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| Name | Class |
|---|---|
| Ann & Robert H Lurie Children's Hospital of Chicago | OTHER |
| Northwestern University | OTHER |
| University of Illinois at Chicago | OTHER |
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The objective of this study is to develop an automated, precise, quantitative assay for detecting atypical motor behavior and development in infants using data from wearable sensors and video recordings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infants at Risk for Atypical Motor Development (high-risk) | |||
| Infants Expected to Have Typical Motor Development (low-risk) |
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| Measure | Description | Time Frame |
|---|---|---|
| Three month clinical score estimation | Error between true clinical test scores and scores estimated from sensor and video data, assessed at the 3 month time-point. | 3 months |
| Six month clinical score estimation | Error between true clinical test scores and scores estimated from sensor and video data, assessed at 6 month time-point. | 6 months |
| Prediction of neuromotor outcome using sensor and video data from 3 month time-point | Sensitivity and specificity of algorithm (trained on sensor and video data from the 3 month time-point) to predict neuromotor outcome at final study visit (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]) | 3 months |
| Prediction of neuromotor outcome using sensor and video data from 6 month time-point | Sensitivity and specificity of algorithm (trained on sensor and video data from the 6 month time-point) to predict neuromotor outcome at final study visit (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Prediction of neuromotor outcome using General Movements Assessment (GMA) scores | Sensitivity and specificity of GMA scores (taken at 1-2 weeks, 1 month, 3 months) to predict neuromotor outcome at final study visit (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]). The GMA is an observational exam where an infant's spontaneous movements are scored as atypical or normal for their age. |
| Measure | Description | Time Frame |
|---|---|---|
| Prediction of neuromotor outcome using NICU Network Neurobehavioral Scale (NNNS) scores | Sensitivity and specificity of NNNS scores (taken at 1 month) to predict neuromotor outcome at final study visit (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]) | 1 month |
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Exclusion Criteria:
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Individuals at high risk of developing motor delays <24 months of age along with infants at low risk of developing motor delays.
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| Name | Affiliation | Role |
|---|---|---|
| Arun Jayaraman, PT, PhD | Shirley Ryan AbilityLab | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shirley Ryan AbilityLab | Chicago | Illinois | 60611 | United States | ||
| University of Illinois at Chicago |
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| ID | Term |
|---|---|
| D011596 | Psychomotor Disorders |
| D065886 | Neurodevelopmental Disorders |
| D002658 | Developmental Disabilities |
| ID | Term |
|---|---|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| 1-2 weeks, 1 month, 3 months |
| Prediction of neuromotor outcome using Alberta Infant Motor Scale (AIMS) scores | Sensitivity and specificity of AIMS scores (taken at 6 months, 9 months, 1 year) to predict neuromotor outcome at final study visit (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]). The AIMS is a norm-referenced observational assessment with a minimum score of 0 and a maximum score of 58. Higher scores indicate better motor performance on the assessment. | 6 months, 9 months, 1 year |
| Prediction of neuromotor outcome using Hammersmith Infant Neurological Examination (HINE) scores | Sensitivity and specificity of HINE scores (taken at 6 months, 9 months, 1 year) to predict neuromotor outcome at final study visit (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]). The HINE is a neurological exam with a minimum score of 0 and a maximum score of 78. Higher scores indicate better performance on the assessment. | 6 months, 9 months, 1 year |
| Prediction of neuromotor outcome using Test of Infant Motor Performance (TIMP) scores | Sensitivity and specificity of TIMP scores (taken at 1-2 weeks, 1 month, 3 months) to predict neuromotor outcome at final study visit (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]). | 1-2 weeks, 1 month, 3 months |
| Clinical score estimation | Error between true clinical test scores and scores estimated from sensor and video data, assessed at each remaining time-point. | 1-2 weeks, 1 month, 9 months, 1 year, 2 years |
| Prediction of neuromotor outcome at 2 years using sensor and video data from the remaining time-points | Sensitivity and specificity of algorithm (trained on sensor and video data from the remaining time-points) to predict neuromotor outcome at 2 years (as measured by the Peabody Developmental Motor Scales, second edition [PDMS-2]) | 1-2 weeks, 1 month, 9 months, 1 year, 2 years |
| Chicago |
| Illinois |
| 60612 |
| United States |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |