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To characterize the relationship of renal biomarkers (Creatinine, albumin, Cystatin C, NGAL, beta-trace protein, beta-2 microglobulin, and uromodulin) between each other and the variation over age, measured in serum and urine of healthy children. Unused residual blood and urine samples will be used for testing the renal Parameters.
Despite relevant research in renal biomarkers, there is currently no optimal marker available that reliably quantifies kidney function and indicates kidney injury in its early stages. The combination of two or more biomarkers might be a more promising approach than investigating a single parameter. The relationship of renal biomarkers (creatinine, albumin, Cystatin C, NGAL, beta-trace protein, beta-2 microglobulin, and uromodulin) between each other and the variation over age in infants and children (without chronic kidney disease) is investigated.
The biomarkers in urine samples are explored to find less invasive means of quantifying renal health.
Patients between the age of 0 and 12 years undergoing blood with or without urine sampling as part of their diagnostic workup are eligible for the study. Unused residual blood and urine samples will be used for testing the renal parameters.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood test for renal biomarkers (creatinine, cystatin C, Neutrophil gelatinase-associated lipocalin, beta-trace protein, beta-2 microglobulin, uromodulin) | Other | relationship between the different biomarkers by linear regression analysis is assessed; influence of demographic variables (age, body weight, body surface area) is investigated by multivariate regression. | ||
| urine test for renal biomarkers (creatinine, cystatin C, Neutrophil gelatinase-associated lipocalin, beta-trace protein beta-2 microglobulin, uromodulin, albumin) | Other | relationship between the different biomarkers by linear regression analysis is assessed; influence of demographic variables (age, body weight, body surface area) is investigated by multivariate regression. |
| Measure | Description | Time Frame |
|---|---|---|
| Serum concentration of creatinine (ymol/l) | blood test for renal biomarker | single point in time at subject enrollment |
| Serum concentration of cystatin C (mg/l) | blood test for renal biomarker | single point in time at subject enrollment |
| Serum concentration of Neutrophil gelatinase-associated lipocalin (ng/ml) | blood test for renal biomarker | single point in time at subject enrollment |
| Serum concentration of beta-trace Protein (mg/l) | blood test for renal biomarker | single point in time at subject enrollment |
| Serum concentration of beta-2 Microglobulin (mg/l) | blood test for renal biomarker | single point in time at subject enrollment |
| Serum concentration of Uromodulin (ng/ml) | blood test for renal biomarker | single point in time at subject enrollment |
| Urine concentration of creatinine (mmols/kg/24h) | Urine test for renal biomarker | single point in time at subject enrollment |
| Urine concentration of cystatin C (mg/l) | Urine test for renal biomarker |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy patients between the age of 0 and 15 years visiting the Short Stay Unit of the University of Basel Children's Hospital for elective surgery and requiring venous access via peripheral venous canula are eligible for study participation
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| Name | Affiliation | Role |
|---|---|---|
| Marc Pfister, Prof. Dr. MD | University of Basel Children's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Basel Children's Hospital | Basel | 4031 | Switzerland |
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| single point in time at subject enrollment |
| Urine concentration of Neutrophil gelatinase-associated lipocalin (yg/l) | Urine test for renal biomarker | single point in time at subject enrollment |
| Urine concentration of beta-trace Protein (mg/l) | Urine test for renal biomarker | single point in time at subject enrollment |
| Urine concentration of beta-2 microglobulin (mg/l) | Urine test for renal biomarker | single point in time at subject enrollment |
| Urine concentration of uromodulin (ng/ml) | Urine test for renal biomarker | at time of enrollment |
| Urine concentration of Albumin (mg/l) | Urine test for renal biomarker | at time of enrollment |
| Plasma protein binding of survival motor neuron (SMN) 2 splicing modifiers | blood test for spinal muscular atrophy | single point in time at subject enrollment |
| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| D003404 | Creatinine |
| D055316 | Cystatin C |
| D000071068 | Lipocalin-2 |
| C022466 | prostaglandin R2 D-isomerase |
| D001613 | beta 2-Microglobulin |
| D058949 | Uromodulin |
| D016482 | Urinalysis |
| D000418 | Albumins |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D015891 | Cystatins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000209 | Acute-Phase Proteins |
| D001798 | Blood Proteins |
| D054834 | Lipocalins |
| D002352 | Carrier Proteins |
| D011518 | Proto-Oncogene Proteins |
| D015513 | Oncogene Proteins |
| D009363 | Neoplasm Proteins |
| D015395 | Histocompatibility Antigens Class I |
| D008562 | Membrane Glycoproteins |
| D006023 | Glycoproteins |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D001609 | Beta-Globulins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
| D008565 | Membrane Proteins |
| D006649 | Histocompatibility Antigens |
| D000954 | Antigens, Surface |
| D000941 | Antigens |
| D001685 | Biological Factors |
| D007519 | Isoantigens |
| D058851 | GPI-Linked Proteins |
| D009088 | Mucoproteins |
| D058635 | Lipid-Linked Proteins |
| D019963 | Clinical Chemistry Tests |
| D003950 | Diagnostic Techniques, Urological |
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