Study did not get funded

There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis.

In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation

Inclusion Criteria:

BMI 27.5-35

Exclusion Criteria:

• BMI <27.5 or >35
• high physical activity
• diabetes
• impaired liver or kidney function
• cardiovascular disease
• weight change of more than 3 kg in the past month
• pregnancy
• previous surgery on digestive tract (except appendectomy)
• fluid balance will be exclusionary such as
• serotonin re-uptake inhibitors.