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Strabismus surgery for children is a very common procedure, with a high incidence of emergence delirium in the recovery room. Pain is often implicated in delirium. The primary aim of this study is to determine whether a single, intraoperative dose of methadone for outpatient ambulatory pediatric strabismus surgery reduces postoperative delirium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study | pediatric patients undergoing outpatient strabismus surgery, and receiving methadone |
| |
| control | pediatric patients undergoing outpatient strabismus surgery, and not receiving methadone |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methadone | Drug | see desc above |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pediatric Anesthesia Emergence Delirium scale scores | A low total score would indicate less emergence delirium | measured every 10 minutes in the recovery room, until patient is discharged, up to 6 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| wong-baker or numeric pain scores, depending on age | A low total score would indicate less pain | measured every 10 minutes in the recovery room, until patient is discharged, up to 6 hours. |
| discharge time |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy children, aged 0-18 years, undergoing outpatient strabismus surgery under general anesthesia
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ochsner Main Campus | Jefferson | Louisiana | 70121 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29847382 | Background | Komen H, Brunt LM, Deych E, Blood J, Kharasch ED. Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study. Anesth Analg. 2019 Apr;128(4):802-810. doi: 10.1213/ANE.0000000000003464. | |
| 24666686 | Background | Ward RM, Drover DR, Hammer GB, Stemland CJ, Kern S, Tristani-Firouzi M, Lugo RA, Satterfield K, Anderson BJ. The pharmacokinetics of methadone and its metabolites in neonates, infants, and children. Paediatr Anaesth. 2014 Jun;24(6):591-601. doi: 10.1111/pan.12385. Epub 2014 Mar 26. |
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| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| D013285 | Strabismus |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D008691 | Methadone |
| ID | Term |
|---|---|
| D007659 | Ketones |
| D009930 | Organic Chemicals |
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time the patient is actually discharged from recovery room
| 24 hours |
| D009422 |
| Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D015835 | Ocular Motility Disorders |
| D003389 | Cranial Nerve Diseases |
| D005128 | Eye Diseases |