Single-arm, feasibility study to evaluate the Ceragenin Coated Endotracheal Tube (the CeraShield ETT) in adults who require intubation and are expected to be mechanically ventilated for ≥ 24 hours.

Inclusion Criteria:

• Age of 18 years or older;
• Patients requiring a 7.0mm, 7.5mm, 8.0mm or 8.5mm endotracheal tube;
• Expected to be mechanically ventilated for ≥24 hours.

Exclusion Criteria:

• Currently participating in another clinical trial which conflicts with this trial's design.
• Patients with a pre-existing respiratory infection, i.e., pneumonia.
• Patients with pulmonary contusions.
• Patients with cystic fibrosis.
• Patients demonstrating symptoms of bronchiectasis.
• Patients demonstrating symptoms of severe or massive hemoptysis. Severe or massive hemoptysis defined as greater than 500 ml of blood per day, or greater than 200 ml in six hours.
• Patients who have been intubated within the last 30 days requiring reintubation.
• Women of child-bearing potential who have not undergone a pregnancy test will be excluded from the study.
• Patient is pregnant.