Dexmedetomidine and Pregabalin for Conscious Sedation During Cataract Surgery

Dexmedetomidine With or Without Pregabalin Premedication for Conscious Sedation During Cataract Surgery Under Topical Anesthesia. A Randomized Double-blind Placebo-controlled Trial.

Although topical anesthesia by eye drops for cataract surgery is a non-invasive technique but it may provide insufficient anesthesia which requires the intraoperative use of additional topical local anesthetics and raises the need for sedation.

The present study is constructed to evaluate the effect of pregabalin on sedation using dexmedetomidine for cataract surgery under topical anesthesia . In the dexmedetomidine-pregabalin group, the patients will be premedicated by pregabalin. In the placebo group (control group) the patients will be premedicated by placebo capsules. All patients will be sedated by dexmedetomidine. Sedation will be assessed as a primary outcome measurement where pain, vital signs, intraoperative and postoperative pain, total analgesic needs and side effects will be assessed as secondary outcome measurements.

Inclusion Criteria:

• American Society Of Anesthesiologists (ASA) I and II physical status.
• Scheduled for cataract extraction under topical anesthesia.

Exclusion Criteria:

• Hepatic or renal impairment.
• Taking chronic psychotropic medications.
• Mental instability.
• Morbid obesity.
• Alcohol abuse.
• Substance abuse.
• Pregnant and lactating females.
• History of allergy to the study drugs used