |
| D000091642 | Urogenital Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |