Identification of Microbial Properties Predicting a Worsening Course of Fatty Liver Disease

Identification of Microbial Properties Predicting a Worsening Course of Fatty Liver Disease

This study investigates the relation between the gastrointestinal tract bacteria and the progression of fatty liver disease .

In the gastrointestinal (GI) tract live wide spectrum of bacteria, in this study we are trying to find if there is a relation between the GI tract bacteria and the development of non alcoholic fatty liver disease, the results of the this study may help us identify the stage of liver disease in noninvasive means and enables us to adopt methods to reduce morbodity.

Inclusion Criteria:

• patients with non alcoholic fatty liver disese.
• patients who give approval to participate in the study

Exclusion Criteria:

• liver failure
• acute or chronic kidney failure
• heart failure ( NYHA 3-4)
• active cancer
• fatty liver due to non alcoholic etiology.
• patients who consume drugs from the estrogen/methotrexate family, or chloroquine.
• history of hypothyrodism or cushing.
• patients who used TPA in the last 6 months .
• pathients with chronic liver disease like A1AT, hemochromatosis, wilson, toxic damage and autoimmunity .
• special population like - children, pregnant women and patients who lack the ability to make judgment.
• infectious liver disease - viral hepatitis or HIV.
• inflammatory bowel disease.
• patients who underwent surgery of the gastrointestinal trant.