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It is already known from literature that exercise mobilizes stem and progenitor cells into the peripheral blood. However, the exact mechanisms thereof remain to be fully elucidated.
The investigators hypothesize that exercise-induced oxidative stress could be at least one of the responsible mechanisms and therefore want to study the exercise-induced stem and progenitor cell mobilization in a group of healthy young men when they exercise with, compared to when they exercise without antioxidative supplementation.
The primary outcome is numbers of stem and progenitor cells in the peripheral blood after an acute bout of exercise. As a secondary outcome, numbers of apoptotic mature and immature cells in the blood will be analysed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Antioxidative Supplementation | Experimental | Each participant conducts two identical cycling tests, first without and a week later with antioxidative supplementation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Antioxidative supplementation | Dietary Supplement | Each participant conducts two identical cycling tests, first without and a week later with antioxidative supplementation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in exercise-dependently mobilized stem and progenitor cell numbers in the peripheral blood with antioxidative supplementation | Numbers of hematopoietic, endothelial and mesenchymal stem and progenitor cells and mature endothelial cells in the peripheral blood will be measured after an acute bout of exercise first without and then with prior antioxidative supplementation. | On visit 2 after the exercise test without supplementation and then again on visit 3 after the exercise test with prior supplementation (1 week) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in numbers of exercise-induced apoptotic cells and oxidative stress markers in the peripheral blood with antioxidative supplementation | Numbers of apoptotic mononuclear cells, apoptotic hematopoietic, endothelial and mesenchymal stem and progenitor cells and apoptotic mature endothelial cells, as well as in oxidative stress markers in the peripheral blood will be measured after an acute bout of exercise first without and then with prior antioxidative supplementation. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich | Zurich | Canton of Zurich | 8057 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34955891 | Derived | Schmid M, Martins HC, Schratt G, Kropfl JM, Spengler CM. MiRNA126 - RGS16 - CXCL12 Cascade as a Potential Mechanism of Acute Exercise-Induced Precursor Cell Mobilization. Front Physiol. 2021 Dec 9;12:780666. doi: 10.3389/fphys.2021.780666. eCollection 2021. |
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Each participant enrolled in the study will be part of the supplementation and control condition group in a non-randomized order
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| On visit 2 after the exercise test without supplementation and then again on visit 3 after the exercise test with prior supplementation (1 week) |