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| ID | Type | Description | Link |
|---|---|---|---|
| 2018-A00423-52 | Other Identifier | ID-RCB number, ANSM |
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Muscle and physical activity play an important role in in growth, development and bone health in healthy children, especially during puberty. Children with inflammatory bowel disease (IBD) have lower level and intensity of physical compared to a control group. Several studies have shown that children with IBD have a lower bone mineral density (BMD) than general population, due to risk factors such as corticosteroid use, disease intensity, inflammation, malnutrition and a vitamin D deficiency. This low BMD is associated with an increased risk of fracture. A recent observational study found a positive and significant correlation between BMD in IBD patients and time spent in moderate to vigorous physical activity for one week (unpublished data).The present study aims to show a benefit of an adapted physical activity program on BMD in children and adolescents with IBD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| physical activity program | Experimental | Child with an adapted physical activity program |
|
| Usual care | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Usual care | Other | Patients included in the control group will not benefit from the intervention in adapted physical activity. However, this will not affect their support. Patients will be seen by their specialist doctor as part of the usual management of their IBD. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in total (whole body) Bone Mineral Density | At 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in vertebral BMD | At 9 months | |
| Change in femoral body BMD | At 9 months | |
| Change in time spent (minutes / day) in moderate to vigorous physical activity measured by accelerometry for 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stéphanie COOPMAN, MD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Amiens Picardie | Amiens | France | ||||
| Hop Jeanne de Flandre Chu Lille |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32430452 | Result | Vanhelst J, Coopman S, Labreuche J, Dupont C, Bertrand V, Djeddi D, Turck D, Ley D. Protocol of a randomised controlled trial assessing the impact of physical activity on bone health in children with inflammatory bowel disease. BMJ Open. 2020 May 18;10(5):e036400. doi: 10.1136/bmjopen-2019-036400. |
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| adapted physical activity | Other | Patients in the experimental group will have, in addition to their usual follow-up with their specialist doctor, an intervention in adapted physical activity at home, at the rate of 3 sessions (of a duration of 10 to 20 minutes) per week during 9 consecutive months. |
|
| At 9 months |
| Change in in fat mass measured by two-photon absorptiometry (%) | At 9 months |
| Change in lean mass measured by two-photon absorptiometry (kg) | At 9 months |
| Change IMPACT score III | related quality of life instrument in children with inflammatory bowel disease. | At 9 months |
| Change in pediatrics crohn's disease activity index or pediatric ulcerative colitis activity index | At 9 months |
| Change in biologic inflammatory parameters by decrease or increase C-reactive protein | At 9 months |
| Lille |
| France |
| ID | Term |
|---|---|
| D003424 | Crohn Disease |
| D003093 | Colitis, Ulcerative |
| D000092122 | Bronchiolitis Obliterans Syndrome |
| D003092 | Colitis |
| D015212 | Inflammatory Bowel Diseases |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
| D003108 | Colonic Diseases |
| D000092124 | Organizing Pneumonia |
| D001989 | Bronchiolitis Obliterans |
| D001988 | Bronchiolitis |
| D001991 | Bronchitis |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D006086 | Graft vs Host Disease |
| D007154 | Immune System Diseases |
| D001519 | Behavior |
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