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Aim of this prospective study is to assess the pathophysiology of Takotsubo Syndrome by obtaining pressure volume loops with conductance catheters, which allows detailed conclusions regarding systolic and diastolic hemondynamics and subsequently regarding potential underlying mechanisms
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental intervention | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurements of left ventricular pressure and volume | Diagnostic Test | Patients with suspected Takotsubo syndrome (typical ballooning in left ventriculography without significant obstructive coronary artery disease that sufficiently explains the contraction abnormalities) will undergo continuous online measurements of left ventricular pressure and volume using conductance catheters. Cardiac magnetic resonance (CMR) imaging will be performed in patients without contraindications for optimized morphological characterization and exclusion of important differential diagnoses. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in contractility derived from pressure-volume measurements | systolic/diastolic pressure-volume relationship (mmHg/ml) | Day 0 |
| Changes in contractility derived from pressure-volume measurements | peak-power index (mmHG/s) | Day 0 |
| Changes in contractility derived from pressure-volume measurements | peak filling rate (ml/s) | Day 0 |
| Changes in contractility derived from pressure-volume measurements | stroke work (mmHG x ml) | Day 0 |
| Changes in contractility derived from pressure-volume measurements | relaxation constant "Tau" (ms) | Day 0 |
| Changes in contractility derived from pressure-volume measurements | time to Emax (ms) | Day 0 |
| Changes in contractility derived from pressure-volume measurements | max/min rate of left ventricular pressure change (mmHg/s) | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Energetic parameters derived from pressure-volume measurements | stroke work, potential energy (mmHg x ml) | Day 0 |
| Energetic parameters derived from pressure-volume measurements | total pressure volume area (mmHg/ml) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical clinic II-UKSH | Lübeck | Schleswig-Holstein | 23562 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37197841 | Derived | Stiermaier T, Reil JC, Sequeira V, Rawish E, Mezger M, Patz T, Paitazoglou C, Schmidt T, Frerker C, Steendijk P, Reil GH, Eitel I. Hemodynamic Assessment in Takotsubo Syndrome. J Am Coll Cardiol. 2023 May 23;81(20):1979-1991. doi: 10.1016/j.jacc.2023.03.398. |
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| ID | Term |
|---|---|
| D054549 | Takotsubo Cardiomyopathy |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D018487 | Ventricular Dysfunction, Left |
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|
| Day 0 |
| Afterload parameters derived from pressure-volume measurements | arterial elastance (mmHg/ml) | Day 0 |
| Afterload parameters derived from pressure-volume measurements | ventricular arterial coupling (no dimension) | Day 0 |
| Afterload parameters derived from pressure-volume measurements | total arterial compliance (mmHg/ml) | Day 0 |
| - Correlation of pressure-volume measurements with morphological and functional findings in CMR imaging | (presence of myocardial edema or late gadolinium enhancement, native T1 time, myocardial strain assessed by CMR feature tracking) | Day 3 |
| - Correlation of pressure-volume measurements with biomarker release | (troponin, NT-proBNP) | Day 0 |
| D018754 |
| Ventricular Dysfunction |