Inferior alveolar nerve block using either 0.5% bupivacaine alone or in addittion to mannitol in patients with irreversible pulpitis in mandibular molars.

Patients with irreversible pulpitis in mandibular molars will be selected according to the eligibility criteria and patients are then randomized to either using 0.5% bupivacaine alone or in addition to mannitol. Anesthetic success and postoperative pain will then be assessed.

Inclusion Criteria:

1. Adult patients; age between 17-35 years old.
2. Males or Females.
3. Medically-free patients
4. Patients suffering from symptomatic irreversible pulpitis without apical periodontitis in mandibular molar teeth.
5. Positive patients' acceptance for participation in the study.

Exclusion Criteria:

• Patients who had any analgesic during proceeding 12 hours before the treatment.
• Teeth with necrotic, infected pulp, swelling or symptomatic apical periodontitis (apical abscess).
• Pregnant females.
• Patients with history of significant medical conditions (contraindication of mannitol use).
• Addiction
• Psycological disturbance.