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The aim of this research is to study the effect of a loading dose of colchicine on the occurrence of periprocedural myocardial infarction (PPMI) in elective percutaneous coronary intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Active Comparator | Stable coronary artery disease patients who have been assigned to elective PCI and who will be given standard of care treatment |
|
| Early colchicine loading dose | Active Comparator | Stable coronary artery disease patients who have been assigned to elective PCI and who will be given standard of care treatment plus colchicine loading dose 12-24 hours before PCI |
|
| Late colchicine loading dose | Active Comparator | Stable coronary artery disease patients who have been assigned to elective PCI and who will be given standard of care treatment plus colchicine loading dose one hour prior to PCI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Colchicine Loading Dose | Drug | Two milligrams of colchicine will be administrated in addition to the standard of care treatment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of PPMI post elective PCI | Occurrence of PPMI post elective PCI and its relation to defensin levels | 24 hours post PCI |
| Measure | Description | Time Frame |
|---|---|---|
| Traditional inflammatory markers | Determination of traditional inflammatory markers including c-reactive protein, white blood cells and interleukin-6 | 24 hours post PCI |
| Major adverse cardiovascular events |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rami Abu Fanne, MD, PhD | Contact | 972-50-3573694 | ramia@hadassah.org.il |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hille Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
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| Standard of care treatment prior to elective PCI | Drug | All medications normally given to patients prior to elective PCI |
|
Determining the occurrence of major adverse cardiovascular events
| 30 days |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D009336 | Necrosis |