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Cardiovascular disease (CVD) is the major risk factor for death in end stage renal diseases (ESRD). Approximately 80% of ESRD patients have some degrees of left ventricular abnormalities at initiation of dialysis. Carotid intima media thickness (CIMT) has been widely accepted as an useful marker to assess CVD in ESRD children. In addition, cardiac mechanics parameters are used to evaluate cardiac function more precisely. However, measuring CIMT and cardiac mechanics parameters are expensive and difficult to perform as a routine method. Mean platelet volume (MPV) is a hematological index which shows the size of platelets. Uremic state causes inflammatory condition that affects MPV. Previous studies on people with normal renal function have shown that this parameter can also have association with CVD. However the data in children with ESRD is scarce. The aim of this study is to find a simple hematologic marker to use regularly in ESRD children finding patients at risk of CVD. Therefore, we will investigate the relationship between mean platelet volume and CIMT and cardiac mechanic parameters in children with ESRD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Children with end stage renal disease |
| |
| Controls | Healthy sex- and age adjusted children |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Imaging | Diagnostic Test | Imaging including Echocardiography for determining cardiac indices (ejection fraction, left ventricular mass index, strain rate, global longitudinal strain) and Doppler ultrasound for measuring carotid intima media thickness |
| Measure | Description | Time Frame |
|---|---|---|
| MPV in patients and controls | Comparing the mean of MPV in patients and controls. | 1 year after study beginning |
| Echocardiographic indices in patients and controls | Comparing the means of echocardiographic indices in patients and controls | 1.5 years after study beginning |
| Carotid intima media thickness in patients and controls | Comparing the mean of carotid intima media thickness in patients and controls | 2 years after study beginning |
| Correlation between MPV and ejection fraction | Determining correlation between the value of MPV with ejection fraction in patients | 1.5 years after study beginning |
| Correlation between MPV and left ventricular mass index | Determining correlation between the value of MPV with left ventricular mass index in patients | 1.5 years after study beginning |
| Correlation between MPV and strain rate | Determining correlation between the value of MPV with strain rate in patients | 1.5 years after study beginning |
| Correlation between MPV and global longitudinal strain | Determining correlation between the value of MPV with global longitudinal strain in patients | 1.5 years after study beginning |
| Measure | Description | Time Frame |
|---|---|---|
| MPV and thrombotic events | Comparing the values of MPV in patients with and without previous histories of thrombotic events including arteriovenous fistula thrombosis, cerebrovascular accident, deep venous thrombosis, and cerebrovascular accident | 2 years after study beginning |
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Inclusion Criteria:
Exclusion Criteria:
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Patients group will be selected from children who referred to a tertiary care center of pediatric nephrology diseases.
Controls will be chosen from healthy volunteers who will be visited for medical routine examination in the hospital staff.
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| Name | Affiliation | Role |
|---|---|---|
| Alaleh Gheissari, M.D. | Professor of pediatric nephrology | Principal Investigator |
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| Blood sampling | Other | Blood sampling will performed on all participants for measuring hematological parameters including MPV. |
|
| Correlation between MPV and carotid intima media thickness | Determining correlation between the value of MPV with carotid intima media thickness in patients | 2 years after study beginning |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D017379 | Hypertrophy, Left Ventricular |
| D007676 | Kidney Failure, Chronic |
| ID | Term |
|---|---|
| D006332 | Cardiomegaly |
| D006331 | Heart Diseases |
| D006984 | Hypertrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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