Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell... | NCT03765918 | Trialant

Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell... | NCT03765918 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Has histologically confirmed new diagnosis of resectable, non-metastatic, squamous cell carcinoma that is either: Stage III Human Papillomavirus (HPV) positive oropharyngeal primary that is tumor size (T) 4, lymph node involvement (N) 0-2, no distant metastases (M0); Stage III or IVA oropharyngeal HPV negative; or Stage III or IVA larynx/hypopharynx/oral cavity primaries.

Is eligible for primary surgery based on investigator decision and per local practice

Female and male participants of reproductive potential must agree to use adequate contraception throughout the study period and for up to 180 days after the last dose of study therapy.

Male participants must refrain from donating sperm throughout the study period and for up to 180 days after the last dose of study therapy

Female participant that is not pregnant or breastfeeding

Has evaluable tumor burden (measurable and/or non-measurable tumor lesions) assessed by computed tomography (CT) scan or magnetic resonance imaging (MRI), based on Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1)

Has provided newly obtained core or excisional biopsy of a tumor lesion not previously irradiated

Has results from testing of HPV status for oropharyngeal cancer defined as p16

Has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 performed within 10 days of randomization

Exclusion Criteria:

Has Stage T4B and/or N3 locoregionally advanced head and neck squamous cell carcinoma (LA HNSCC) and/or distant metastases

Has cancer outside of the oropharynx, larynx, and hypopharynx or oral cavity. such as nasopharyngeal, sinus, other para-nasal, or other unknown primary head and neck cancer (HNC)

Female participant who has a positive urine pregnancy test within 72 hours prior to study start or within 24 hours prior to the start of radiotherapy with or without cisplatin.

Has received prior therapy with an anti-programmed cell death receptor 1 (PD-1), anti-programmed cell death receptor ligand 1(PD-L1), or anti-programmed cell death receptor ligand 2 (PD-L2) agent or with an agent directed to another co-inhibitory T-cell receptor

Has received prior radiotherapy treatment or systemic anti-cancer therapy including investigational agents for the HNC under study prior to study start

Has received a live vaccine within 30 days prior to randomization

Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to randomization

Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to randomization

Has a known additional malignancy that is progressing or has required active treatment within the past 3 years with the exception of basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g. in situ cervical cancer or breast carcinoma) that have undergone potentially curative therapy

Has radiographically detectable (even if asymptomatic and/or previously treated) central nervous system metastases and/or carcinomatous meningitis

Has Grade ≥2 audiometric hearing loss

Has Grade ≥2 neuropathy

Has Grade 3-4 bleeding due to the underlying malignancy

Has received major surgery or has not recovered adequately from the toxicity and/or complications from the intervention prior to study start

Has had previous allogeneic tissue/solid organ transplant

Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients, radiotherapy, cisplatin or their analogs

Has an active autoimmune disease that has required systemic treatment in past 2 years

Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis

Has an active infection requiring systemic therapy

Has a known history of human immunodeficiency virus (HIV) infection

Has a known history of or is positive for Hepatitis B (defined as hepatitis B surface antigen [HBsAg] reactive) or known active Hepatitis C (defined as Hepatitis C virus [HCV] ribonucleic acid is detected).

Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the participant's participation for the full duration of the study, or is not in the best interest of the participant to participate, in the opinion of the investigator

Has a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study

Moores Cancer Center ( Site 1885)

La Jolla, California 92093-0698, United States

University of Southern California Norris Comprehensive Cancer Center ( Site 1850)

Los Angeles, California 90033, United States

Hoag Memoriall Hospital Presbyterian ( Site 2056)

Newport Beach, California 92663, United States

UC Davis Health System ( Site 1864)

Sacramento, California 95817, United States

St. Joseph Heritage Healthcare ( Site 1806)

Santa Rosa, California 95403, United States

University of Colorado Cancer Center ( Site 1838)

Aurora, Colorado 80045, United States

MedStar Washington Hospital Center ( Site 2062)

Washington D.C., District of Columbia 20010, United States

George Washington University Medical Faculty Associates ( Site 2035)

Washington D.C., District of Columbia 20037, United States

University of Florida ( Site 1832)

Gainesville, Florida 32608, United States

University of Miami, Sylvester Comprehensive Cancer Center ( Site 2008)

Miami, Florida 33136, United States

AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlandoc ( Site 2054)

Orlando, Florida 32804, United States

Orlando Health Cancer Institute ( Site 2061)

Orlando, Florida 32806, United States

Saint Alphonsus Regional Medical Center ( Site 2021)

Boise, Idaho 83706, United States

Beacon Cancer Care ( Site 2052)

Post Falls, Idaho 83854, United States

Rush University Medical Center ( Site 1823)

Chicago, Illinois 60607, United States

NorthShore University HealthSystem ( Site 1812)

Evanston, Illinois 60201, United States

Loyola University Medical Center [Maywood, IL] ( Site 1817)

Maywood, Illinois 60153, United States

University of Kansas Cancer Center ( Site 2004)

Westwood, Kansas 66205, United States

University of Kentucky Chandler Medical Center-Medical Oncology ( Site 2069)

Lexington, Kentucky 40536, United States

Ochsner Cancer Institute ( Site 2045)

New Orleans, Louisiana 70121, United States

University of Maryland ( Site 2031)

Baltimore, Maryland 21201, United States

Dana Farber Cancer Center ( Site 1873)

Boston, Massachusetts 02215, United States

University of Massachusetts Memorial Medical Center ( Site 1875)

Worcester, Massachusetts 01655, United States

Karmanos Cancer Institute ( Site 1870)

Detroit, Michigan 48201, United States

Henry Ford Health System ( Site 1803)

Detroit, Michigan 48202, United States

Southdale Cancer Care, University of Minnesota Medical Center- Edina ( Site 2016)

Edina, Minnesota 55435, United States

University of Missouri Hospital-Otolaryngology - Head and Neck Surgery ( Site 2058)

Columbia, Missouri 65212, United States

Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center ( Site 1897)

Springfield, Missouri 65804, United States

Washington University School of Medicine ( Site 1800)

St Louis, Missouri 63110, United States

St. Vincent Healthcare Frontier Cancer Center ( Site 1818)

Billings, Montana 59102, United States

Memorial Sloan Kettering Cancer Center Basking Ridge ( Site 2036)

Basking Ridge, New Jersey 07920, United States

Memorial Sloan Kettering Cancer Center- Monmouth ( Site 2039)

Middletown, New Jersey 07748, United States

MSKCC-Bergen ( Site 2037)

Montvale, New Jersey 07645, United States

Rutgers Cancer Institute of New Jersey ( Site 2071)

New Brunswick, New Jersey 08903, United States

Rutgers New Jersey Medical School-department of Hematology oncology ( Site 2053)

Newark, New Jersey 07103, United States

The University of New Mexico Comprehensive Cancer Center ( Site 1882)

Albuquerque, New Mexico 87131-0001, United States

Erie County Medical Center ( Site 2047)

Buffalo, New York 14215, United States

Memorial Sloan-Kettering Cancer Center at Commack ( Site 2038)

Commack, New York 11725, United States

Memorial Sloan-Kettering Cancer Center at West Harrison ( Site 2041)

Harrison, New York 10604, United States

Monter Cancer Center ( Site 2060)

Lake Success, New York 11042, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 2014)

New York, New York 10016, United States

Memorial Sloan Kettering Cancer Center ( Site 1857)

New York, New York 10021, United States

Weill Cornell Medical College ( Site 2050)

New York, New York 10065, United States

Northwell Health Cancer Institute ( Site 2030)

New York, New York 10075, United States

Stony Brook University ( Site 2063)

Stony Brook, New York 11794, United States

Montefiore Einstein Center ( Site 2028)

The Bronx, New York 10467, United States

Memorial Sloan Kettering Cancer Center - Nassau ( Site 2040)

