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| Name | Class |
|---|---|
| National Psoriasis Foundation | OTHER |
| Icahn School of Medicine at Mount Sinai | OTHER |
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This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members. Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Psoriasis patients | Patients (of any age) who developed psoriasis before 12 years of age and who have no family history of psoriasis in either parent. |
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| Parents of psoriasis patients | Parents of patients who developed psoriasis before 12 years of age |
| |
| Up to third-degree family members with or without psoriasis | Up to third-degree family members (first cousin, grandparent, great-grandparent) with or without psoriasis, if family history is indicated. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Saliva or buccal sample | Other | Saliva or buccal sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| CARD14 mutations | The number of pathogenic mutations identified in CARD14 in a pediatric psoriasis cohort | one year |
| Measure | Description | Time Frame |
|---|---|---|
| De novo mutations | The number of candidate psoriasis genes through the identification of de novo mutations in moderate-to-severe pediatric cases who require systemic intervention. | one year |
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Inclusion Criteria:
Exclusion Criteria:
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This study will ascertain approximately 150 subjects, which will include pediatric psoriasis patients diagnosed before age 12, parents not affected by psoriasis, and if a family history is indicated, up to third-degree family members.
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| Name | Affiliation | Role |
|---|---|---|
| Amy Paller, MD | Northwestern University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611 | United States |
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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Saliva (or buccal swabs in the case of infants) will be obtained for DNA isolation.