The objective of this study was to investigate the association of irisin with inflammatory markers as well with metabolic and anthropometric parameters in children and adolescents with type 2 diabetes mellitus compared with healthy controls.

Mexican children and adolescents previously diagnosed with type 2 diabetes mellitus according to the American Diabetes Association (ADA) criteria were recruited and compared to healthy controls.

The participants will undergo:

• vital signs measurement (systolic and diastolic blood pressure, heart rate, respiratory rate)
• anthropometric variables measurement (BMI, weight, waist circumference, hip circumference, body fat %)
• laboratory studies: glucose, triglycerides, HDL-c, C reactive protein, irisin

After statistical analyses the investigators will compare the relationship of irisin and the inflammatory profile and the anthropometric parameters of diabetic patients versus lean controls.

Inclusion Criteria:

• Have been previously diagnosed with T2DM according to the American Diabetes Association (ADA) criteria .

Healthy controls were required to have:

• Normal weight according to the Centers for Disease Control and Prevention (CDC) criteria.
• No metabolic abnormalities on blood samples
• No previously diagnosed cardiometabolic diseases
• Not been using antihypertensive, lipid or glucose lowering medications

Exclusion Criteria:

• Disapproval by the children's physician due to any at-risk medical condition known by the parents
• Use of drugs for high blood pressure, hyperglycemia, or dyslipidemia

40 Mexican children and adolescents aged 7-17 (20 boys and 20 girls) 20 children and adolescents diagnosed with T2DM and 20 healthy controls