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This study is aiming to evaluate clinically, radiographically ,and histologically GBR using collagen membrane in combination with a mixture of ABBM and autogenous particulated bone compared to collagen membrane with ABBM in atrophied anterior maxilla.
Guided bone regeneration (GBR) has been proposed as a possible alternative for patients with severe horizontal bone atrophy, to overcome the drawback of bone blocks techniques.6,8 To protect and prevent the invasion of the clot by nonosteogenic cells, maintaining an adequate biological space for the regeneration of bone tissue, the use of resorbable membranes, in combination with autologous or heterologous particulate bone have been proposed. Expanded polytetrafluoroethylene (e-PTFE) membranes are the most used non-resorbable membranes with the longest published follow-up, considering them the gold standard in the reconstructions of major horizontal bone defects. However, a second surgery is needed to remove them and they may get exposed in the oral cavity and contaminate with possible infection and graft loss. Conversely, the resorbable membranes most advantages are an ability to merge with the host tissues, as well as a rapid resorption in case of exposure, thereby reducing the risk of bacterial contamination. Resorbable membranes in combination with particulated anorganic bovine bone (ABB) can be used for the augmentation of horizontally deficient ridges. Particulated autogenous bone can be mixed with bone substitutes to add more osteogenic factors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GBR by xenograft | Placebo Comparator |
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| GBR by xenograft ,autogenous bone | Active Comparator | Intervention In the control group:first crestal incision then two vertical incisions by blade 15c,full thickness flap reflection, bone decortication will be done using surgical round bur, autogenous bone will be harvested by trephine bur ,mixed 1:1 with anorganic bovine bone derived mineral and packed at the defected area(atrophic maxilla) then covered by a native collagen membrane which will be stabilized by tacks.Then The flap will then be closed using interrupted 4/0 resorbable sutures. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GBR by xenograft and autogenous bone | Procedure | Ridge augmentation by native collagen membrane and mix of anorganic bovine bone derived mineral with particulated autogenous bone chips (ratio 1:1). |
| Measure | Description | Time Frame |
|---|---|---|
| Height and width of bone gained | Height and width of bone gained in mm by CBCT | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Bone area percentage | Bone area percentage % by Histo-morphometric analysis | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
• Heavy smokers more than 20 cigarettes per day.(32)
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hossam Elbaha, Master | Contact | +201277750002 | hossam_elbaha@yahoo.com | |
| hossam Elbaha | Contact |
| Name | Affiliation | Role |
|---|---|---|
| hossam Elbaha | Cairo University | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27283920 | Result | Meloni SM, Jovanovic SA, Urban I, Canullo L, Pisano M, Tallarico M. Horizontal Ridge Augmentation using GBR with a Native Collagen Membrane and 1:1 Ratio of Particulated Xenograft and Autologous Bone: A 1-Year Prospective Clinical Study. Clin Implant Dent Relat Res. 2017 Feb;19(1):38-45. doi: 10.1111/cid.12429. Epub 2016 Jun 9. |
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| ID | Type | URL | Comment |
|---|---|---|---|
| Study Protocol | View IPD |
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The patients will be randomly divided into 2 equal groups
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Each patient will be given a code by the researcher and the observers will be blind to which group this case belong.