Molecular Genetic, Host-derived and Clinical Determinants of Long-term Survival in Glioblastoma

Molecular Genetic, Host-derived and Clinical Determinants of Long-term Survival in Glioblastoma

This pro - and retrospective multicenter clinical epidemiological study studies the molecular genetic, host-derived and clinical determinants of glioblastoma patients with an overall survival of more than 5 years. The different research focusses are:

• Identification of clinical parameters and patient characteristics / host-related factors in long-term survivors (Focus 1)
• Identification of molecular tumor characteristics in long-term survivors (Focus 2)
• Assessment of therapy-related parameters, including neuro-toxicity (Focus 3)
• Immunological studies (Focus 4)

Inclusion Criteria:

• Age > 18 years at diagnosis
• Histopathological diagnosis of glioblastoma (reference histology available) and
• Survival >5 years from diagnosis
• Availability of tumor tissue from initial glioblastoma diagnosis (FFPE or fresh-frozen) to validate the diagnosis centrally.
• Signed consent form (living patients) or ethics approval for anonymous data collection in case of retrospective analysis of deceased patients

Exclusion Criteria:

• Not applicable