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| ID | Type | Description | Link |
|---|---|---|---|
| CA239-0008 | Other Identifier | Bristol-Myers Squibb Protocol ID | |
| 849-001 | Other Identifier | Mirati Therapeutics Protocol ID |
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This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
This study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 (adagrasib) is an orally-available small molecule inhibitor of KRAS G12C.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phase 1 Dose Exploration | Experimental | Dose escalation of MRTX849 to determine maximum tolerated dose |
|
| Phase 1b Expansion | Experimental | Expansion cohort to ensure sufficient safety experience, pharmacokinetic information, and early evidence of clinical activity of MRTX849 to recommend Phase 2 regimens |
|
| Phase 2 | Experimental | Separate cohorts of patients stratified by histological diagnosis, prior treatment history or co-mutation status (e.g., STK11) for evaluation of clinical activity of MRTX849 |
|
| Pilot Phase 1b Combination with Pembrolizumab | Experimental | Phase 1 evaluation of the safety, tolerability, PK and clinical activity of MRTX849 in combination with pembrolizumab in patients with NSCLC |
|
| Pilot Phase 1b Combination with Cetuximab | Experimental | Phase 1 evaluation of the safety, tolerability, PK and clinical activity of MRTX849 in combination with cetuximab in patients with CRC |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRTX849 | Drug | MRTX849 will be administered orally once or twice daily in a continuous regimen |
|
| Measure | Description | Time Frame |
|---|---|---|
| Characterize the safety of MRTX849 in patients having advanced solid tumor malignancies with KRAS G12C mutation | Number of participants with treatment related adverse events | 20 months |
| Evaluate the pharmacokinetics of MRTX849 | Blood plasma concentration | 20 months |
| Evaluate clinical activity/efficacy of MRTX849 | Objective response rate in accordance with Response Evaluation Criteria in Solid Tumors (RECIST) | 20 months |
| Measure | Description | Time Frame |
|---|---|---|
| Establish maximum tolerated dose | Number of participants with dose limiting toxicity | 12 months |
| Characterize safety and tolerability of MRTX849 in combination with selected therapeutic agents |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bristol-Myers Squibb | Bristol-Myers Squibb | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Local Institution - 001-826 | Birmingham | Alabama | 35294 | United States | ||
| Local Institution - 001-965 |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37327468 | Derived | Negrao MV, Spira AI, Heist RS, Janne PA, Pacheco JM, Weiss J, Gadgeel SM, Velastegui K, Yang W, Der-Torossian H, Christensen JG, Sabari JK. Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With KRASG12C-Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases. J Clin Oncol. 2023 Oct 1;41(28):4472-4477. doi: 10.1200/JCO.23.00046. Epub 2023 Jun 16. | |
| 37099736 |
| Label | URL |
|---|---|
| BMS Clinical Trial Information | View source |
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| Pilot Phase 1b Combination with Afatinib | Experimental | Phase 1 evaluation of the safety, tolerability, PK and clinical activity of MRTX849 in combination with afatinib in patients with NSCLC |
|
| Phase 2 Combination with Cetuximab | Experimental | Phase 2 evaluation of the clinical activity of MRTX849 in combination with cetuximab in patients with CRC |
|
| Pilot Phase 1b Combination with Cetuximab in NSCLC | Experimental | Phase 1 evaluation of the safety, tolerability, PK and clinical activity of MRTX849 in combination with cetuximab in patients with NSCLC |
|
| Pilot Phase 1b Combination with Cetuximab in PDAC | Experimental | Phase 1 evaluation of the safety, tolerability, PK and clinical activity of MRTX849 in combination with cetuximab in patients with pancreatic adenocarcinoma (PDAC) |
|
| Pembrolizumab | Drug | Pembrolizumab is administered as an intravenous infusion once every 3 weeks |
|
| Cetuximab | Drug | Cetuximab will be administered as an intravenous infusion once per week or once every 2 weeks |
|
| Afatinib | Drug | Afatinib will be administered orally once a day in a continuous regimen |
|
Number of participants with dose limiting toxicity
| 12 months |
| Evaluate the pharmacokinetics of new MRTX849 oral formulations | Blood plasma concentration | 6 months |
| Evaluate the pharmacokinetics of MRTX849 administered with food | Blood plasma concentration | 6 months |
| Anchorage |
| Alaska |
| 99508 |
| United States |
| Local Institution - 001-821 | Phoenix | Arizona | 85054 | United States |
| Local Institution - 001-873-A | Tucson | Arizona | 85704 | United States |
| Local Institution - 001-873 | Tucson | Arizona | 85704 | United States |
| Local Institution - 001-840-B | Bellflower | California | 90706 | United States |
| Local Institution - 001-834 | Beverly Hills | California | 90211 | United States |
| Local Institution - 001-843 | Duarte | California | 91010 | United States |
| Local Institution - 001-850-K | Dublin | California | 94568 | United States |
| Local Institution - 001-851 | Fullerton | California | 92835 | United States |
| Local Institution - 001-840-C | Harbor City | California | 90710 | United States |
| Local Institution - 001-805 | La Jolla | California | 92093 | United States |
| Local Institution - 001-779 | Los Alamitos | California | 90720 | United States |
| Local Institution - 001-840 | Los Angeles | California | 90027 | United States |
| Local Institution - 001-578 | Los Angeles | California | 90067 | United States |
| Local Institution - 001-847 | Newport Beach | California | 92663 | United States |
| Local Institution - 001-850-B | Oakland | California | 94611 | United States |
| Local Institution - 001-803 | Orange | California | 92868 | United States |
| Local Institution - 001-850-C | Roseville | California | 95661 | United States |
| Local Institution - 001-850-J | Sacramento | California | 95814 | United States |
| Local Institution - 001-850-D | Sacramento | California | 95825 | United States |
| Local Institution - 001-845 | San Diego | California | 92111 | United States |
| Local Institution - 001-840-A | San Diego | California | 92120 | United States |
| Local Institution - 001-850-H | San Francisco | California | 94080 | United States |
| Local Institution - 001-850-E | San Francisco | California | 94115 | United States |
| Local Institution - 001-850-F | San Jose | California | 95119 | United States |
| Local Institution - 001-850-A | San Leandro | California | 94577 | United States |
| Local Institution - 001-884 | Santa Barbara | California | 93105 | United States |
| Local Institution - 001-850-I | Santa Clara | California | 95051 | United States |
| Local Institution - 001-884-A | Solvang | California | 93463 | United States |
| Local Institution - 001-850 | Vallejo | California | 94589 | United States |
| Local Institution - 001-850-G | Walnut Creek | California | 94596 | United States |
| Local Institution - 001-872 | Aurora | Colorado | 80012 | United States |
| Local Institution - 001-810 | Aurora | Colorado | 80045 | United States |
| Local Institution - 001-872-H | Boulder | Colorado | 80303 | United States |
| Local Institution - 001-872-E | Colorado Springs | Colorado | 80907 | United States |
| Local Institution - 001-872-L | Colorado Springs | Colorado | 80920 | United States |
| Local Institution - 001-872-B | Denver | Colorado | 80218 | United States |
| Local Institution - 001-951 - A | Denver | Colorado | 80218 | United States |
| Local Institution - 001-951 - B | Denver | Colorado | 80218 | United States |
| Local Institution - 001-846 | Grand Junction | Colorado | 81501 | United States |
| Local Institution - 001-951 | Lafayette | Colorado | 80026 | United States |
| Local Institution - 001-872-A | Lakewood | Colorado | 80228 | United States |
| Local Institution - 001-872-D | Littleton | Colorado | 80218 | United States |
| Local Institution - 001-872-K | Lone Tree | Colorado | 80124 | United States |
| Local Institution - 001-872-C | Longmont | Colorado | 80501 | United States |
| Local Institution - 001-872-J | Parker | Colorado | 80138 | United States |
| Local Institution - 001-872-F | Pueblo | Colorado | 81008 | United States |
| Local Institution - 001-872-G | Pueblo | Colorado | 81008 | United States |
| Local Institution - 001-872-I | Thornton | Colorado | 80260 | United States |
| Local Institution - 001-816 | New Haven | Connecticut | 06510 | United States |
| Local Institution - 001-871 | Newark | Delaware | 19713-2055 | United States |
| Local Institution - 001-929i | Altamonte Springs | Florida | 32701 | United States |
| Local Institution - 001-839 | Boca Raton | Florida | 33432 | United States |
| Local Institution - 001-922A | Bonita Springs | Florida | 34135 | United States |
| Local Institution - 001-922D | Bradenton | Florida | 34211 | United States |
| Local Institution - 001-929c | Brandon | Florida | 33511 | United States |
| Local Institution - 001-922E | Cape Coral | Florida | 33909 | United States |
| Local Institution - 001-929g | Clearwater | Florida | 33761 | United States |
| Local Institution - 001-926b | Daytona Beach | Florida | 32117 | United States |
| Local Institution - 001-922 | Fort Myers | Florida | 33901 | United States |
| Local Institution - 001-922B | Fort Myers | Florida | 33905 | United States |
| Local Institution - 001-922C | Fort Myers | Florida | 33908 | United States |
| Local Institution - 001-929b | Gainesville | Florida | 32605 | United States |
| Local Institution - 001-829 | Jacksonville | Florida | 32224 | United States |
| Local Institution - 001-929m | Lady Lake | Florida | 32159 | United States |
| Local Institution - 001-929e | Largo | Florida | 33770 | United States |
| Local Institution - 001-929n | Lecanto | Florida | 34461 | United States |
| Local Institution - 001-870 | Miami | Florida | 33176 | United States |
| Local Institution - 001-825 | Miami Beach | Florida | 33140 | United States |
| Local Institution - 001-922F | Naples | Florida | 34102 | United States |
| Local Institution - 001-922G | Naples | Florida | 34102 | United States |
| Local Institution - 001-538 | Ocala | Florida | 34474 | United States |
| Local Institution - 001-929p | Ocala | Florida | 34474 | United States |
| Local Institution - 001-914 | Orange City | Florida | 32763 | United States |
| Local Institution - 001-929j | Orange City | Florida | 32763 | United States |
| Local Institution - 001-929l | Orlando | Florida | 32806 | United States |
| Local Institution - 001-877 | Pensacola | Florida | 32503 | United States |
| Local Institution - 001-922H | Port Charlotte | Florida | 33980 | United States |
| Local Institution - 001-922I | Sarasota | Florida | 34232 | United States |
| Local Institution - 001-922J | Sarasota | Florida | 34236 | United States |
| Local Institution - 001-929h | Spring Hill | Florida | 34608 | United States |
| Local Institution - 001-929a | St. Petersburg | Florida | 33705 | United States |
| Local Institution - 001-929 | St. Petersburg | Florida | 33705 | United States |
| Local Institution - 001-926d | Stuart | Florida | 34994 | United States |
| Local Institution - 001-929d | Tampa | Florida | 33607 | United States |
| Local Institution - 001-929k | Tavares | Florida | 32778 | United States |
| Local Institution - 001-929f | Trinity | Florida | 34655 | United States |
| Local Institution - 001-922K | Venice | Florida | 34285 | United States |
| Local Institution - 001-922L | Venice | Florida | 34292 | United States |
| Local Institution - 001-926c | Vero Beach | Florida | 32960 | United States |
| Local Institution - 001-926a | Wellington | Florida | 33414 | United States |
| Local Institution - 001-926 | West Palm Beach | Florida | 33401 | United States |
| Local Institution - 001-929o | Winter Park | Florida | 32789 | United States |
| Local Institution - 001-967 | Athens | Georgia | 30607 | United States |
| Local Institution - 001-835-C | Austell | Georgia | 30106 | United States |
| Local Institution - 001-835-E | Austell | Georgia | 30106 | United States |
| Local Institution - 001-835-D | Carrollton | Georgia | 30117 | United States |
| Local Institution - 001-835-F | Carrollton | Georgia | 30117 | United States |
| Local Institution - 001-835-A | Cartersville | Georgia | 30121 | United States |
| Local Institution - 001-835-B | Douglasville | Georgia | 30134 | United States |
| Local Institution - 001-835 | Marietta | Georgia | 30060 | United States |
| Local Institution - 001-862 | Chicago Ridge | Illinois | 60415 | United States |
| Local Institution - 001-883 | Niles | Illinois | 60714 | United States |
| Local Institution - 001-781 | South Bend | Indiana | 46601 | United States |
| Local Institution - 001-831 | Iowa City | Iowa | 52242 | United States |
| Local Institution - 001-820 | Westwood | Kansas | 66205 | United States |
| Local Institution - 001-844 | Lexington | Kentucky | 40536 | United States |
| Local Institution - 001-920 | Baton Rouge | Louisiana | 70809 | United States |
| Local Institution - 001-827 | Biddeford | Maine | 04005 | United States |
| Local Institution - 001-881-B | Brandywine | Maryland | 20613 | United States |
| Local Institution - 001-881 | Columbia | Maryland | 21044 | United States |
| Local Institution - 001-881-A | Silver Spring | Maryland | 20904 | United States |
| Local Institution - 001-808 | Boston | Massachusetts | 02215 | United States |
| Local Institution - 001-842 | Detroit | Michigan | 48201 | United States |
| Local Institution - 001-811 | Detroit | Michigan | 48202 | United States |
| Local Institution - 001-842-A | Farmington Hills | Michigan | 48334 | United States |
| Local Institution - 001-838-F | Coon Rapids | Minnesota | 55433 | United States |
| Local Institution - 001-838-E | Edina | Minnesota | 55435 | United States |
| Local Institution - 001-875 - D | Edina | Minnesota | 55435 | United States |
| Local Institution - 001-838-D | Maplewood | Minnesota | 55109 | United States |
| Local Institution - 001-875 - A | Maplewood | Minnesota | 55109 | United States |
| Local Institution - 001-838-C | Minneapolis | Minnesota | 55404 | United States |
| Local Institution - 001-875 | Minneapolis | Minnesota | 55404 | United States |
| Local Institution - 001-838-G | Minneapolis | Minnesota | 55415 | United States |
| Local Institution - 001-822-A | Minneapolis | Minnesota | 55455 | United States |
| Local Institution - 001-822 | Minneapolis | Minnesota | 55455 | United States |
| Local Institution - 001-830 | Rochester | Minnesota | 55905 | United States |
| Local Institution - 001-838 | Saint Louis Park | Minnesota | 55416 | United States |
| Local Institution - 001-838-B | Saint Louis Park | Minnesota | 55426-5000 | United States |
| Local Institution - 001-838-A | Saint Paul | Minnesota | 55101 | United States |
| Local Institution - 001-875 - B | Saint Paul | Minnesota | 55102 | United States |
| Local Institution - 001-875 - C | Woodbury | Minnesota | 55125 | United States |
| Local Institution - 001-952 | Bolivar | Missouri | 65613 | United States |
| Local Institution - 001-950 | Jefferson City | Missouri | 65109 | United States |
| Local Institution - 001-841 | Billings | Montana | 59102 | United States |
| Local Institution - 001-544B | Omaha | Nebraska | 68105-1850 | United States |
| Local Institution - 001-959 | Omaha | Nebraska | 68114 | United States |
| Local Institution - 001-544A | Omaha | Nebraska | 68118 | United States |
| Local Institution - 001-544 | Omaha | Nebraska | 68198 | United States |
| Local Institution - 001-860A | Henderson | Nevada | 89052 | United States |
| Local Institution - 001-860C | Henderson | Nevada | 89052 | United States |
| Local Institution - 001-860B | Henderson | Nevada | 89074 | United States |
| Local Institution - 001-860 | Henderson | Nevada | 89074 | United States |
| Local Institution - 001-860E | Las Vegas | Nevada | 89128 | United States |
| Local Institution - 001-860D | Las Vegas | Nevada | 89144 | United States |
| Local Institution - 001-860F | Las Vegas | Nevada | 89148 | United States |
| Local Institution - 001-861 | Albany | New York | 12206 | United States |
| Local Institution - 001-815 | Buffalo | New York | 14203 | United States |
| Local Institution - 001-813 | New York | New York | 10016 | United States |
| Local Institution - 001-806 | New York | New York | 10065 | United States |
| Local Institution - 001-812 | Chapel Hill | North Carolina | 27514 | United States |
| Local Institution - 001-971 | Pinehurst | North Carolina | 28374 | United States |
| Local Institution - 001-966 | Cincinnati | Ohio | 45219 | United States |
| Local Institution - 001-823 | Cincinnati | Ohio | 45267 | United States |
| Local Institution - 001-818 | Cleveland | Ohio | 44195 | United States |
| Local Institution - 001-833 - H | Columbus | Ohio | 43201 | United States |
| Local Institution - 001-833 - C | Columbus | Ohio | 43203 | United States |
| Local Institution - 001-833 - J | Columbus | Ohio | 43203 | United States |
| Local Institution - 001-833 - A | Columbus | Ohio | 43210 | United States |
| Local Institution - 001-833 - F | Columbus | Ohio | 43210 | United States |
| Local Institution - 001-833 | Columbus | Ohio | 43210 | United States |
| Local Institution - 001-833 - D | Columbus | Ohio | 43212 | United States |
| Local Institution - 001-833 - I | Columbus | Ohio | 43212 | United States |
| Local Institution - 001-930 | Columbus | Ohio | 43219 | United States |
| Local Institution - 001-833 - B | Columbus | Ohio | 43221 | United States |
| Local Institution - 001-833 - G | Columbus | Ohio | 43221 | United States |
| Local Institution - 001-833 - E | Gahanna | Ohio | 43230 | United States |
| Local Institution - 001-836-A | Kettering | Ohio | 45429 | United States |
| Local Institution - 001-836 | Kettering | Ohio | 45429 | United States |
| Local Institution - 001-600 | Lawton | Oklahoma | 73505 | United States |
| Local Institution - 001-584 | Tulsa | Oklahoma | 74146 | United States |
| Local Institution - 001-586-A | Bend | Oregon | 97701 | United States |
| Local Institution - 001-586 | Bend | Oregon | 97701 | United States |
| Local Institution - 001-889 | Eugene | Oregon | 97401 | United States |
| Local Institution - 001-837 | Allentown | Pennsylvania | 18103 | United States |
| Local Institution - 001-837-A | Bethlehem | Pennsylvania | 18017 | United States |
| Local Institution - 001-817 | Hershey | Pennsylvania | 17033-0850 | United States |
| Local Institution - 001-783 | Media | Pennsylvania | 19063 | United States |
| Local Institution - 001-887 | Charleston | South Carolina | 29414 | United States |
| Local Institution - 001-819 | Charleston | South Carolina | 29425 | United States |
| Local Institution - 001-801-G | Gallatin | Tennessee | 37066 | United States |
| Local Institution - 001-801-A | Hendersonville | Tennessee | 37075 | United States |
| Local Institution - 001-801-D | Hermitage | Tennessee | 37076 | United States |
| Local Institution - 001-801-F | Murfreesboro | Tennessee | 37129 | United States |
| Local Institution - 001-801-B | Nashville | Tennessee | 37203 | United States |
| Local Institution - 001-801 | Nashville | Tennessee | 37203 | United States |
| Local Institution - 001-801-E | Nashville | Tennessee | 37207 | United States |
| Local Institution - 001-801-C | Nashville | Tennessee | 37211 | United States |
| Local Institution - 001-888-B | Arlington | Texas | 76012 | United States |
| Local Institution - 001-888 | Arlington | Texas | 76012 | United States |
| Local Institution - 001-880 | Austin | Texas | 78731 | United States |
| Local Institution - 001-848a | Conroe | Texas | 77384 | United States |
| Local Institution - 001-809 | Dallas | Texas | 75230 | United States |
| Local Institution - 001-886 | Dallas | Texas | 75231 | United States |
| Local Institution - 001-879 | Dallas | Texas | 75246 | United States |
| Local Institution - 001-785 | Denison | Texas | 75020 | United States |
| Local Institution - 001-876 | Fort Worth | Texas | 76104 | United States |
| Local Institution - 001-848 | Houston | Texas | 77030 | United States |
| Local Institution - 001-969 | Houston | Texas | 77030 | United States |
| Local Institution - 001-935A | Houston | Texas | 77090 | United States |
| Local Institution - 001-999 | Irving | Texas | 75063 | United States |
| Local Institution - 001-935D | Kingwood | Texas | 77339 | United States |
| Local Institution - 001-935 | Kingwood | Texas | 77339 | United States |
| Local Institution - 001-554 | Midland | Texas | 79701 | United States |
| Local Institution - 001-802 | San Antonio | Texas | 78229 | United States |
| Local Institution - 001-935B | Shenandoah | Texas | 77380 | United States |
| Local Institution - 001-935C | Spring | Texas | 77389 | United States |
| Local Institution - 001-874 | Sugar Land | Texas | 77479 | United States |
| Local Institution - 001-935E | Tomball | Texas | 77375 | United States |
| Local Institution - 001-878 | Tyler | Texas | 75702 | United States |
| Local Institution - 001-890 | Waco | Texas | 76712 | United States |
| Local Institution - 001-814 | Fairfax | Virginia | 22031 | United States |
| Local Institution - 001-597 | Fredericksburg | Virginia | 24408 | United States |
| Local Institution - 001-882 | Newport News | Virginia | 23606 | United States |
| Local Institution - 001-882-A | Norfolk | Virginia | 23502 | United States |
| Local Institution - 001-890-A | Norfolk | Virginia | 23502 | United States |
| Local Institution - 001-968 | Richmond | Virginia | 23229 | United States |
| Local Institution - 001-824 | Seattle | Washington | 98109 | United States |
| Local Institution - 001-885 | Vancouver | Washington | 98684 | United States |
| Local Institution - 001-804 | Madison | Wisconsin | 53792 | United States |
| Local Institution - 001-900 | San Juan | PR | 00935 | Puerto Rico |
| Derived |
| Bekaii-Saab TS, Yaeger R, Spira AI, Pelster MS, Sabari JK, Hafez N, Barve M, Velastegui K, Yan X, Shetty A, Der-Torossian H, Pant S. Adagrasib in Advanced Solid Tumors Harboring a KRASG12C Mutation. J Clin Oncol. 2023 Sep 1;41(25):4097-4106. doi: 10.1200/JCO.23.00434. Epub 2023 Apr 26. |
| 36546659 | Derived | Yaeger R, Weiss J, Pelster MS, Spira AI, Barve M, Ou SI, Leal TA, Bekaii-Saab TS, Paweletz CP, Heavey GA, Christensen JG, Velastegui K, Kheoh T, Der-Torossian H, Klempner SJ. Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C. N Engl J Med. 2023 Jan 5;388(1):44-54. doi: 10.1056/NEJMoa2212419. Epub 2022 Dec 21. |
| 35658005 | Derived | Janne PA, Riely GJ, Gadgeel SM, Heist RS, Ou SI, Pacheco JM, Johnson ML, Sabari JK, Leventakos K, Yau E, Bazhenova L, Negrao MV, Pennell NA, Zhang J, Anderes K, Der-Torossian H, Kheoh T, Velastegui K, Yan X, Christensen JG, Chao RC, Spira AI. Adagrasib in Non-Small-Cell Lung Cancer Harboring a KRASG12C Mutation. N Engl J Med. 2022 Jul 14;387(2):120-131. doi: 10.1056/NEJMoa2204619. Epub 2022 Jun 3. |
| 35404402 | Derived | Sabari JK, Velcheti V, Shimizu K, Strickland MR, Heist RS, Singh M, Nayyar N, Giobbie-Hurder A, Digumarthy SR, Gainor JF, Rajan AP, Nieblas-Bedolla E, Burns AC, Hallin J, Olson P, Christensen JG, Kurz SC, Brastianos PK, Wakimoto H. Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer. Clin Cancer Res. 2022 Aug 2;28(15):3318-3328. doi: 10.1158/1078-0432.CCR-22-0383. |
| 35167329 | Derived | Ou SI, Janne PA, Leal TA, Rybkin II, Sabari JK, Barve MA, Bazhenova L, Johnson ML, Velastegui KL, Cilliers C, Christensen JG, Yan X, Chao RC, Papadopoulos KP. First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With Advanced KRASG12C Solid Tumors (KRYSTAL-1). J Clin Oncol. 2022 Aug 10;40(23):2530-2538. doi: 10.1200/JCO.21.02752. Epub 2022 Feb 15. |
| 34161704 | Derived | Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, Feng H, Zhang SS, Haigis KM, Hung YP, Sholl LM, Wolpin BM, Wiese J, Christiansen J, Lee J, Schrock AB, Lim LP, Garg K, Li M, Engstrom LD, Waters L, Lawson JD, Olson P, Lito P, Ou SI, Christensen JG, Janne PA, Aguirre AJ. Acquired Resistance to KRASG12C Inhibition in Cancer. N Engl J Med. 2021 Jun 24;384(25):2382-2393. doi: 10.1056/NEJMoa2105281. |
| BMS Clinical Trial Patient Recruiting | View source |
| ID | Term |
|---|---|
| D009362 | Neoplasm Metastasis |
| D009369 | Neoplasms |
| D015179 | Colorectal Neoplasms |
| D003110 | Colonic Neoplasms |
| D010190 | Pancreatic Neoplasms |
| ID | Term |
|---|---|
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| C000718190 | adagrasib |
| C582435 | pembrolizumab |
| D000068818 | Cetuximab |
| D000077716 | Afatinib |
| ID | Term |
|---|---|
| D061067 | Antibodies, Monoclonal, Humanized |
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D011799 | Quinazolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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