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Cannabis smokers who also smoke tobacco cigarettes have markedly higher rates of cannabis relapse relative to those who do not use tobacco. There is a clear need to develop and evaluate interventions for dual tobacco and cannabis users. The investigators of this study have previously shown that the co-use of tobacco cigarettes contributes to the maintenance of daily cannabis use, and that age of cigarette onset is a critical predictor of treatment outcome. Short-term tobacco cessation may suffice in altering cannabis relapse rates in later-onset cigarette smokers, while a longer period of tobacco cessation may be needed for earlier-onset smokers. In the current study, a human laboratory model will be utilized to determine whether cannabis relapse varies as a function of tobacco cessation duration and age of tobacco use onset.

Inclusion Criteria:

• Males and non-pregnant females aged 18-60 years old
• Use cannabis
• Smoke tobacco cigarettes
• Medically and psychologically healthy

Exclusion Criteria:

• Regular drug use other than cannabis
• Current pregnancy/lactation

Research staff will be blind to the age of tobacco onset condition.