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| Name | Class |
|---|---|
| Kellogg Company | INDUSTRY |
| University of Toronto | OTHER |
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To investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Viscosity | Experimental | viscous fibre blend added to breakfast cereals consumed in the context of a typical North American diet for 3 weeks duration |
|
| Medium Viscosity | Experimental | Kellogg's Bran buds with psyllium breakfast cereal consumed in the context of a typical North American diet for 3 weeks duration |
|
| Low Viscosity | Experimental | Kellogg's All Bran breakfast cereal consumed in the context of a typical North American diet for 3 weeks duration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Viscous Fibre Blend | Dietary Supplement | High viscosity viscous fiber blend sprinkled on wheat and maize bran cereals(Bran Buds®; Kellogg Company) |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in LDL cholesterol | change from baseline after 21 days, relative to control |
| Measure | Description | Time Frame |
|---|---|---|
| change in total cholesterol | change from baseline after 21 days, relative to control | |
| change in triglycerides | change from baseline after 21 days, relative to control | |
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Inclusion Criteria:
-healthy individuals
Exclusion Criteria:
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| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D011620 | Psyllium |
| D004043 | Dietary Fiber |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| Psyllium | Dietary Supplement | Bran Buds cereal (white bran and maize bran) with psyllium (Bran Buds® with PSY; Kellogg Company) |
|
| Wheat Bran | Dietary Supplement | All Bran cereal (All Bran®; Kellogg Company) |
|
| change in HDL cholesterol |
| change from baseline after 21 days, relative to control |
| change in apolipoprotein B | change from baseline after 21 days, relative to control |
| change in apolipoprotein A-1 | change from baseline after 21 days, relative to control |
| D004040 |
| Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |