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The study investigates pain processing and pain reporting in patients with Alzheimers disease compared to healthy participants.
Employing a within-subject design, the study includes patients with Alzheimers disease and healthy participants that are exposed to thermal stimuli. During the test session the facial expressions of the participant are video recorded.
By repeating this on separate test days, the involvement of pain relief and pain increase is investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alzheimers diseased patients | Behavioral: Different thermal stimulation. Recording of facial expression during thermal stimulation. |
| |
| Healthy participants | Behavioral: Different thermal stimulation. Recording of facial expression during thermal stimulation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thermal stimulation | Behavioral | Thermal stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Numerical rating scale (NRS) | Acute pain assessed on numerical rating scale from 0 (no pain experience) to 10 (worst pain), examining pain intensity. The participant will provide a number on the scale which reflects their pain intensity. | Participants will be tested on three different days. The numerical rating scale will be applied after each thermal stimulus for each test session. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Assessment in persons with Impaired Cognition (PAIC) | Video recordings will be analyzed with the PAIC scale from 0 (not at all) to 3 (great degree). | Participants will be video recorded on each of the three test days during testing. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychology and Behavioural Sciences | Aarhus | Central Jutland | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37703397 | Derived | Matthiesen ST, Sieg M, Andersen SS, Amanzio M, Finnerup NB, Jensen TS, Gottrup H, Vase L. Placebo analgesia and nocebo hyperalgesia in patients with Alzheimer disease and healthy participants. Pain. 2024 Feb 1;165(2):440-449. doi: 10.1097/j.pain.0000000000003035. Epub 2023 Sep 8. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003704 | Dementia |
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| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |