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To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance
Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy individuals (camel milk) | Experimental |
| |
| Healthy individuals (cow milk) | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Camel milk | Dietary Supplement | Camel Milk administered 10 minutes before a mixed meal of carbohydrate and protein; 2-week washout between interventions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose response to camel and cow milk | The difference between interventions in terms of peak of glucose | 5 months |
| Response of glucose to camel and cow milk | The difference between interventions in terms of area under the curve | 5 months |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin response to camel and cow milk | The difference between interventions in terms of peak | 5 months |
| Response of insulin to camel and cow milk | The difference between interventions in terms of area under the curve |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dr Nader Lessan, MBBS MD FRCP | Imperial College London Diabetes Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Imperial College London Diabetes Centre | Recruiting | Abu Dhabi | 48338 | United Arab Emirates |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D008892 | Milk |
| ID | Term |
|---|---|
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
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Double-blind
| Cow milk | Dietary Supplement | Cow milk administered 10 minutes before a mixed meal of carbohydrate and protein;2-week washout between interventions |
|
| 5 months |
| GLP-1 response to camel and cow milk | The difference between interventions in terms of peak | 5 months |
| Response of GLP-1 to camel and cow milk | The difference between interventions in terms of area under the curve | 5 months |
| C-peptide response to camel and cow milk | The difference between interventions in terms of peak | 5 months |
| Response of C-peptide to camel and cow milk | The difference between interventions in terms of area under the curve | 5 months |
| D005502 |
| Food |
| D019602 | Food and Beverages |