Determination of Baseline Thyroid Status Values in French Adult Population

Determination of Baseline Thyroid Status Values

The objective of this study is to establish reference values in the general population from a Beckman Coulter DxI chemiluminescence assay.

Indeed, the lack of harmonization of the methods of the dosage remains a major difficulty to optimize the management of patients with thyroid disease.

This supplier has recently optimized its dosing kit according to the 3rd international standard of the WHO (IRB 81/565) for the TSH (Thyroid Stimulating Hormon).

It is necessary to carry out a study of the distribution of the values of this TSH within our metropolitan population. The current data proposed by the supplier come from a study of a North American population.

investigators propose to define usual values for thyroid status markers (TSH, FT4 [free thyroxine], FT3 [free triiodothyroxine]) from healthy EFS (French Blood Establishment) donors who meet the standard exclusion criteria for this type of study.

Inclusion Criteria:

• Donors (18-70 years old) volunteers at EFS

Exclusion Criteria:

• pregnancy,
• known antecedents of thyroid diseases (goiter, nodule, hypo or hyperthyroidism),
• current antithyroid treatment (neomercazole [Thyrozol(r)], levothyroxyn LT4 [levothyrox(r)], ...),
• cardiac treatment with amiodarone (cordarone(r)),
• injection of iodinated contrast medium less than 1 month old