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Repetitive transcranial magnetic stimulation is a non-invasive neuromodulation technique used to treat different neuropsychiatric disorders, such as, depression, neuropathic pain, fibromyalgia and obsessive-compulsive disorder. It is known that the heart rate variability is altered in these conditions. Therefore the focus of this research is to show the influence of rTMS on the Heart Rate Variability.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| rTMS-PSI | Active Comparator | Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the posterior superior insula right. |
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| rTMS-M1 | Active Comparator | Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the right primary motor cortex. |
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| rTMS-F3 | Active Comparator | Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the left pre frontal dorsolateral cortex. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Repetitive transcranial magnetic stimulation | Procedure | Repetitive transcranial magnetic stimulation was a technique able to modulate the brain circuit restoring the function. |
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| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variability changes | Changes in heart rate variability measured by Polar V800 | Three times during the entire study. Following the scheme, Until 1 hour before each session, 15 minutes along the each session and until 1 hour after the end of session |
| Measure | Description | Time Frame |
|---|---|---|
| Conditioned Pain Modulation | change in pain units on a scale of 0-100. 0 no pain. 100 = the maximum pain | 48 hours before the first session of stimulation |
| Volume in | Determine if volume cortical regions can serve as biomarkers to predict rTMS treatment response in Healthy volunteers |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP) | São Paulo | São Paulo | 05403900 | Brazil |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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The participant will be received three different sessions of rtms, with wash out 30 days between sessions.
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| 1 week before the first session of stimulation |