Graft failure is a lethal complication after allogeneic stem cell transplantation, which often need a salvage transplantation. However, the current outcome of second transplantation for graft failure is far from satisfactory. We performed a prospective single-arm study to investigate the safety and efficacy of a novel regimen.

Inclusion Criteria:

• graft failure after first allogeneic stem cell transplantation
• no active infection or GVHD or severe organ dysfunction
• sign written informed consent

Exclusion Criteria:

• active infection, GVHD, organ failure
• expected life < 28 days