Patients with acute renal colic divided into 2 groups. Group L administered ornoxicam and Group P administered pethidine and VAS was recorded for both groups.

Prospective, randomized, double blind clinical study including 120 patients with acute renal pain admitted in emergency department. They were randomly assigned to one of two groups using a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg-1 ketamine and Group P received pethidine 50 mg IV. Parameters were observed at baseline and after 0, 15, 30, 45 and 1 hour of drug treatment. The efficacy of the drug was measured by observing: patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue analgesia, adverse events and functional status.

Inclusion Criteria:

• Patients, who did not administer any analgesics at least within the last two hours. - -
• Patients aged between 20-60 years.

Exclusion Criteria:

• Patients with previous renal surgery
• liver and renal failure
• hypersensitivity to lornoxicam, ketamine and pethidine, history of peptic ulcer,
• gastrointestinal bleeding and perforation,
• hypertensive and history of cardiac diseases
• pregnancy and lactation and
• urine examination showing more than 5 leukocytes suggestive of pyuria.
• patients with hyperthyroidism are excluded