The Water-based Exercise Group will compromise participants attending a 2 weekly exercise intervention each session lasting 1 hour for 12 weeks.

Each session will consist of:

• 10 minutes of warm-up: general mobilisation, walking, active stretching
• 40 minutes of global training: 20 minutes of endurance exercise and 20 minutes of resistance exercises targeting large main muscle groups involved in daily life activities (squats, lateral hip abduction, row, etc.) using body weight and elastic bands
• 10 minutes of cooling down: stretching, breathing exercises and relaxation Intensity will be monitored with the modified Borg Scale to maintain a 5 - 6 level of exertion during the first 5 weeks and progressively increase to a 6 - 7 level for the following weeks.

The land-based exercise group will attend as well 2 weekly sessions lasting 1 hour each for 12 weeks.

Each session will consist of the same structure as the Water-based Exercise Group including:

• 10 minutes warm up
• 40 minutes of global training (20 minutes of endurance exercise and 20 minutes of resistance training)
• 10 minutes cool down. The exercises will be adapted from the water-based exercise group to match the requirements on the water-based exercise group. Intensity will be monitored with the Perceived Rate of Exertion Scale (modified Borg Scale, Borg 1982) to maintain a 5 - 6 level of exertion during the first 5 weeks and progressively increase to a 6 - 7 level for the following weeks.

The intervention consist will of a water-based exercise protocol

Cancer-related fatigue as measure with the specific subscale found in the EORTC QLQ C30 questionnaire specifically designed for a cancer population

6 Minute Walk Test performed accordingly to international guidelines