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HIV infection is associated to premature decline of serum testosterone. However, prevalence and biochemical characterization of hypogonadism in HIV-infected men are still to be well defined. HIV-infection is strongly associated to erectile dysfunction in men, but preliminary data suggest that it is poorly associated with serum testosterone in this context.
The aim of this study is to evaluate the gonadal function of young to middle aged HIV-infected men in order to characterize hypogonadism by assessing circulating total testosterone with either Liquid Chromatography tandem Mass Spectrometry (LC-MS/MS) or chemiluminescent immunoassay. Furthermore, secondary aim is to assess the erectile function through the use of validated questionnaires (International Index of Erectile Function (IIEF) 15 and 5).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIV-infected male patients | Male patients (age 18-50 years) with HIV-infection and ongoing HAART therapy No intervention is provided |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention is provided | Other | No intervention is provided |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum total testosterone | From blood sample - unit of measurement ng/dL | Assessed only once at the moment of enrollment with liquid chromatography tandem mass spectrometry |
| Serum total testosterone | From blood sample - unit of measurement ng/dL | Assessed only once at the moment of enrollment with chemiluminiscent immunoassay |
| Measure | Description | Time Frame |
|---|---|---|
| Serum free testosterone | Calculated formula (Vermeulen equation) | Calculated only once at the moment of enrollment |
| Score at IIEF questionnaire | Total score at erectile function domain of IIEF-15 questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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Cohort of Young-to-Middle Aged HIV-infected Patients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedaliero - Universitaria di Modena | Modena | 41124 | Italy |
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| D005058 | Eunuchism |
| D007172 | Erectile Dysfunction |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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Blood sample for hormonal assay
| Assessed only once at the moment of enrollment |
| D015229 |
| Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D007006 | Hypogonadism |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D005832 | Genital Diseases, Male |
| D012735 | Sexual Dysfunction, Physiological |
| D052801 | Male Urogenital Diseases |
| D020018 | Sexual Dysfunctions, Psychological |
| D001523 | Mental Disorders |