Carbetocin on Myocardial Repolarization Dynamics in Obstetrics Study

The Effect of Carbetocin Dose on Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia

Relationship between carbetocin dose on transmural dispersion of repolarization (TDR).

Carbetocin is a uterotonic used to prevent postpartum hemorrhage. Although it has been proven to be completely safe, little is known about its effects on the electrical activity of the heart. The investigators aim to determine its effect on myocardial repolarization dynamics

Inclusion Criteria:

• Pregnant patients ≥ 36 weeks gestation, for elective Cesarean delivery under neuraxial anesthesia
• American Society of Anesthesiologists (ASA) class 2
• Patients ≥ 19 years of age

Exclusion Criteria:

• Long QT syndrome
• Cardiac disease or rhythm abnormalities
• Family history of long QT syndrome or abnormal cardiac conduction
• Currently taking medication that is known to prolong the QT interval
• Women who are high risk for uterine atony as outlined in SOGC
• Known allergic reaction or hypersensitivity to Carbetocin or any other oxytocin homologue
• Patients who are unable to give informed consent because of a language barrier as the study team only speaks English and will be unable to complete consent process and study procedure appropriately.