Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the present study, we intend to identify new related variants or genes. From March, 2003 to November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole exome sequencing was used to find out the variants associated with the onset of cardiomyopathy and its prognosis.

Inclusion Criteria:

· Patients diagnosed as cardiomyopathy according to the definition of American Heart Association

Exclusion Criteria:

• Uncontrolled hypertension significant valvular disease
• Mild ischemic heart disease
• Significant systemic infection
• Thyroid-induced cardiomyopathy
• Excessive alcohol consumption
• Precious cancer treatment including irradiation
• Refusal to participate in the study

hospitalized patients with cardiomyopathy will be enrolled in this study