Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from December 2016-November 2017. Patients were informed about the surgical procedure and signed a consent form. Groups were divided in to 4; as control, MTA (mineral trioxide aggregate), PRF (platelet rich fibrin) and MTA+PRF groups. Apical resection was performed in all groups. No other interventions were made to the control group.
Routine radiographs were taken in the 1st. 3th and 6th months. In the (approximately) 12th month of the procedures computerized tomography scans were taken. Primary healing of the periapical tissues were evaluated and the outcomes were measured. Patients have still been under control for the long term outcomes of the study.
44 apically infected periapical lesions were decided to enroll to the study from December 2016-November 2017. However; a total of 40 periapical lesions undergoing apical surgery were recruited for the planned clinical trial in the end. The study was conducted under randomized controlled protocol. Patients were informed about the surgical procedures and signed a consent form. The anticipated outcomes, possible risks and benefits of the study as well as the alternative treatment options were explained to the patients.
Groups were designed to have 10 patients in each and randomly divided into four as; control, MTA, PRF and MTA+PRF. Apical resection was performed in all groups. No other interventions were made to the control group.
Routine radiographs were taken in the 1st. 3th and 6th months. In the 12th month of the procedures computerized tomography (CT) scans were taken. Primary healing of the periapical tissues were evaluated according to the volumes and the densities of the lesions. Outcomes were measured. Comparison between the initial and the last 3D CT scan volumes were made by medical image processing software (MIMICS, Belgium). Patients have still been under control for the long term outcomes of the study.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Sham Comparator | Apical resection group. Only root resection was applied without any other interventions (like prf or mta) |
|
| MTA group | Experimental | Root resection was applied and MTA was inserted through the apical foramen |
|
| PRF group | Experimental | Root resection was applied and PRF was placed to the surgically prepared area |
|
| MTA + PRF group | Experimental | Root resection was applied. MTA was inserted through the apical foramen and PRF was placed to the surgically prepared area |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| control group | Procedure | a procedure used to prevent or resolves apical periodontitis. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Radiographic success - in volume | Evaluation of tomographic outcomes (differences between preoperative and postoperative volume of periapical lesions) | 1 year |
| Radiographic success - in density | Evaluation of tomographic outcomes (differences between preoperative and postoperative density of periapical lesions) | 1 year |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Nazife Begüm KARAN, PhD, DDS | Recep Tayyip Erdogan University | Principal Investigator |
| Banu Arıcıoğlu, PhD, DDS | Recep Tayyip Erdogan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nazife Begüm KARAN | Ankara | Merkez | 83TR2WATUF | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31321573 | Derived | Karan NB, Aricioglu B. Assessment of bone healing after mineral trioxide aggregate and platelet-rich fibrin application in periapical lesions using cone-beam computed tomographic imaging. Clin Oral Investig. 2020 Feb;24(2):1065-1072. doi: 10.1007/s00784-019-03003-x. Epub 2019 Jul 18. |
Not provided
Not provided
data can be available 6 months after the acceptance of the paper
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D010485 | Periapical Periodontitis |
| ID | Term |
|---|---|
| D010483 | Periapical Diseases |
| D007571 | Jaw Diseases |
| D009057 | Stomatognathic Diseases |
| D010510 | Periodontal Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D035061 | Control Groups |
| D001047 | Apicoectomy |
| C086631 | mineral trioxide aggregate |
| D000068437 | Pemetrexed |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| MTA group | Procedure | a procedure used to prevent or resolves apical periodontitis. |
|
|
| PRF group | Procedure | a procedure that is used for wound healing |
|
|
| MTA + PRF group | Procedure | a procedure used to prevent or resolves apical periodontitis in combination with a procedure that is used for wound healing. |
|
|
| D009059 |
| Mouth Diseases |
| D010518 | Periodontitis |
| D008722 | Methods |
| D019647 | Oral Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D004708 | Endodontics |
| D003813 | Dentistry |
| D006147 | Guanine |
| D007042 | Hypoxanthines |
| D011688 | Purinones |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D005971 | Glutamates |
| D024342 | Amino Acids, Acidic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000600 | Amino Acids, Dicarboxylic |