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Realization of transcranial doppler and optic nerve sheath in severe preeclamptic patients to evaluate the impact of nicardipine and labetalol on cerebral hemodynamics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Labetalol | Patients who will receive labetalol in IV route in first intention |
| |
| Nicardipine | Patients who will receive nicardipine in IV route in first intention |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| optic nerve sheath measurement and transcranial doppler | Diagnostic Test | evaluation of cerebral hemodynamics through measurement of systolic and diastolic velocities and PI in middle cerebral artery. Intracranial pressure will be appreciate by optic nerve sheath value |
| Measure | Description | Time Frame |
|---|---|---|
| Change of values obtained by ultrasonography optic nerve sheath measurement from baseline to 2 hours post starting infusion of nicardipine or labetalol. | Variation of values will be studied during a 2 hour time period, starting just before administration of either labetalol or nicardipine by i.v. route | just before treatment and 2 hours after |
| Measure | Description | Time Frame |
|---|---|---|
| variation of diastolic and systolic velocities in middle cerebral artery before and after administration of either labetalol or nicardipine by i.v. route | values are obtained by transcranial doppler | just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours |
| variation of PI in middle cerebral artery before and after administration of either labetalol or nicardipine by i.v. route |
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Inclusion Criteria:
Exclusion Criteria:
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women with severe preeclampsia and antihypertensive drug administrated by i.v. route
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mickaël SOUED | Contact | +33145374273 | mickael.soued@aphp.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Béclère | Recruiting | Clamart | 92140 | France |
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| ID | Term |
|---|---|
| D017585 | Ultrasonography, Doppler, Transcranial |
| ID | Term |
|---|---|
| D004453 | Echoencephalography |
| D009485 | Neuroradiography |
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
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values are obtained by transcranial doppler |
| just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours |
| proportion of pathologic PI in middle cerebral artery in each group | values are obtained by transcranial doppler | just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours |
| proportion of optic nerve sheath up to 5.8 mm in each group | values are obtained by ultrasonography | just before treatment and at 30 minutes to 60 minutes, 2 hours to 3 hours and 6 hours to 8 hours |
| values of optic nerve sheath diameter in each group | values are obtained by ultrasonography | At 30 minutes to 60 minutes and 6 hours to 8 hours |
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011859 | Radiography |
| D014463 | Ultrasonography |
| D018608 | Ultrasonography, Doppler |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |