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| ID | Type | Description | Link |
|---|---|---|---|
| R01DC016275-01A1 | U.S. NIH Grant/Contract | View source | |
| OCR19032 | Other Identifier | UF ID | |
| 5R01DC016275-02 | U.S. NIH Grant/Contract | View source |
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IRB Closure
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| Name | Class |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
| National Institutes of Health (NIH) | NIH |
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This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6. The findings from this proposal will be the first step toward implementing rehabilitation techniques that help patients to prevent speech and swallowing errors before they occur.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stroke without Dysarthria | Experimental | Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
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| Stroke with Dysarthria | Experimental | Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
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| SCA6 without Dysarthria | Experimental | Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
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| SCA6 with Dysarthria | Experimental | Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intermittent Perturbation to Continuous Perturbation | Device | Manipulate the Movement Planning Period (MPP), by interrupting sensory predictions by removing e-stim during the inter-trial interval (Intermittent Perturbation), followed by a washout/de-adaptation period. |
| Measure | Description | Time Frame |
|---|---|---|
| Laryngeal Adaptation in Speech | To differentiate laryngeal adaptation during speech among cerebral stroke, SCA6, and healthy controls when vocal loudness is perturbed with expiratory loading. | Day 1 |
| Laryngeal Adaptation in Swallowing | To differentiate laryngeal adaptation among cerebral stroke, SCA6, and healthy controls when swallowing is perturbed with neck surface electrical stimulation to restrict laryngeal elevation. | Day 1 |
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Patient Inclusion Criteria:
All stroke and ataxia
Ataxia
Stroke
Stroke and ataxia with speech and swallowing disorders
Patient Exclusion Criteria:
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D020754 | Spinocerebellar Ataxias |
| D003680 | Deglutition Disorders |
| D004401 | Dysarthria |
| D013060 | Speech |
| D007818 | Laryngeal Diseases |
| D001259 | Ataxia |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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A cross-sectional study design will be used to examine laryngeal adaptation across all study groups.
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| Age-Matched Controls | Active Comparator | Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
|
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| Continuous Perturbation to Intermittent Perturbation | Device | Manipulate the Movement Planning Period (MPP), by keep sensory input about the perturbation constant by maintaining e-stim during the inter-trial interval. |
|
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D002524 | Cerebellar Ataxia |
| D002526 | Cerebellar Diseases |
| D013132 | Spinocerebellar Degenerations |
| D013118 | Spinal Cord Diseases |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D010608 | Pharyngeal Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D001184 | Articulation Disorders |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014705 | Verbal Behavior |
| D003142 | Communication |
| D001519 | Behavior |
| D012140 | Respiratory Tract Diseases |