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| Name | Class |
|---|---|
| Peking Union Medical College Hospital | OTHER |
| General Hospital of Chinese Armed Police Forces | OTHER |
| General Hospital of Shenyang Military Region | OTHER |
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A prospective, multicenter, cohort study to explore the stroke mechanisms of symptomatic intracranial atherosclerosis, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus high-resolution magnetic resonance (HR-MRI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intracranial Atherosclerosis | First-ever stroke patients attributed to intracranial artery stenosis (> 50% or occlusion) who receive aggressive medical management |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aggressive medical management | Drug | Aspirin (100 mg daily) and Clopidogrel (75 mg daily) for 3 months and Rosuvastatin (20mg daily) for at least 6 months as well as traditional risk factors management |
| Measure | Description | Time Frame |
|---|---|---|
| poor functional outcome | The Rankin Score runs from 0-6, running from perfect health without symptoms to death. mRS 0-2 are defined as favorable outcomes while mRS 3-6 as unfavorable outcomes.0 - No symptoms.1 - No significant disability. Able to carry out all usual activities, despite some symptoms.2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.3 - Moderate disability. Requires some help, but able to walk unassisted.4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent.6 - Dead. | 90 day after stroke onset |
| Number of Participants with stroke recurrence | stroke recurrence with new lesions on DWI | 12 months after stroke onset |
| Evolution of intracranial atherosclerosis burden | Changes of plaque and thrombus volume on HR-MRI images at the admission and the follow-up | 6 months after stroke onset |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with Death due to Heart Disease, Cerebravascular Disease or Other Vascular Etiology | death due to stroke, intracranial hemorrhage,heart attack,heart failure, arrhythmia,pulmonary embolism,visceral hemorrhage or other vascular etiology | 12 months after stroke onset |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with Adverse Events That Are Related to Anti-platelet Treatment | intracranial bleeding confirmed by CT，fatal bleeding causing hemodynamic abnormalities needed blood tranfusion or surgical intervention | 12 months after stroke onset |
| Number of Participants with Adverse Events That Are Related to StatinTreatment |
Inclusion Criteria:
Exclusion Criteria:
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hospital based population
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Weihai Xu, MD | Contact | 010-69156114 | xuwh@pumch.cn | |
| Yining Huang, MD | Contact | ynhuang@sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Weihai Xu, MD | Peking Union Medical College Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Hospital | Recruiting | Beijing | Beijing Municipality | 100010 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19041971 | Background | Li ML, Xu WH, Song L, Feng F, You H, Ni J, Gao S, Cui LY, Jin ZY. Atherosclerosis of middle cerebral artery: evaluation with high-resolution MR imaging at 3T. Atherosclerosis. 2009 Jun;204(2):447-52. doi: 10.1016/j.atherosclerosis.2008.10.019. Epub 2008 Oct 25. | |
| 18309170 | Background | Mazighi M, Labreuche J, Gongora-Rivera F, Duyckaerts C, Hauw JJ, Amarenco P. Autopsy prevalence of intracranial atherosclerosis in patients with fatal stroke. Stroke. 2008 Apr;39(4):1142-7. doi: 10.1161/STROKEAHA.107.496513. Epub 2008 Feb 28. |
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| Subei People's Hospital of Jiangsu Province |
| OTHER |
| Fujian Medical University Union Hospital | OTHER |
| Tangshan Gongren Hospital | OTHER |
| Third Affiliated Hospital, Sun Yat-Sen University | OTHER |
| Qingdao Municipal Hospital | OTHER |
| West China Hospital | OTHER |
| Shanghai Tong Ren Hospital | OTHER |
| Ruijin Hospital | OTHER |
| The First Affiliated Hospital of University of South China | OTHER |
| JiNing NO.1 People Hospital | UNKNOWN |
| Tongji Hospital | OTHER |
| The University of Hong Kong-Shenzhen Hospital | OTHER |
| Beijing Anzhen Hospital | OTHER |
| Beijing Hospital | OTHER_GOV |
| Peking University International Hospital | OTHER |
| Beijing Tongren Hospital | OTHER |
| China-Japan Friendship Hospital | OTHER |
| Peking University First Hospital | OTHER |
| Beijing Friendship Hospital | OTHER |
| Beijing Chao Yang Hospital | OTHER |
| Qilu Hospital of Shandong University (Qingdao) | OTHER |
| Shandong Provincial Hospital | OTHER_GOV |
| The Second Hospital of Hebei Medical University | OTHER |
| Hebei General Hospital | OTHER |
| First Affiliated Hospital of Zhejiang University | OTHER |
| China-Japan Union Hospital, Jilin University | OTHER |
| Zhejiang Provincial Tongde Hospital | OTHER |
| People's Hospital of Ningxia Hui Autonomous Region | OTHER |
| Taiyuan Central Hospital of Shanxi Medical University | OTHER |
| Hong Xinglong Central Hospital | UNKNOWN |
| Changzhi People's Hospital | OTHER |
| Weihai Municipal Hospital | OTHER |
| Southwest Hospital, China | OTHER |
| Affiliated Taihe Hospital of Hubei University of Medicine | UNKNOWN |
| Nanshi Hospital of Nanyang | UNKNOWN |
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|
more than 3-fold liver enzyme increase，rhabdomyolysis |
| 12 months after stroke onset |
| Beijing Tongren Hospital Capital Medical University | Not yet recruiting | Beijing | Beijing Municipality | 100010 | China |
|
| Beijing Anzhen Hospital Capital Medical University | Recruiting | Beijing | Beijing Municipality | 100020 | China |
|
| Beijing Chao-Yang hospital | Not yet recruiting | Beijing | Beijing Municipality | 100020 | China |
|
| China-Japan Friendship Hospital | Not yet recruiting | Beijing | Beijing Municipality | 100020 | China |
|
| Beijing Friendship Hospital Capital Medical University | Not yet recruiting | Beijing | Beijing Municipality | 100032 | China |
|
| Peking University First Hospital | Not yet recruiting | Beijing | Beijing Municipality | 100032 | China |
|
| General Hospital of Chinese Armed Police Forces | Recruiting | Beijing | Beijing Municipality | 100039 | China |
|
| Peking Union Medical College Hospital | Recruiting | Beijing | Beijing Municipality | 100730 | China |
|
| Peking University International Hospital | Not yet recruiting | Beijing | Beijing Municipality | 102200 | China |
|
| The first affiliated hospital affiliated to AMU (Southwest Hospital) | Not yet recruiting | Chongqing | Chongqing Municipality | China |
|
| Fujian Medical University Union Hospital | Recruiting | Fuzhou | Fujian | 350001 | China |
|
| The Third Affiliated Hospital of Sun Yat-sen University | Not yet recruiting | Guangzhou | Guangdong | 510630 | China |
|
| The University of HongKong-Shenzhen Hospital | Not yet recruiting | Shenzhen | Guangdong | 518000 | China |
|
| Hebei General Hospital | Recruiting | Shijiazhuang | Hebei | China |
|
| The Second Hospital of Hebei Medical University | Recruiting | Shijiazhuang | Hebei | China |
|
| Tangshan Gongren Hospital | Recruiting | Tangshan | Hebei | 063000 | China |
|
| Hong Xinglong Central Hospital | Recruiting | Shuangyashan | Heilongjiang | China |
|
| Nanshi Hospital of Nanyang | Not yet recruiting | Nanyang | Henan | China |
|
| Affiliated Taihe Hospital of Hubei University of Medicine | Not yet recruiting | Shiyan | Hubei | China |
|
| Tongji Hospital, Huazhong University of Science and Technology | Recruiting | Wuhan | Hubei | 430000 | China |
|
| The First Affiliated Hospital of University of South China | Active, not recruiting | Hengyang | Hunan | Hunan | China |
| Subei People's Hospital of Jiangsu Province | Recruiting | Yangzhou | Jiangsu | 225001 | China |
|
| China-Japan Union Hospital, Jilin University | Recruiting | Changchun | Jilin | China |
|
| General Hospital of Shen Yang Millitary Command | Not yet recruiting | Shenyang | Liaoning | 110840 | China |
|
| People's Hospital Ningxia Hui Autonomous Region | Recruiting | Yinchuan | Ningxia | China |
|
| Shandong Provincial Hospital | Active, not recruiting | Jinan | Shandong | China |
| JiNing NO.1 People Hospital | Recruiting | Jining | Shandong | 272000 | China |
|
| Qingdao Municipal Hospital | Not yet recruiting | Qingdao | Shandong | 266000 | China |
|
| Qilu Hospital of Shandong University (Qingdao) | Not yet recruiting | Qingdao | Shandong | 266555 | China |
|
| Weihai Municipal Hospital | Not yet recruiting | Weihai | Shandong | China |
|
| Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine | Not yet recruiting | Shanghai | Shanghai Municipality | 200050 | China |
|
| Tongren Hospital, Shanghai Jiaotong University School of Medicine | Recruiting | Shanghai | Shanghai Municipality | 200050 | China |
|
| Changzhi People's Hospital | Not yet recruiting | Changzhi | Shanxi | China |
|
| Taiyuan Central Hospital of Shanxi Meidical University | Not yet recruiting | Taiyuan | Shanxi | China |
|
| West China Hospital of Sichuan University | Recruiting | Chengdu | Sichuan | 610000 | China |
|
| First Affiliated Hospital of Zhejiang University | Recruiting | Hangzhou | Zhejiang | China |
|
| Zhejiang Provincial Tongde Hospital | Not yet recruiting | Hangzhou | Zhejiang | China |
|
| 20638663 | Background | Xu WH, Li ML, Gao S, Ni J, Zhou LX, Yao M, Peng B, Feng F, Jin ZY, Cui LY. In vivo high-resolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis. Atherosclerosis. 2010 Oct;212(2):507-11. doi: 10.1016/j.atherosclerosis.2010.06.035. Epub 2010 Jun 25. |
| 21799160 | Background | Xu WH, Li ML, Gao S, Ni J, Zhou LX, Yao M, Peng B, Feng F, Jin ZY, Cui LY. Plaque distribution of stenotic middle cerebral artery and its clinical relevance. Stroke. 2011 Oct;42(10):2957-9. doi: 10.1161/STROKEAHA.111.618132. Epub 2011 Jul 28. |
| 22367991 | Background | Xu WH, Li ML, Gao S, Ni J, Yao M, Zhou LX, Peng B, Feng F, Jin ZY, Cui LY. Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance. Ann Neurol. 2012 Feb;71(2):195-8. doi: 10.1002/ana.22626. |
| 24423003 | Background | Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S. Intracranial artery atherosclerosis and lumen dilation in cerebral small-vessel diseases: a high-resolution MRI Study. CNS Neurosci Ther. 2014 Apr;20(4):364-7. doi: 10.1111/cns.12224. Epub 2014 Jan 15. |
| 24530171 | Background | Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S. Deep tiny flow voids along middle cerebral artery atherosclerotic occlusions: a high-resolution MR imaging study. J Neurol Sci. 2014 Apr 15;339(1-2):130-3. doi: 10.1016/j.jns.2014.01.042. Epub 2014 Feb 6. |
| 25666631 | Background | Li M, Wu SW, Xu WH. High-resolution MRI of radiation-induced intracranial vasculopathy. Neurology. 2015 Feb 10;84(6):631. doi: 10.1212/WNL.0000000000001223. No abstract available. |
| 24168957 | Background | Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Lancet. 2014 Jan 25;383(9914):333-41. doi: 10.1016/S0140-6736(13)62038-3. Epub 2013 Oct 26. |
| 27164677 | Background | Xu YY, Li ML, Gao S, Hou B, Sun ZY, Zhou HL, Feng F, Xu WH. Non-moyamoya vessel network formation along steno-occlusive middle cerebral artery. Neurology. 2016 May 24;86(21):1957-63. doi: 10.1212/WNL.0000000000002698. Epub 2016 Apr 27. |
| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| D000077144 | Clopidogrel |
| D000068718 | Rosuvastatin Calcium |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013988 | Ticlopidine |
| D058924 | Thienopyridines |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D013449 | Sulfonamides |
| D000577 | Amides |
| D005464 | Fluorobenzenes |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D013450 | Sulfones |
| D011743 | Pyrimidines |
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