Effect of Theophylline in Pseudohypoparathyroidism

Effect of Theophylline in Pseudohypoparathyroidism

The study evaluates the effect of theophylline in 100 subjects with Pseudohypoparathyroidism.

It is an open label intervention study for the off-label use of theophylline in psuedohypoparathyroidism (PHP).Theophylline is a is non-specific phosphodiesterase inhibitor which increases the levels of secondary messenger,cAMP. PHP patients have end organ resistance to hormones involving cAMP signaling. Thus, theophylline has a potential to abrogate hormone resistance. Also, it may have a role in bone maturation, neurocognition and metabolism.

Inclusion Criteria:

• Subjects with known diagnosis of PHP1A and PHP1B
• Age >5 years

Exclusion Criteria:

• • Significant kidney disease, i.e. any CKD stage

  • Hypercalciuria
  • Kidney stones
  • Severe Heart disease
  • Uncontrolled seizure disorder
  • Peptic ulcer
  • Liver dysfunction
  • Bleeding disorder
  • Allergy to theophylline preparation
  • Muscle disorder
  • Infection
  • Any neurologic disease
  • Chronic drugs interacting with theophylline