Uniondale, New York 11553, United States

Levine Cancer Institute ( Site 2003)

Charlotte, North Carolina 28204, United States

Wake Forest Compenhensive Cancer Center ( Site 2029)

Winston-Salem, North Carolina 27357, United States

Sanford Health Roger Maris Cancer Center ( Site 2034)

Fargo, North Dakota 58122, United States

University Hospitals ( Site 2032)

Cleveland, Ohio 44106, United States

The Ohio State University ( Site 2012)

Columbus, Ohio 43210, United States

Providence Portland Medical Center ( Site 1843)

Portland, Oregon 97220, United States

Kaiser Permanente Center for Health Research-Kaiser Permanente Medical Center ( Site 2022)

Portland, Oregon 97227, United States

Oregon Health Science University ( Site 1871)

Portland, Oregon 97239, United States

St. Luke's University Health Network ( Site 1801)

Bethlehem, Pennsylvania 18015, United States

Sidney Kimmel Cancer Center - Jefferson Health ( Site 2059)

Philadelphia, Pennsylvania 19107, United States

Allegheny General Hospital ( Site 1833)

Pittsburgh, Pennsylvania 15212, United States

Sanford Cancer Center Oncology Clinic ( Site 1859)

Sioux Falls, South Dakota 57104, United States

Avera Cancer Institute- Research ( Site 2070)

Sioux Falls, South Dakota 57105, United States

Henry Joyce Cancer Clinic ( Site 1827)

Nashville, Tennessee 37232, United States

UT Southwestern Medical Center ( Site 1841)

Dallas, Texas 75390, United States

USA Clinical Trials ( Site 2068)

San Antonio, Texas 78229, United States

University of Utah, Huntsman Cancer Institute ( Site 1855)

Salt Lake City, Utah 84112-5550, United States

University of Vermont Medical Center ( Site 2009)

Burlington, Vermont 05401, United States

UVA Health System - Emily Couric Cancer Center ( Site 1826)

Charlottesville, Virginia 22908, United States

Inova Schar Cancer Institute ( Site 2026)

Fairfax, Virginia 22031, United States

Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 1865)

Seattle, Washington 98109, United States

Hospital Universitario Austral ( Site 0009)

Pilar, Buenos Aires B1629AHJ, Argentina

Centro de Educación Médica e Investigaciones Clínicas (CEMIC)-Medical Oncology ( Site 0019)

Buenos Aires, Buenos Aires F.D. C1431FWO, Argentina

Hospital Britanico de Buenos Aires ( Site 0012)

Ciudad de Buenos Aires, Buenos Aires F.D. C1280AEB, Argentina

Sanatorio Britanico ( Site 0013)

Rosario, Santa Fe Province S2000CVB, Argentina

Fundacion Estudios Clinicos-Oncology ( Site 0017)

Rosario, Santa Fe Province S2000DEJ, Argentina

Instituto de Oncologia de Rosario ( Site 0002)

Rosario, Santa Fe Province S2000KZE, Argentina

Hospital Provincial del Centenario ( Site 0008)

Rosario, Santa Fe Province S2002KDS, Argentina

IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 0016)

Buenos Aires, C1012AAR, Argentina

Hospital Aleman Buenos Aires Argentina ( Site 0004)

Buenos Aires, C1118AAT, Argentina

Instituto de Oncología Angel Roffo ( Site 0003)

Buenos Aires, C1417DTB, Argentina

CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica ( Site 0010)

San Juan, J5402DIL, Argentina

The Crown Princess Mary Cancer Centre - Westmead Hospital ( Site 0051)

Westmead, New South Wales 2145, Australia

Royal Brisbane and Women s Hospital ( Site 0050)

Herston, Queensland 4029, Australia

Landeskrankenhaus - Universitatsklinikum Graz ( Site 1902)

Graz, Styria 8036, Austria

Ordensklinikum Linz Gmbh - Barmherzige Schwestern ( Site 1901)

Linz, Upper Austria 4010, Austria

Landeskrankenhaus Salzburg - Universitatklinikum der PMU ( Site 1900)

Salzburg, 5020, Austria

Medizinische Universität Wien ( Site 1903)

Vienna, 1090, Austria

Hopital de Jolimont ( Site 0103)

Haine-Saint-Paul, Hainaut 7100, Belgium

UZ Gent ( Site 0101)

Ghent, Oost-Vlaanderen 9000, Belgium

AZ Nikolaas ( Site 0104)

Sint-Niklaas, Oost-Vlaanderen 9100, Belgium

Centro Regional Integrado de Oncologia ( Site 0160)

Fortaleza, Ceará 60336-232, Brazil

Hospital Santa Izabel - Santa Casa de Misericordia da Bahia ( Site 0155)

Salvador, Estado de Bahia 40050-410, Brazil

Hospital Marcio Cunha-Unidade de Pesquisa Clínica ( Site 0177)

Ipatinga, Minas Gerais 35162-189, Brazil

Liga Norte Riograndense Contra o Cancer ( Site 0171)

Natal, Rio Grande do Norte 59075-740, Brazil

Hospital Nossa Senhora da Conceicao ( Site 0165)

Porto Alegre, Rio Grande do Sul 91359-200, Brazil

Hospital de Base de Sao Jose de Rio Preto ( Site 0153)

São José do Rio Preto, São Paulo 15090-000, Brazil

Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0169)

Rio de Janeiro, 20231-050, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0167)

São Paulo, 01246-000, Brazil

BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0175)

São Paulo, 01321-001, Brazil

Cross Cancer Institute ( Site 0201)

Edmonton, Alberta T6G 1Z2, Canada

Sunnybrook Research Institute ( Site 0211)

Toronto, Ontario M4N 3M5, Canada

Princess Margaret Cancer Centre ( Site 0202)

Toronto, Ontario M5G 2M9, Canada

McGill University Health Centre ( Site 0210)

Montreal, Quebec H4A 3J1, Canada

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0209)

Sherbrooke, Quebec J1H 5N4, Canada

Fundacion Arturo Lopez Perez FALP ( Site 0251)

Santiago, Region M. de Santiago 7500921, Chile

Clinica de la Costa S.A.S. ( Site 0307)

Barranquilla, Atlántico 080020, Colombia

Centro de Investigacion Clinica del Country ( Site 0304)

Bogotá, Bogota D.C. 110221, Colombia

Oncologos del Occidente S.A. ( Site 0310)

Pereira, Risaralda Department 661002, Colombia

Centro Medico Imbanaco de Cali S.A ( Site 0300)

Cali, Valle del Cauca Department 760042, Colombia

Centre Antoine Lacassagne ( Site 0351)

Nice, Alpes-Maritimes 06189, France

Hopital de la Timone ( Site 0356)

Marseille, Bouches-du-Rhone 13385, France

Institut Claudius Regaud IUCT Oncopole ( Site 0355)

Toulouse, Haute-Garonne 31059, France

Institut Gustave Roussy ( Site 0353)

Villejuif, Val-de-Marne 94800, France

Institut Sainte Catherine ( Site 0352)

Avignon, Vaucluse 84918, France

Hopital Europeen Georges Pompidou ( Site 0358)

Paris, 75015, France

Institut Curie ( Site 0350)

Paris, 75248, France

Universitaetsklinikum Tuebingen - Medizinische Klinik ( Site 0401)

Tübingen, Baden-Wurttemberg 72076, Germany

Universitaetsklinikum Ulm. ( Site 0402)

Ulm, Baden-Wurttemberg 89075, Germany

Universitaetsklinikum Erlangen-Strahlenklinik ( Site 0412)

Erlangen, Bavaria 91054, Germany

Klinikum rechts der Isar der Technischen Universitaet ( Site 0409)

Munich, Bavaria 81675, Germany

Klinikum rechts der Isar der Technischen Universität München-HNO Klinik ( Site 0405)

München, Bavaria 81675, Germany

Universitaetsklinikum Frankfurt ( Site 0403)

Frankfurt am Main, Hesse 60590, Germany

Klinikum Kassel GmbH ( Site 0404)

Kassel, Hesse 34125, Germany

Universitaetsklinikum Koeln ( Site 0413)

Cologne, North Rhine-Westphalia 50937, Germany

Universitätsklinikum Schleswig-Holstein ( Site 0411)

Lübeck, Schleswig-Holstein 23538, Germany

SRH Wald-Klinikum Gera GmbH ( Site 0406)

Gera, Thuringia 07548, Germany

Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 0414)

Berlin, 12203, Germany

Universitaetsklinikum Hamburg Eppendorf ( Site 0407)

Hamburg, 20246, Germany

Pecsi Tudomanyegyetem Onkoterapias Intezet ( Site 0452)

Pécs, Baranya 7621, Hungary

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 0450)

Szolnok, Jász-Nagykun-Szolnok 5004, Hungary

Eszak-Pesti Centrumkorhaz-Honvedkorhaz ( Site 0453)

Budapest, 1062, Hungary

Orszagos Onkologiai Intezet-Sugarterapias Kozpont ( Site 0454)

Budapest, 1122, Hungary

St. James s Hospital ( Site 0500)

Dublin, Dublin 8, Ireland

Rambam Health Care Campus-Oncology Division ( Site 0550)

Haifa, 3109601, Israel

Hadassah Medical Center. Ein Kerem ( Site 0554)

Jerusalem, 9112001, Israel

Rabin Medical Center ( Site 0552)

Petah Tikva, 4963211, Israel

Chaim Sheba Medical Center. ( Site 0553)

Ramat Gan, 5265601, Israel

Sourasky Medical Center ( Site 0551)

Tel Aviv, 6423906, Israel

Aichi Cancer Center ( Site 0658)

Nagoya, Aichi-ken 464-8681, Japan

National Cancer Center Hospital East ( Site 0661)

Kashiwa, Chiba 277-8577, Japan

Hyogo Cancer Center ( Site 0656)

Akashi, Hyōgo 673-8558, Japan

Kagawa University Hospital ( Site 0651)

Kita-gun, Kagawa-ken 761-0793, Japan

Yokohama City University Hospital ( Site 0657)

Minato, Tokyo 107-0052, Japan

Chiba Cancer Center ( Site 0652)

Chiba, 260-8717, Japan

National Hospital Organization Kyushu Cancer Center ( Site 0660)

Fukuoka, 811-1395, Japan

Hiroshima University Hospital ( Site 0655)

Hiroshima, 734-8551, Japan

National Cancer Center Hospital ( Site 0650)

Tokyo, 104-0045, Japan

Institute of Science Tokyo Hospital ( Site 0654)

Tokyo, 113-8519, Japan

Tokyo Medical University Hospital ( Site 0659)

Tokyo, 160-0023, Japan

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 0905)

Krakow, Lesser Poland Voivodeship 31-826, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 0940)

Warsaw, Masovian Voivodeship 02-781, Poland

Szpitale Pomorskie Sp. z o.o. ( Site 0935)

Gdynia, Pomeranian Voivodeship 81-159, Poland

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 0901)

Gliwice, Silesian Voivodeship 44-102, Poland

Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi ( Site 0920)

Lodz, Łódź Voivodeship 93-513, Poland

Unidade Local de Saude de Braga - Hospital de Braga ( Site 0951)

Braga, 4710-243, Portugal

Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 0952)

Lisbon, 1649-035, Portugal

Hospital CUF Descobertas ( Site 0953)

Lisbon, 1998-018, Portugal

Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0950)

Porto, 4200-072, Portugal

N.N. Blokhin NMRCO ( Site 1005)

Moscow, Moscow 115478, Russia

Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 1000)

Kazan', Tatarstan, Respublika 420029, Russia

Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1001)

Yaroslavl, Yaroslavl Oblast 150054, Russia

Chonnam National University Hwasun Hospital ( Site 0705)

Hwasun Gun, Jeonranamdo 58128, South Korea

National Cancer Center ( Site 0702)

Goyang-si, Kyonggi-do 10408, South Korea

Seoul National University Bundang Hospital ( Site 0703)

Seongnam-si, Kyonggi-do 13620, South Korea

The Catholic University of Korea St. Vincent s Hospital ( Site 0704)

Suwon, Kyonggi-do 16247, South Korea

Severance Hospital, Yonsei University Health System ( Site 0701)

Seoul, 03722, South Korea

Hospital Germans Trias i Pujol. ICO de Badalona ( Site 1204)

Badalona, Barcelona 08916, Spain

ICO L Hospitalet ( Site 1208)

L'Hospitalet de Llobregat, Barcelona 08908, Spain

Hospital Clinico Universitario de Santiago ( Site 1207)

Santiago de Compostela, La Coruna 15706, Spain

Hospital Vall D Hebron ( Site 1200)

Barcelona, 08035, Spain

Hospital Universitario La Paz ( Site 1201)

Madrid, 28046, Spain

Hospital Universitario Virgen del Rocio ( Site 1206)

Seville, 41013, Spain

Universitaetsspital Zurich ( Site 1923)

Zuerich, Canton of Aargau 8091, Switzerland

Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 1921)

Bellinzona, Canton Ticino 6500, Switzerland

Hopitaux Universitaires de Geneve HUG ( Site 1920)

Geneva, 1211, Switzerland

Chang Gung Medical Foundation. Kaohsiung Branch ( Site 1303)

Kaohsiung City, 833, Taiwan

Taichung Veterans General Hospital ( Site 1301)

Taichung, 40705, Taiwan

National Cheng Kung University Hospital ( Site 1302)

Tainan, 704, Taiwan

National Taiwan University Hospital ( Site 1300)

Taipei, 10002, Taiwan

Clinical oncology dispensary of Dnipro ( Site 1706)

Dnipro, Dnipropetrovsk Oblast 49055, Ukraine

Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council ( Site 1705)

Dnipro, Dnipropetrovsk Oblast 49102, Ukraine

Dnipropetrovsk Regional Hospital n.a. I.I. Mechnikov ( Site 1709)

Dnipropetrovsk, Dnipropetrovsk Oblast 49005, Ukraine

Ukrainian Center of Tomotherapy ( Site 1708)

Kropyvnitskiy, Kirovohrad Oblast 25011, Ukraine

PP PPC Acinus Medical and Diagnostic Centre ( Site 1704)

Kropyvnytskyi, Kirovohrad Oblast 25006, Ukraine

LISOD. Hospital ( Site 1707)

Pliuty, Kyiv Oblast 08720, Ukraine

Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 1703)

Kapitanivka Village, Kyivska Oblast 08111, Ukraine

SNPE National Cancer Institute ( Site 1702)

Kyiv, Kyivska Oblast 03022, Ukraine

Kyiv City Clinical Oncology Centre ( Site 1701)

Kyiv, 03115, Ukraine

Addenbrooke's Hospital ( Site 1610)

Cambridge, Cambridgeshire CB2 2QQ, United Kingdom

Castle Hill Hospital ( Site 1601)

Cottingham-Hull, Kingston Upon Hull HU16 5JQ, United Kingdom

Guy s & St Thomas NHS Foundation Trust ( Site 1604)

London, London, City of SE1 9RT, United Kingdom

Royal Marsden Hospital - Fulham Road London ( Site 1609)

London, London, City of SW3 6JJ, United Kingdom

Imperial College Healthcare NHS Trust, Charing Cross Hospital ( Site 1603)

London, London, City of W6 8RF, United Kingdom

Weston Park Hospital ( Site 1607)

Sheffield, S10 2SJ, United Kingdom