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| Name | Class |
|---|---|
| South-Eastern Norway Regional Health Authority | OTHER |
| University of Oslo | OTHER |
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Chronic kidney disease (CKD) is highly frequent, and patients with advanced CKD are known to have a high risk of developing cardiovascular disease (CVD). However, little is known about the cardiovascular risk in patients with mildly reduced kidney function (reduced glomerular filtration rate, GFR), affecting up to 10% of the general population; and importantly, also affecting living kidney donors. Until recently it has been believed that donating a kidney does not represent any health hazard. However, a recent Norwegian epidemiological study suggested that kidney donors have an increased risk of CVD. The pathogenesis linking reduced kidney function to CVD is not known. Living kidney donors provide a unique model for investigating the mechanisms underlying increased risk of CVD in patients with reduced GFR because living kidney donors are healthy before donation. Thus, the main purpose of the Project is to investigate the mekanismes underlying the development of cardiovascular remodelling induced by a reduction in GFR.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kidney Donors |
| ||
| Control group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nephrectomy | Procedure | Unilateral nephrectomy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in left ventricular mass. | Cardiac magnetic resonance imaging (CMRI) and echocardiography. | Before kidney donation (between one month and 1 day before surgery), new investigation 2,5, 5 and 10 years after kidney donation. |
| Change in left ventricular strain. | CMRI and echocardiography. | Before kidney donation (between one month and 1 day before surgery), new investigation 2,5, 5 and 10 years after kidney donation. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in arterial pulse wave velocity. | CMRI | Before kidney donation (between one month and 1 day before surgery), new investigation 2,5, 5 and 10 years after kidney donation. |
| Change in intima and media thickness of aorta. |
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Exclusion Criteria:
• Persons who do not meet the Norwegian donor criteria.
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The project is a prospective longitudinal parallel group study including persons selected as living kidney donors according to the Norwegian donor criteria and accepted for surgery at Rikshospitalet, Norway. The donors will be compared to a control group consisting of individuals evaluated for donation, but not found eligible and healthy family members related to donors. The control individuals will be age and sex matched to living kidney donors. Control individuals who accept to participate will go through the same test battery (the Norwegian transplantation protocol for living kidney donors) as living kidney donors and must fulfil these criteria before inclusion as controls.
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| Name | Affiliation | Role |
|---|---|---|
| Jon Arne Birkeland, MD, PhD | Oslo University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital | Oslo | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38606688 | Derived | Brobak KM, Halvorsen LV, Aass HCD, Soraas CL, Aune A, Olsen E, Bergland OU, Rognstad S, Blom KB, Birkeland JAK, Hoieggen A, Larstorp ACK, Solbu MD. Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage. Blood Press. 2024 Dec;33(1):2323980. doi: 10.1080/08037051.2024.2323980. Epub 2024 Apr 12. | |
| 31718316 |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D009392 | Nephrectomy |
| ID | Term |
|---|---|
| D013520 | Urologic Surgical Procedures |
| D013519 | Urogenital Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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CMRI Inflammation: biomarkers.
| Before kidney donation (between one month and 1 day before surgery), new investigation 2,5, 5 and 10 years after kidney donation. |
| Change in the calsium/phosphate homeostasis. | DXA-scan. | Before kidney donation (between one month and 1 day before surgery), new investigation 2,5, 5 and 10 years after kidney donation. |
| Change in inflammation-marker. | Biomarker: high sensitive CRP | Before kidney donation (between one month and 1 day before surgery), new investigation 2,5, 5 and 10 years after kidney donation. |
| Blom KB, Bergo KK, Espe EKS, Rosseland V, Grotta OJ, Mjoen G, Asberg A, Bergan S, Sanner H, Bergersen TK, Bjornerheim R, Skauby M, Seljeflot I, Waldum-Grevbo B, Dahle DO, Sjaastad I, Birkeland JA. Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study. Blood Press. 2020 Apr;29(2):123-134. doi: 10.1080/08037051.2019.1684817. Epub 2019 Nov 13. |