because of the Covid pandemic, group meditation could not be carried out and was not repeated in the study.

The objective of this project is to study the influence of mindfulness meditation on psychological health (stress level, affects, emotions) and physical health parameters (rate of inflammatory markers in the blood, activity of white blood cells involved in immuno-inflammation) in caregivers of people with psychiatric disorders. This study will provide the objective scientific data required for the development of mindfulness meditation programs for psychiatric caregivers.

80 participants will be randomly assigned to one of the following two groups:

• 40 participants in the "Mindfulness" group who will attend mindfulness meditation sessions in addition to their standard follow-up
• 40 participants in the "Control" group who will have a standard follow-up The duration of participation is 12 months and includes 3 visits and 8 mindfulness-based meditation sessions for the "Mindfulness" group.

Inclusion Criteria:

• patient who has given oral consent
• adult patient
• a caregiver of a person with a severe psychiatric disorder (schizophrenia, recurrent depression, bipolar disorder, obsessive-compulsive disorder)

Exclusion Criteria:

• protected adult
• patient not affiliated to the national health insurance system
• pregnant, parturient or breastfeeding woman
• person suffering from a severe psychiatric disorder indicating a state of decompensated stress (with risk of associated biological inflammatory disturbances)
• person suffering from an inflammatory disease (autoimmune, infectious, neoplastic, cardio-vascular pathologies