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This study aims to examine the effects of transcranial direct current stimulation at corticobulbar excitability in individuals with different gene polymorphism.
The effects of TDCS on corticobulbar excitability of the brain after inhibitory pre-conditioning will be compared in patients with different BDNF phenotypes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy | Healthy adults - Participants will receive single session of tdcs after application |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tdcs | Device | application of optimised parameters of tDCS (anodal stimulation, 1.5 mA, 10 min) over the unconditioned hemisphere reverses the brain and behavioural consequences of inhibitory pre-conditioning |
| Measure | Description | Time Frame |
|---|---|---|
| Brain corticobulbar excitability | Change of Brain corticobulbar excitability by motor evoked potentials | Immediately after single conditioning the brain |
| Measure | Description | Time Frame |
|---|---|---|
| Tongue pressure measurement- | Change of tongue pressure measurement by Intra oral pressure assessment | Immediate after single conditioning the brain |
| Electrophysiological responses of swallowing - |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy young volunteers
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| Name | Affiliation | Role |
|---|---|---|
| Sun Im, MD PhD | The Catholic University of Korea | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Rehabilitation Medicine | Bucheon-si | Bucheonshi | South Korea | |||
| Department of Rehabilitation Medicine Bucheon St Mary's Hospital, Catholic University of Korea, College of Medicine |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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DNA of gene polymorphism from the Polymorphisms in brain-derived neurotrophic factor
Change of Electrophysiological responses of swallowing - With the use of a laryngeal transducer, will measure the mylohyoid amplitude
| Immediate after single conditioning the brain |
| Bucheon-si |
| Kyounggido |
| South Korea |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |