A Study of Technology to Improve Glucose Control in Participants With Type 1 Diabetes

Technology-supported, Meal-centric, Insulin Dosing for Optimized Post-prandial Glucose Control

The main purpose of this study is to determine whether combining meal, glucose, and insulin data in a web-based system will improve management of type 1 diabetes (T1D). No study drug will be given. The study will last about 18 weeks.

Inclusion Criteria:

• T1D by clinical diagnosis for > 3 years
• Insulin pump use > 3 months: must use one of the following pump types: Animas Ping and Vibe, Insulet Omnipod, Medtronic 523/723 and 530G, Tandem t:slim and t:flex
• Continuous Glucose Monitor (CGM) > 3 months and current use of Dexcom G5 at least 6 out of 7 days per week
• HbA1c 7.0-9.5%
• Must have iPhone (meal-tagging app has been built on iOS)
• Personal computer for uploading of pump and CGM devices
• Willingness to follow study protocol including tagging food data
• Comfort speaking, reading, and writing English

Exclusion Criteria:

• Individuals currently using a hybrid closed-loop system (e.g., Medtronic 670G)
• Individuals planning to follow a specific diet plan for weight loss
• Inability to consume "common meals"
• Gastroparesis;
• Eating disorder
• Evidence of missed insulin meal-time insulin boluses on pump download
• Use of medications that can affect blood glucose levels (such as SGLT inhibitors, steroid, beta agonists)
• Use of medications that affect gastric emptying (such as GLP agonists, pramlinitide)
• Alcohol abuse
• Pre-conception, pregnancy, or lactation