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Obesity is associated with low testosterone in men and with dyslipidemia. Adropin hormone is negatively correlated with body mass index and is associated with dyslipidemia.
correlation between adropin and testosterone will be evaluated.
Obesity, a worldwide epidemic is associated with multiple adverse health outcome as diabetes mellitus, hypertension and cardiovascular diseases caused mainly by dyslipidemia linked to obesity. Low testosterone levels in obese men were found associated with dyslipidemia.
Adropin is a new metabolic hormone that was first isolated in liver and brain tissues, It was observed that mice fed on a high-fat diet (HFD) had a rapid increase in adropin expression compared to control values. In human also, adropin levels were negatively correlated with body mass index (BMI) and were associated with dyslipidemia.
Adiponectin is a protein that is mainly produced by white adipose tissue and has an important role in lipid metabolism. Serum adiponectin concentrations were decreased in obese compared to normal weight men and significantly correlated with testosterone level.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| obese men | Adult obese men (BMI ≥ 30 kg/m2) |
| |
| normal men | normal weight men (18.5 ≤ BMI < 25 kg/m2 ) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL)) | Diagnostic Test | blood samples will be collected after 10 hours fasting |
| Measure | Description | Time Frame |
|---|---|---|
| changes in lipid profile (TC, TG, LDL, HDL) levels | expected higher TC, TG, LDl levels and lower HDL levels in obese men compared to normal | 6 months |
| changes in total testosterone levels | expected lower testosterone levels in obese men compared to normal men | 6 months |
| changes in adropin level | expected lower adropin levels in obese men compared to normal men | 6 months |
| changed in adiponectin levels | expected lower adiponectin level in obese men compared to normal men | 6 months |
| correlation between adropin and testosterone | 6 months | |
| correlation between adropin and adiponectin | 6 months |
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Inclusion Criteria:
Age from 18 years to 50 years. Clinically free except from obesity
Exclusion Criteria:
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obese and normal weight men from 18 years to 50 years
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| Name | Affiliation | Role |
|---|---|---|
| Asmaa Abdelmageed Muhammed, Assistant lecturer | Aswan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aswan University Hospital | Aswān | 81528 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28295504 | Background | Canguven O, Talib RA, El Ansari W, Yassin DJ, Salman M, Al-Ansari A. Testosterone therapy has positive effects on anthropometric measures, metabolic syndrome components (obesity, lipid profile, Diabetes Mellitus control), blood indices, liver enzymes, and prostate health indicators in elderly hypogonadal men. Andrologia. 2017 Dec;49(10). doi: 10.1111/and.12768. Epub 2017 Mar 10. | |
| 29331507 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050171 | Dyslipidemias |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Total testosterone | Diagnostic Test | blood samples will be collected after 10 hours fasting |
|
| Adropin | Diagnostic Test | blood samples will be collected after 10 hours fasting |
|
| Adiponectin | Diagnostic Test | blood samples will be collected after 10 hours fasting |
|
| Background |
| Ghoshal S, Stevens JR, Billon C, Girardet C, Sitaula S, Leon AS, Rao DC, Skinner JS, Rankinen T, Bouchard C, Nunez MV, Stanhope KL, Howatt DA, Daugherty A, Zhang J, Schuelke M, Weiss EP, Coffey AR, Bennett BJ, Sethupathy P, Burris TP, Havel PJ, Butler AA. Adropin: An endocrine link between the biological clock and cholesterol homeostasis. Mol Metab. 2018 Feb;8:51-64. doi: 10.1016/j.molmet.2017.12.002. Epub 2017 Dec 30. |
| 27550773 | Background | Yosaee S, Khodadost M, Esteghamati A, Speakman JR, Shidfar F, Nazari MN, Bitarafan V, Djafarian K. Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects. Am J Mens Health. 2017 Mar;11(2):426-434. doi: 10.1177/1557988316664074. Epub 2016 Aug 22. |
| 26139044 | Background | Kim AY, Park YJ, Pan X, Shin KC, Kwak SH, Bassas AF, Sallam RM, Park KS, Alfadda AA, Xu A, Kim JB. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun. 2015 Jul 3;6:7585. doi: 10.1038/ncomms8585. |
| 23375204 | Background | Thomas S, Kratzsch D, Schaab M, Scholz M, Grunewald S, Thiery J, Paasch U, Kratzsch J. Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa. Fertil Steril. 2013 Apr;99(5):1256-1263.e3. doi: 10.1016/j.fertnstert.2012.12.022. Epub 2013 Jan 30. |
| 35897011 | Derived | Muhammed AA, Eid RMHM, Mohammed WS, Abdel-Fadeil MR. An association between adropin hormone and total testosterone in obese men: a case-control study. BMC Endocr Disord. 2022 Jul 27;22(1):192. doi: 10.1186/s12902-022-01102-7. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |