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Embryo Transfer With Self-spent Culture Medium or new Culture Medium in Vitro Fertilization - Embryo Transfer Process, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the two?
Although some metabolites are present in self-spent culture medium, there are some embryonic exocrine factors secreted by embryo.These factors may have a positive impact on embryo implantation and subsequent development. So it is necessary to compare the two ways of embryo transfer with Self-spent Culture Medium or New Culture Medium in vitro fertilization - embryo transfer process.
The purpose of this study is to analyze which way can improve clinical pregnancy and birth outcomes, is there a significant difference between the two?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Self-spent Culture Medium | Experimental | Changing embryo transfer solution with self-spent culture medium |
|
| New Culture Medium | No Intervention | embryo transfer with new culture medium in IVF-ET |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Self-spent Culture Medium | Procedure | Replace embryo transfer solution with Self-spent culture medium in IVF-ET. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants Pregnant After 4 Weeks | Observe the clinical pregnancy rate under different embryo transfer methods | 4 weeks |
| Live Birth | Observe the live birth rate under different embryo transfer methods | 40 weeks |
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Inclusion Criteria:
Exclusion Criteria:
Women in childbearing age intend to do IVF
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| Name | Affiliation | Role |
|---|---|---|
| Yingchun zhang, Dr | Jinan Central Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jinan Central Hospital Affiliated to Shandong University | Jinan | Shandong | 250013 | China |
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| ID | Title | Description |
|---|---|---|
| FG000 | Self-spent Culture Medium | Changing embryo transfer solution with self-spent culture medium Self-spent Culture Medium: Replace embryo transfer solution with Self-spent culture medium in IVF-ET. |
| FG001 | New Culture Medium | embryo transfer with new culture medium in IVF-ET |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Self-spent Culture Medium | Changing embryo transfer solution with self-spent culture medium Self-spent Culture Medium: Replace embryo transfer solution with Self-spent culture medium in IVF-ET. |
| BG001 | New Culture Medium |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Participants Pregnant After 4 Weeks | Observe the clinical pregnancy rate under different embryo transfer methods | Posted | Count of Participants | Participants | 4 weeks |
|
1 year
No any abnormal sign (for example, abnormal physical exam or laboratory finding), symptom, or disease, temporally associated with the participant's participation in the research,
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Self-spent Culture Medium | embryo transfer with self-spent culture medium | 0 |
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Studies of larger sample sizes and studies on some other variables were needed to be further performed.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. bin wu | Reproductive medcine of Jinan central hospatil | +86 053185695203 | wb0538@163.com |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Dec 1, 2019 | Dec 31, 2019 | Prot_SAP_000.pdf |
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embryo transfer with new culture medium in IVF-ET
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants | No |
|
| duration of infertility | Mean | Standard Deviation | years |
|
| Units |
|---|
| Counts |
|---|
| Participants |
|
|
| Primary | Live Birth | Observe the live birth rate under different embryo transfer methods | Posted | Count of Participants | Participants | 40 weeks |
|
|
|
| 150 |
| 0 |
| 150 |
| 0 |
| 150 |
| EG001 | New Culture Medium | embryo transfer with new culture medium | 0 | 168 | 0 | 168 | 0 | 168 |
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