Carpal tunnel syndrome is a common peripheral entrapment neuropathy, this study aims to investigate if, and to what extent local ozone therapy could offer symptom improvement in scleroderma patients with Carpal tunnel syndrome

Carpal tunnel syndrome (CTS) is the most common compression syndrome the upper extremities. Its problem has a high prevalence ranged estimated prevalence of 3.8% in the general population, 3 and 7.8% in the working population. It occurs at any age, especially in individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. A lot of treatment modalities have been tried to improve the condition, starting from local anesthetic injection, steroid, and up to surgical decompression of the nerves.

Scleroderma patients are a special group which usually sufferers from such problem

Inclusion Criteria:

• adult patients with scleroderma
• complaining of carpal tunnel syndrome of 3-month duration or more
• diagnosed axonal neuropathy using electrodiagnosis, nerve conduction study

Exclusion Criteria:

• patient refusal
• infection at the site of intervention
• previous injection in the recent 3 months
• Coagulopathy