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| Name | Class |
|---|---|
| University of Helsinki | OTHER |
| University of Eastern Finland | OTHER |
| Turku University Hospital | OTHER_GOV |
| Academy of Finland |
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Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise intervention | Experimental | Six months of exercise training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise training | Behavioral | Subjects are required to exercise four times a week during six months. Exercise training consists of endurance training, resistance training and high-intensity interval training adjusted to subject's fitness level. |
| Measure | Description | Time Frame |
|---|---|---|
| Effects of exercise training - brain glucose uptake | Brain glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with [18F]-labelled fluoro-deoxy-glucose (FDG) tracer. | The change from baseline to 6 months |
| Effects of exercise training - brain inflammation | Brain inflammation (dimensionless; standistibution volume ratio) is measured with positron emission tomography (PET) with PK11195 tracer | The change from baseline to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Effects of exercise training - liver glucose uptake | Liver glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with [18F]-labelled fluoro-deoxy-glucose (FDG) tracer | The change from baseline to 6 months |
| Effects of exercise training - adipose tissue glucose uptake |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jarna Hannukainen, PhD | Turku PET Cente, University of Turku, Finland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Turku | Turku | 20540 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33627179 | Derived | Heiskanen MA, Honkala SM, Hentila J, Ojala R, Lautamaki R, Koskensalo K, Lietzen MS, Saunavaara V, Saunavaara J, Helmio M, Loyttyniemi E, Nummenmaa L, Collado MC, Malm T, Lahti L, Pietilainen KH, Kaprio J, Rinne JO, Hannukainen JC. Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight. BMC Sports Sci Med Rehabil. 2021 Feb 24;13(1):16. doi: 10.1186/s13102-021-00241-z. |
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IPD of the main outcome measures will be opened if possible to such as extent that individuals cannot be identified.
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| OTHER |
| Finnish Cultural Foundation | OTHER |
| Diabetes Research Foundation, Finland | OTHER |
| Juho Vainio Foundation | OTHER |
Exercise Training for six months
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Adipose tissue glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with [18F]-labelled fluoro-deoxy-glucose (FDG) tracer |
| The change from baseline to 6 months |
| Effects of exercise training - whole-body insulin sensitivity | Whole-body insulin sensitivity (M-value; micromol/100g/min) during the hyperinsulinemic euglycemic clamp | The change from baseline to 6 months |
| Effects of exercise training - ectopic fat | Ectopic fat content (%) is measured using magnetic resonance spectroscopy (MRS) | The change from baseline to 6 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |