Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections

Comparison of Hyaluronic Acid and Platelet-rich Plasma Injection on Pain, Physical Function and Femoral Cartilage Thickness in Patients With Osteoarthritis

This study aims to compare the effects of hyaluronic acid injection and platelet rich plasma injection in terms of pain, physical function and femoral cartilage thickness in short term treatment in patients with knee osteoarthritis.

Platelet-rich plasma and hyaluronic acid injections are both popular treatments and commonly used for treatment of knee osteoarthritis. Even though there are many studies investigating the effectiveness of these treatments, the results are mostly qualitative. Also there are a few studies comparing these two treatment modalities. In this study the investigators aim to compare these modalities both for self-reported data (pain, physical function) and objective measurement data (femoral cartilage thickness via ultrasonography). Patients with unilateral osteoarthritis/unilateral complaint will be included in the study. Unaffected side will be controls for each group.

Inclusion Criteria:

• Subject is able to consent
• Subject meets Osteoarthritis Research Society International (OARSI) criteria for knee osteoarthritis
• Subject has radiographic Kellgren-Lawrence grade 2-3 osteoarthritis
• Unilateral osteoarthritis/complaint

Exclusion Criteria:

• Past or actual knee infection
• History of surgery, fracture on knee
• Collagen tissue disease
• Systemic inflammatory disease (rheumatoid arthritis, spondyloarthritis etc.)
• Systemic diseases (diabetes, hematologic diseases, endocrinopathies, renal failure, liver failure)
• Knee injection in past 6 months
• Immunodeficiency
• Pregnant/breastfeeding
• Malignancy